9071156

2-[[(6-methylpyridin-2-yl)amino]methyl]phenol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2362
Screen concentration 126.0 μM
Source Chembridge (Fragment library)
PubChem CID 653133
SMILES CC1=NC(=CC=C1)NCC2=CC=CC=C2O
Standardized SMILES Cc1cccc(NCc2ccccc2O)n1
Molecular weight 214.2631
ALogP 2.65
H-bond donor count 2
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.01
% growth inhibition (Hom. pool) 9.37


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 653133
Download HIP data (tab-delimited text)  (excel)
Gene:ALR1(YOL130W)|FD-Score:-3.17|P-value:7.54E-4|Clearance:0||SGD DESC:Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions Gene:ARP7(YPR034W)|FD-Score:-3.37|P-value:3.72E-4|Clearance:0||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:ASA1(YPR085C)|FD-Score:-3.1|P-value:9.52E-4|Clearance:0||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 Gene:DPS1(YLL018C)|FD-Score:3.29|P-value:5.07E-4|Clearance:0.04||SGD DESC:Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation Gene:MPE1(YKL059C)|FD-Score:3.31|P-value:4.70E-4|Clearance:0.02||SGD DESC:Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif Gene:POL3(YDL102W)|FD-Score:3.91|P-value:4.61E-5|Clearance:0.28||SGD DESC:Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) Gene:POP4(YBR257W)|FD-Score:-4.1|P-value:2.08E-5|Clearance:0||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P Gene:PRP46(YPL151C)|FD-Score:3.6|P-value:1.62E-4|Clearance:0.23||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs Gene:PTR3(YFR029W)|FD-Score:3.37|P-value:3.82E-4|Clearance:0.01||SGD DESC:Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes Gene:RBA50(YDR527W)|FD-Score:3.17|P-value:7.66E-4|Clearance:0.11||SGD DESC:Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 Gene:RCL1(YOL010W)|FD-Score:-3.47|P-value:2.59E-4|Clearance:0||SGD DESC:Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected Gene:RRN11(YML043C)|FD-Score:4.01|P-value:3.08E-5|Clearance:0.28||SGD DESC:Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p Gene:RSC8(YFR037C)|FD-Score:-3.44|P-value:2.96E-4|Clearance:0||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SAD1(YFR005C)|FD-Score:4.21|P-value:1.26E-5|Clearance:0.28||SGD DESC:Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle Gene:TEN1(YLR010C)|FD-Score:3.35|P-value:4.00E-4|Clearance:0.05||SGD DESC:Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p Gene:TIM17(YJL143W)|FD-Score:3.25|P-value:5.76E-4|Clearance:0.08||SGD DESC:Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex Gene:TUB1(YML085C)|FD-Score:3.87|P-value:5.40E-5|Clearance:0.28||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication Gene:YOR146W(YOR146W_d)|FD-Score:3.95|P-value:3.97E-5|Clearance:0.28||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C Gene:ALR1(YOL130W)|FD-Score:-3.17|P-value:7.54E-4|Clearance:0||SGD DESC:Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions Gene:ARP7(YPR034W)|FD-Score:-3.37|P-value:3.72E-4|Clearance:0||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:ASA1(YPR085C)|FD-Score:-3.1|P-value:9.52E-4|Clearance:0||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 Gene:DPS1(YLL018C)|FD-Score:3.29|P-value:5.07E-4|Clearance:0.04||SGD DESC:Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation Gene:MPE1(YKL059C)|FD-Score:3.31|P-value:4.70E-4|Clearance:0.02||SGD DESC:Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif Gene:POL3(YDL102W)|FD-Score:3.91|P-value:4.61E-5|Clearance:0.28||SGD DESC:Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) Gene:POP4(YBR257W)|FD-Score:-4.1|P-value:2.08E-5|Clearance:0||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P Gene:PRP46(YPL151C)|FD-Score:3.6|P-value:1.62E-4|Clearance:0.23||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs Gene:PTR3(YFR029W)|FD-Score:3.37|P-value:3.82E-4|Clearance:0.01||SGD DESC:Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes Gene:RBA50(YDR527W)|FD-Score:3.17|P-value:7.66E-4|Clearance:0.11||SGD DESC:Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 Gene:RCL1(YOL010W)|FD-Score:-3.47|P-value:2.59E-4|Clearance:0||SGD DESC:Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected Gene:RRN11(YML043C)|FD-Score:4.01|P-value:3.08E-5|Clearance:0.28||SGD DESC:Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p Gene:RSC8(YFR037C)|FD-Score:-3.44|P-value:2.96E-4|Clearance:0||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SAD1(YFR005C)|FD-Score:4.21|P-value:1.26E-5|Clearance:0.28||SGD DESC:Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle Gene:TEN1(YLR010C)|FD-Score:3.35|P-value:4.00E-4|Clearance:0.05||SGD DESC:Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p Gene:TIM17(YJL143W)|FD-Score:3.25|P-value:5.76E-4|Clearance:0.08||SGD DESC:Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex Gene:TUB1(YML085C)|FD-Score:3.87|P-value:5.40E-5|Clearance:0.28||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication Gene:YOR146W(YOR146W_d)|FD-Score:3.95|P-value:3.97E-5|Clearance:0.28||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 653133
Download HOP data (tab-delimited text)  (excel)
Gene:AIM32(YML050W)|FD-Score:-4.3|P-value:8.58E-6||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ARG4(YHR018C)|FD-Score:4.17|P-value:1.50E-5||SGD DESC:Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway Gene:ATG27(YJL178C)|FD-Score:3.49|P-value:2.37E-4||SGD DESC:Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site Gene:COG5(YNL051W)|FD-Score:-4.19|P-value:1.39E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG7(YGL005C)|FD-Score:-3.39|P-value:3.55E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COQ10(YOL008W)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes Gene:DSF2(YBR007C_p)|FD-Score:3.72|P-value:1.01E-4||SGD DESC:Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:ERG3(YLR056W)|FD-Score:-3.1|P-value:9.76E-4||SGD DESC:C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase Gene:ERS1(YCR075C)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains Gene:FLC2(YAL053W)|FD-Score:6.27|P-value:1.86E-10||SGD DESC:Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication Gene:FPR4(YLR449W)|FD-Score:4.16|P-value:1.60E-5||SGD DESC:Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones Gene:FUM1(YPL262W)|FD-Score:3.17|P-value:7.61E-4||SGD DESC:Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria Gene:GLO1(YML004C)|FD-Score:4.08|P-value:2.30E-5||SGD DESC:Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress Gene:GTR2(YGR163W)|FD-Score:-3.54|P-value:1.99E-4||SGD DESC:Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD Gene:KNS1(YLL019C)|FD-Score:3.4|P-value:3.42E-4||SGD DESC:Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation Gene:LCL1(YPL056C_p)|FD-Score:-5.76|P-value:4.23E-9||SGD DESC:Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan Gene:LTV1(YKL143W)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature Gene:MCM16(YPR046W)|FD-Score:-3.56|P-value:1.83E-4||SGD DESC:Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 Gene:MRI1(YPR118W)|FD-Score:-3.09|P-value:9.85E-4||SGD DESC:5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway Gene:MRP13(YGR084C)|FD-Score:3.19|P-value:7.06E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSB1(YOR188W)|FD-Score:-3.86|P-value:5.65E-5||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:MTD1(YKR080W)|FD-Score:-3.82|P-value:6.61E-5||SGD DESC:NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline Gene:OSM1(YJR051W)|FD-Score:3.95|P-value:3.92E-5||SGD DESC:Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication Gene:PAH1(YMR165C)|FD-Score:-4.11|P-value:2.01E-5||SGD DESC:Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2 Gene:PAT1(YCR077C)|FD-Score:3.58|P-value:1.71E-4||SGD DESC:Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress Gene:PDC1(YLR044C)|FD-Score:-3.53|P-value:2.07E-4||SGD DESC:Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism Gene:PFK1(YGR240C)|FD-Score:3.32|P-value:4.52E-4||SGD DESC:Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:PHO81(YGR233C)|FD-Score:3.98|P-value:3.41E-5||SGD DESC:Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress Gene:PMT3(YOR321W)|FD-Score:7.67|P-value:8.53E-15||SGD DESC:Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication Gene:PUT2(YHR037W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism Gene:RPL27B(YDR471W)|FD-Score:4.02|P-value:2.97E-5||SGD DESC:Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication Gene:SFP1(YLR403W)|FD-Score:3.42|P-value:3.16E-4||SGD DESC:Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion Gene:SHM1(YBR263W)|FD-Score:5.69|P-value:6.52E-9||SGD DESC:Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine Gene:SUR1(YPL057C)|FD-Score:6.01|P-value:9.47E-10||SGD DESC:Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication Gene:TPN1(YGL186C)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:UTP30(YKR060W)|FD-Score:3.31|P-value:4.73E-4||SGD DESC:Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit Gene:VAM10(YOR068C)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering Gene:YBR200W-A(YBR200W-A_p)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR225W(YBR225W_p)|FD-Score:3.15|P-value:8.18E-4||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components Gene:YCP4(YCR004C)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YGL159W(YGL159W_p)|FD-Score:-3.84|P-value:6.19E-5||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YIL014C-A(YIL014C-A_p)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Putative protein of unknown function Gene:YIL092W(YIL092W_p)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus Gene:YIR043C(YIR043C)|FD-Score:-3.79|P-value:7.67E-5||SGD DESC:Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family Gene:YJL067W(YJL067W_d)|FD-Score:-3.41|P-value:3.21E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKL107W(YKL107W_p)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein Gene:YKR047W(YKR047W_d)|FD-Score:-3.56|P-value:1.87E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 Gene:YLR225C(YLR225C_p)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene Gene:YLR281C(YLR281C_p)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene Gene:YNL034W(YNL034W_p)|FD-Score:-3.31|P-value:4.69E-4||SGD DESC:Putative protein of unknown function; YNL034W is not an essential gene Gene:YNL035C(YNL035C_p)|FD-Score:3.21|P-value:6.74E-4||SGD DESC:Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YOR072W(YOR072W_d)|FD-Score:-4.55|P-value:2.68E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:YPK1(YKL126W)|FD-Score:-4.82|P-value:7.18E-7||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:YPR097W(YPR097W)|FD-Score:-6.78|P-value:5.85E-12||SGD DESC:Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPR153W(YPR153W)|FD-Score:3.96|P-value:3.75E-5||SGD DESC:Putative protein of unknown function Gene:AIM32(YML050W)|FD-Score:-4.3|P-value:8.58E-6||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ARG4(YHR018C)|FD-Score:4.17|P-value:1.50E-5||SGD DESC:Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway Gene:ATG27(YJL178C)|FD-Score:3.49|P-value:2.37E-4||SGD DESC:Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site Gene:COG5(YNL051W)|FD-Score:-4.19|P-value:1.39E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG7(YGL005C)|FD-Score:-3.39|P-value:3.55E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COQ10(YOL008W)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes Gene:DSF2(YBR007C_p)|FD-Score:3.72|P-value:1.01E-4||SGD DESC:Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:ERG3(YLR056W)|FD-Score:-3.1|P-value:9.76E-4||SGD DESC:C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase Gene:ERS1(YCR075C)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains Gene:FLC2(YAL053W)|FD-Score:6.27|P-value:1.86E-10||SGD DESC:Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication Gene:FPR4(YLR449W)|FD-Score:4.16|P-value:1.60E-5||SGD DESC:Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones Gene:FUM1(YPL262W)|FD-Score:3.17|P-value:7.61E-4||SGD DESC:Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria Gene:GLO1(YML004C)|FD-Score:4.08|P-value:2.30E-5||SGD DESC:Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress Gene:GTR2(YGR163W)|FD-Score:-3.54|P-value:1.99E-4||SGD DESC:Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD Gene:KNS1(YLL019C)|FD-Score:3.4|P-value:3.42E-4||SGD DESC:Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation Gene:LCL1(YPL056C_p)|FD-Score:-5.76|P-value:4.23E-9||SGD DESC:Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan Gene:LTV1(YKL143W)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature Gene:MCM16(YPR046W)|FD-Score:-3.56|P-value:1.83E-4||SGD DESC:Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 Gene:MRI1(YPR118W)|FD-Score:-3.09|P-value:9.85E-4||SGD DESC:5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway Gene:MRP13(YGR084C)|FD-Score:3.19|P-value:7.06E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSB1(YOR188W)|FD-Score:-3.86|P-value:5.65E-5||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:MTD1(YKR080W)|FD-Score:-3.82|P-value:6.61E-5||SGD DESC:NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline Gene:OSM1(YJR051W)|FD-Score:3.95|P-value:3.92E-5||SGD DESC:Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication Gene:PAH1(YMR165C)|FD-Score:-4.11|P-value:2.01E-5||SGD DESC:Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2 Gene:PAT1(YCR077C)|FD-Score:3.58|P-value:1.71E-4||SGD DESC:Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress Gene:PDC1(YLR044C)|FD-Score:-3.53|P-value:2.07E-4||SGD DESC:Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism Gene:PFK1(YGR240C)|FD-Score:3.32|P-value:4.52E-4||SGD DESC:Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:PHO81(YGR233C)|FD-Score:3.98|P-value:3.41E-5||SGD DESC:Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress Gene:PMT3(YOR321W)|FD-Score:7.67|P-value:8.53E-15||SGD DESC:Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication Gene:PUT2(YHR037W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism Gene:RPL27B(YDR471W)|FD-Score:4.02|P-value:2.97E-5||SGD DESC:Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication Gene:SFP1(YLR403W)|FD-Score:3.42|P-value:3.16E-4||SGD DESC:Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion Gene:SHM1(YBR263W)|FD-Score:5.69|P-value:6.52E-9||SGD DESC:Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine Gene:SUR1(YPL057C)|FD-Score:6.01|P-value:9.47E-10||SGD DESC:Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication Gene:TPN1(YGL186C)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:UTP30(YKR060W)|FD-Score:3.31|P-value:4.73E-4||SGD DESC:Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit Gene:VAM10(YOR068C)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering Gene:YBR200W-A(YBR200W-A_p)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR225W(YBR225W_p)|FD-Score:3.15|P-value:8.18E-4||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components Gene:YCP4(YCR004C)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YGL159W(YGL159W_p)|FD-Score:-3.84|P-value:6.19E-5||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YIL014C-A(YIL014C-A_p)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Putative protein of unknown function Gene:YIL092W(YIL092W_p)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus Gene:YIR043C(YIR043C)|FD-Score:-3.79|P-value:7.67E-5||SGD DESC:Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family Gene:YJL067W(YJL067W_d)|FD-Score:-3.41|P-value:3.21E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKL107W(YKL107W_p)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein Gene:YKR047W(YKR047W_d)|FD-Score:-3.56|P-value:1.87E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 Gene:YLR225C(YLR225C_p)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene Gene:YLR281C(YLR281C_p)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene Gene:YNL034W(YNL034W_p)|FD-Score:-3.31|P-value:4.69E-4||SGD DESC:Putative protein of unknown function; YNL034W is not an essential gene Gene:YNL035C(YNL035C_p)|FD-Score:3.21|P-value:6.74E-4||SGD DESC:Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YOR072W(YOR072W_d)|FD-Score:-4.55|P-value:2.68E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:YPK1(YKL126W)|FD-Score:-4.82|P-value:7.18E-7||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:YPR097W(YPR097W)|FD-Score:-6.78|P-value:5.85E-12||SGD DESC:Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPR153W(YPR153W)|FD-Score:3.96|P-value:3.75E-5||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YFR005C4.211.26E-50.28SAD1Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle
YML043C4.013.08E-50.28RRN11Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
YOR146W_d3.953.97E-50.28YOR146W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
YDL102W3.914.61E-50.28POL3Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
YML085C3.875.40E-50.28TUB1Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication
YPL151C3.601.62E-40.23PRP46Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
YFR029W3.373.82E-40.01PTR3Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YLR010C3.354.00E-40.05TEN1Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
YKL059C3.314.70E-40.02MPE1Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
YLL018C3.295.07E-40.04DPS1Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
YJL143W3.255.76E-40.08TIM17Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
YDR527W3.177.66E-40.11RBA50Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
YOR060C3.060.001110.02SLD7Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
YNL002C3.040.001180.23RLP7Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
YDR054C2.810.002440.01CDC34Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR321W7.678.53E-15PMT3Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication
YAL053W6.271.86E-10FLC2Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
YPL057C6.019.47E-10SUR1Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
YBR263W5.696.52E-9SHM1Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
YHR018C4.171.50E-5ARG4Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
YLR449W4.161.60E-5FPR4Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YML004C4.082.30E-5GLO1Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress
YDR471W4.022.97E-5RPL27BRibosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication
YGR233C3.983.41E-5PHO81Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress
YPR153W3.963.75E-5YPR153WPutative protein of unknown function
YJR051W3.953.92E-5OSM1Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication
YBR007C_p3.721.01E-4DSF2_pDeletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress
YGL186C3.691.11E-4TPN1Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p
YCR004C3.601.60E-4YCP4Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR077C3.581.71E-4PAT1Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress

GO enrichment analysis for SGTC_2362
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0952.35E-13SGTC_23639053361 176.0 μMChembridge (Fragment library)64697970.105263Golgi
0.0881.61E-11SGTC_1466k213-0079 57.5 μMChemDiv (Drug-like library)36579810.134328
0.0708.94E-8SGTC_30969117468 49.5 μMChembridge (Drug-like library)413163110.0793651
0.0664.83E-7SGTC_1900st060200 72.8 μMTimTec (Natural product derivative library)6889450.103448
0.0603.82E-6SGTC_9373122-0005 46.7 μMChemDiv (Drug-like library)7595350.137931
0.0571.29E-5SGTC_31199125183 49.5 μMChembridge (Drug-like library)226953340.140351
0.0561.93E-5SGTC_1764st044502 93.5 μMTimTec (Natural product derivative library)84070.12
0.0552.29E-5SGTC_13893405-0187 19.0 μMChemDiv (Drug-like library)7998900.1
0.0543.46E-5SGTC_23669070441 60.6 μMChembridge (Fragment library)68372350.163265
0.0543.71E-5SGTC_1886st057356 49.9 μMTimTec (Natural product derivative library)242077470.03896160S ribosome export
0.0519.43E-5SGTC_30049076122 71.4 μMChembridge (Drug-like library)447825510.123077
0.0491.75E-4SGTC_11911487-1166 10.6 μMChemDiv (Drug-like library)39557710.0819672azole & statin
0.0464.05E-4SGTC_1889st059080 5.2 μMTimTec (Natural product derivative library)1769250.166667
0.0464.36E-4SGTC_1606st000094 49.2 μMTimTec (Natural product derivative library)12422100.095890460S ribosome export
0.0464.49E-4SGTC_20044023728 41.9 μMChembridge (Fragment library)3600840.0588235

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_23679070478135.38 μM0.560976572802Chembridge (Fragment library)214.263062.85423cell wall
SGTC_23217390090138.78 μM0.477273649046Chembridge (Fragment library)214.263062.85423
SGTC_23459052315157.45 μM0.3695656469265Chembridge (Fragment library)193.24561.48922
SGTC_8890919-152482.7 μM0.3584913905452ChemDiv (Drug-like library)274.271962.85825
SGTC_20295175081200 μM0.3181821380876Chembridge (Fragment library)174.19922.12223
SGTC_3181488-062967.2 μM0.2962963662576ChemDiv (Drug-like library)263.272462.25815copper-dependent oxidative stress
SGTC_3354915161271.43 μM0.28813627261949Chembridge (Drug-like library)334.433183.78715
SGTC_23729071633200 μM0.26666721321366Chembridge (Fragment library)199.248422.9822
SGTC_3191348-159645.5 μM0.2653065380505ChemDiv (Drug-like library)213.235241.1624RSC & ERG11
SGTC_23549060492162 μM0.266471895Chembridge (Fragment library)201.26761.27823