Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YMR079W | 12.10 | 3.87E-34 | 3.79 | SEC14 | Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs |
YER133W | 8.34 | 3.73E-17 | 2.01 | GLC7 | Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest |
YDR526C_d | 6.33 | 1.21E-10 | 0.77 | YDR526C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YBR091C | 5.57 | 1.31E-8 | 0.08 | TIM12 | Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins |
YNL007C | 5.49 | 2.06E-8 | 0.64 | SIS1 | Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; has similarity to bacterial DnaJ proteins; protein abundance increases in response to DNA replication stress |
YGL074C_d | 4.85 | 6.19E-7 | 0.04 | YGL074C_d | Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor |
YBL004W | 4.81 | 7.44E-7 | 0.25 | UTP20 | Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA |
YPL175W | 4.56 | 2.57E-6 | 0.23 | SPT14 | UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins |
YOR159C | 4.33 | 7.56E-6 | 0.17 | SME1 | Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E |
YFR029W | 4.16 | 1.59E-5 | 0.10 | PTR3 | Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes |
YOL146W | 4.05 | 2.51E-5 | 0.44 | PSF3 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YDL164C | 3.61 | 1.52E-4 | 0.01 | CDC9 | DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination |
YML043C | 3.61 | 1.55E-4 | 0.02 | RRN11 | Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p |
YCR093W | 3.59 | 1.66E-4 | 0.07 | CDC39 | Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor |
YMR013C | 3.52 | 2.16E-4 | 0.08 | SEC59 | Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation |