Deletion Strain | FD score | P-value | Gene | Gene Description |
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YHR039C | 12.60 | 1.16E-36 | MSC7 | Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids |
YKL132C | 8.05 | 4.16E-16 | RMA1 | Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YKL143W | 7.80 | 3.00E-15 | LTV1 | Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature |
YPR046W | 7.68 | 8.03E-15 | MCM16 | Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 |
YEL029C | 6.64 | 1.53E-11 | BUD16 | Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) |
YAR003W | 6.62 | 1.74E-11 | SWD1 | Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 |
YPL213W | 6.62 | 1.81E-11 | LEA1 | Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein |
YNL170W_d | 6.28 | 1.68E-10 | YNL170W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YJL095W | 6.23 | 2.34E-10 | BCK1 | Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p |
YER026C | 5.99 | 1.08E-9 | CHO1 | Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline |
YER004W | 5.35 | 4.33E-8 | FMP52 | Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation |
YHR194W | 5.19 | 1.04E-7 | MDM31 | Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 |
YPL055C | 5.15 | 1.29E-7 | LGE1 | Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division |
YGL013C | 5.08 | 1.92E-7 | PDR1 | Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication |
YER011W | 5.00 | 2.85E-7 | TIR1 | Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking |