Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPL169C | 5.87 | 2.13E-9 | 1.32 | MEX67 | Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP |
YPR182W | 4.55 | 2.62E-6 | 0.64 | SMX3 | Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F |
YOL144W | 3.91 | 4.53E-5 | 0.12 | NOP8 | Nucleolar protein required for 60S ribosomal subunit biogenesis |
YGL074C_d | 3.80 | 7.30E-5 | 0.57 | YGL074C_d | Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor |
YNL062C | 3.23 | 6.26E-4 | 0.08 | GCD10 | Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression |
YDL087C | 3.15 | 8.19E-4 | 0.08 | LUC7 | Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA |
YJL143W | 3.06 | 0.00109 | 0.11 | TIM17 | Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex |
YIL048W | 2.96 | 0.00155 | 0.01 | NEO1 | Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus |
YNL161W | 2.95 | 0.00160 | 0.07 | CBK1 | Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress |
YJL173C | 2.88 | 0.00197 | 0.12 | RFA3 | Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress |
YIL091C | 2.76 | 0.00285 | 0.03 | UTP25 | Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis |
YDR187C_d | 2.73 | 0.00315 | 0.02 | YDR187C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W |
YMR079W | 2.71 | 0.00333 | 0.03 | SEC14 | Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs |
YDR339C | 2.68 | 0.00366 | 0.01 | FCF1 | Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p |
YNL088W | 2.67 | 0.00374 | 0.00 | TOP2 | Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation |