| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YMR267W | 6.28 | 1.70E-10 | PPA2 | Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate |
| YBL106C | 5.91 | 1.74E-9 | SRO77 | Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication |
| YPL049C | 5.21 | 9.19E-8 | DIG1 | MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p |
| YFL027C | 4.76 | 9.49E-7 | GYP8 | GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport |
| YOR355W | 4.75 | 1.02E-6 | GDS1 | Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| YJL004C | 4.65 | 1.68E-6 | SYS1 | Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation |
| YIL013C | 4.37 | 6.08E-6 | PDR11 | ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth |
| YJR099W | 4.24 | 1.14E-5 | YUH1 | Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p |
| YOL031C | 4.15 | 1.63E-5 | SIL1 | Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein |
| YOR248W_d | 4.11 | 2.01E-5 | YOR248W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YNL025C | 4.00 | 3.12E-5 | SSN8 | Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance |
| YOR161C-C_p | 3.86 | 5.78E-5 | YOR161C-C_p | Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| YER028C | 3.85 | 5.79E-5 | MIG3 | Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication |
| YOL090W | 3.83 | 6.44E-5 | MSH2 | Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP |
| YGL109W_d | 3.81 | 6.88E-5 | YGL109W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C |
