| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YMR267W | 5.75 | 4.59E-9 | PPA2 | Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate |
| YOR327C | 5.16 | 1.25E-7 | SNC2 | Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication |
| YPR036W | 4.98 | 3.25E-7 | VMA13 | Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase |
| YAL011W | 4.84 | 6.46E-7 | SWC3 | Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae |
| YNL336W | 4.67 | 1.48E-6 | COS1 | Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins |
| YNR064C | 4.57 | 2.43E-6 | YNR064C | Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides |
| YPL258C | 4.47 | 3.89E-6 | THI21 | Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p |
| YDR293C | 4.45 | 4.22E-6 | SSD1 | Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function |
| YBL072C | 4.34 | 7.04E-6 | RPS8A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication |
| YLR357W | 4.32 | 7.87E-6 | RSC2 | Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance |
| YER116C | 4.24 | 1.11E-5 | SLX8 | Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress |
| YCR106W | 4.21 | 1.27E-5 | RDS1 | Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide |
| YNR034W | 4.18 | 1.45E-5 | SOL1 | Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
| YKR084C | 4.13 | 1.78E-5 | HBS1 | GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay |
| YGL005C | 4.10 | 2.07E-5 | COG7 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
