Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YNL287W | 4.71 | 1.25E-6 | 0.43 | SEC21 | Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo |
YOL097C | 4.57 | 2.48E-6 | 0.43 | WRS1 | Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA |
YIL144W | 4.22 | 1.23E-5 | 0.43 | TID3 | Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering |
YHR020W | 4.16 | 1.61E-5 | 0.43 | YHR020W | Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments |
YHR172W | 4.12 | 1.92E-5 | 0.43 | SPC97 | Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque |
YNL182C | 3.69 | 1.13E-4 | 0.02 | IPI3 | Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene |
YMR211W | 3.67 | 1.23E-4 | 0.18 | DML1 | Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family |
YFL029C | 3.48 | 2.47E-4 | 0.19 | CAK1 | Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases |
YDR145W | 3.30 | 4.90E-4 | 0.02 | TAF12 | Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A |
YGR115C_d | 3.27 | 5.32E-4 | 0.00 | YGR115C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C |
YDR429C | 3.27 | 5.39E-4 | 0.04 | TIF35 | eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation |
YDR487C | 3.23 | 6.20E-4 | 0.18 | RIB3 | 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration |
YCL041C_d | 3.05 | 0.00113 | 0.00 | YCL041C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W |
YFL037W | 3.05 | 0.00114 | 0.07 | TUB2 | Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria |
YPL075W | 2.98 | 0.00144 | 0.10 | GCR1 | Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p |