Deletion Strain | FD score | P-value | Gene | Gene Description |
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YAL048C | 7.37 | 8.34E-14 | GEM1 | Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases |
YKL037W | 6.49 | 4.16E-11 | AIM26 | Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT |
YPL049C | 6.29 | 1.58E-10 | DIG1 | MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p |
YOR279C | 6.25 | 2.07E-10 | RFM1 | DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance |
YJL147C_p | 5.29 | 6.26E-8 | YJL147C_p | Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene |
YGR271W | 5.16 | 1.25E-7 | SLH1 | Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses |
YGR282C | 5.04 | 2.32E-7 | BGL2 | Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance |
YFR032C-A | 5.02 | 2.63E-7 | RPL29 | Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog |
YKR089C | 4.58 | 2.31E-6 | TGL4 | Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p |
YLR284C | 4.53 | 2.94E-6 | ECI1 | Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced |
YGR269W_d | 4.23 | 1.19E-5 | YGR269W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C |
YIR028W | 4.18 | 1.45E-5 | DAL4 | Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation |
YJR044C | 4.11 | 1.99E-5 | VPS55 | Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) |
YIR038C | 4.04 | 2.72E-5 | GTT1 | ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p |
YGR125W_p | 3.90 | 4.76E-5 | YGR125W_p | Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole |