9075165

N-(1,2-benzoxazol-3-yl)cyclopropanecarboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2386
Screen concentration 157.4 μM
Source Chembridge (Fragment library)
PubChem CID 16452277
SMILES C1CC1C(=O)NC2=NOC3=CC=CC=C32
Standardized SMILES O=C(Nc1noc2ccccc12)C3CC3
Molecular weight 202.2093
ALogP 1.9
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.1
% growth inhibition (Hom. pool) 2.36


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 16452277
Download HIP data (tab-delimited text)  (excel)
Gene:BFR2(YDR299W)|FD-Score:3.57|P-value:1.77E-4|Clearance:0.2||SGD DESC:Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock Gene:DIS3(YOL021C)|FD-Score:3.38|P-value:3.68E-4|Clearance:0.2||SGD DESC:Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress Gene:KRE29(YER038C)|FD-Score:-3.29|P-value:4.95E-4|Clearance:0||SGD DESC:Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance Gene:MOB1(YIL106W)|FD-Score:-3.2|P-value:6.84E-4|Clearance:0||SGD DESC:Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:NOP1(YDL014W)|FD-Score:4.09|P-value:2.17E-5|Clearance:0.33||SGD DESC:Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin Gene:OLE1(YGL055W)|FD-Score:3.14|P-value:8.55E-4|Clearance:0.19||SGD DESC:Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria Gene:POL30(YBR088C)|FD-Score:3.18|P-value:7.39E-4|Clearance:0.04||SGD DESC:Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair Gene:SEC9(YGR009C)|FD-Score:3.9|P-value:4.73E-5|Clearance:0.33||SGD DESC:t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog Gene:BFR2(YDR299W)|FD-Score:3.57|P-value:1.77E-4|Clearance:0.2||SGD DESC:Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock Gene:DIS3(YOL021C)|FD-Score:3.38|P-value:3.68E-4|Clearance:0.2||SGD DESC:Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress Gene:KRE29(YER038C)|FD-Score:-3.29|P-value:4.95E-4|Clearance:0||SGD DESC:Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance Gene:MOB1(YIL106W)|FD-Score:-3.2|P-value:6.84E-4|Clearance:0||SGD DESC:Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:NOP1(YDL014W)|FD-Score:4.09|P-value:2.17E-5|Clearance:0.33||SGD DESC:Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin Gene:OLE1(YGL055W)|FD-Score:3.14|P-value:8.55E-4|Clearance:0.19||SGD DESC:Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria Gene:POL30(YBR088C)|FD-Score:3.18|P-value:7.39E-4|Clearance:0.04||SGD DESC:Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair Gene:SEC9(YGR009C)|FD-Score:3.9|P-value:4.73E-5|Clearance:0.33||SGD DESC:t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 16452277
Download HOP data (tab-delimited text)  (excel)
Gene:ADE12(YNL220W)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence Gene:AFR1(YDR085C)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication Gene:AHA1(YDR214W)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:ALK1(YGL021W)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins Gene:ATE1(YGL017W)|FD-Score:4.85|P-value:6.29E-7||SGD DESC:Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway Gene:BAS1(YKR099W)|FD-Score:4.37|P-value:6.13E-6||SGD DESC:Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Gene:BNA3(YJL060W)|FD-Score:3.89|P-value:5.09E-5||SGD DESC:Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate Gene:CUR1(YPR158W)|FD-Score:3.41|P-value:3.30E-4||SGD DESC:Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication Gene:DPP1(YDR284C)|FD-Score:5.85|P-value:2.52E-9||SGD DESC:Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism Gene:DTD1(YDL219W)|FD-Score:-3.53|P-value:2.11E-4||SGD DESC:D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes Gene:GIS3(YLR094C)|FD-Score:-3.14|P-value:8.32E-4||SGD DESC:Protein of unknown function Gene:GOR1(YNL274C)|FD-Score:3.17|P-value:7.74E-4||SGD DESC:Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:HUL5(YGL141W)|FD-Score:-3.19|P-value:7.13E-4||SGD DESC:Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD Gene:MUS81(YDR386W)|FD-Score:4.46|P-value:4.08E-6||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:NFU1(YKL040C)|FD-Score:-3.63|P-value:1.40E-4||SGD DESC:Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria Gene:NOT3(YIL038C)|FD-Score:-3.88|P-value:5.14E-5||SGD DESC:Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation Gene:NQM1(YGR043C)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift Gene:RGS2(YOR107W)|FD-Score:3.19|P-value:7.08E-4||SGD DESC:Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p Gene:RTC4(YNL254C)|FD-Score:-3.27|P-value:5.29E-4||SGD DESC:Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:RXT3(YDL076C)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress Gene:SFB2(YNL049C)|FD-Score:-3.42|P-value:3.17E-4||SGD DESC:Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p Gene:SIP5(YMR140W)|FD-Score:-3.3|P-value:4.90E-4||SGD DESC:Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress Gene:SKN1(YGR143W)|FD-Score:-4.36|P-value:6.39E-6||SGD DESC:Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p Gene:SWD3(YBR175W)|FD-Score:3.13|P-value:8.88E-4||SGD DESC:Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 Gene:TED1(YIL039W)|FD-Score:-3.33|P-value:4.41E-4||SGD DESC:Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:TOK1(YJL093C)|FD-Score:-3.58|P-value:1.75E-4||SGD DESC:Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin Gene:TSC3(YBR058C-A)|FD-Score:3.78|P-value:7.71E-5||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:VTC1(YER072W)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress Gene:YBL029C-A(YBL029C-A_p)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica Gene:YDL073W(YDL073W_p)|FD-Score:4.03|P-value:2.79E-5||SGD DESC:Putative protein of unknown function; YDL073W is not an essential gene Gene:YER188W(YER188W_d)|FD-Score:3.93|P-value:4.21E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Gene:YGL082W(YGL082W_p)|FD-Score:3.83|P-value:6.36E-5||SGD DESC:Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene Gene:YGR021W(YGR021W_p)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YLR063W(YLR063W_p)|FD-Score:-3.32|P-value:4.42E-4||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene Gene:YLR407W(YLR407W_p)|FD-Score:5.36|P-value:4.21E-8||SGD DESC:Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus Gene:YOR277C(YOR277C_d)|FD-Score:3.83|P-value:6.33E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Gene:ADE12(YNL220W)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence Gene:AFR1(YDR085C)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication Gene:AHA1(YDR214W)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:ALK1(YGL021W)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins Gene:ATE1(YGL017W)|FD-Score:4.85|P-value:6.29E-7||SGD DESC:Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway Gene:BAS1(YKR099W)|FD-Score:4.37|P-value:6.13E-6||SGD DESC:Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Gene:BNA3(YJL060W)|FD-Score:3.89|P-value:5.09E-5||SGD DESC:Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate Gene:CUR1(YPR158W)|FD-Score:3.41|P-value:3.30E-4||SGD DESC:Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication Gene:DPP1(YDR284C)|FD-Score:5.85|P-value:2.52E-9||SGD DESC:Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism Gene:DTD1(YDL219W)|FD-Score:-3.53|P-value:2.11E-4||SGD DESC:D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes Gene:GIS3(YLR094C)|FD-Score:-3.14|P-value:8.32E-4||SGD DESC:Protein of unknown function Gene:GOR1(YNL274C)|FD-Score:3.17|P-value:7.74E-4||SGD DESC:Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:HUL5(YGL141W)|FD-Score:-3.19|P-value:7.13E-4||SGD DESC:Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD Gene:MUS81(YDR386W)|FD-Score:4.46|P-value:4.08E-6||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:NFU1(YKL040C)|FD-Score:-3.63|P-value:1.40E-4||SGD DESC:Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria Gene:NOT3(YIL038C)|FD-Score:-3.88|P-value:5.14E-5||SGD DESC:Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation Gene:NQM1(YGR043C)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift Gene:RGS2(YOR107W)|FD-Score:3.19|P-value:7.08E-4||SGD DESC:Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p Gene:RTC4(YNL254C)|FD-Score:-3.27|P-value:5.29E-4||SGD DESC:Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:RXT3(YDL076C)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress Gene:SFB2(YNL049C)|FD-Score:-3.42|P-value:3.17E-4||SGD DESC:Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p Gene:SIP5(YMR140W)|FD-Score:-3.3|P-value:4.90E-4||SGD DESC:Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress Gene:SKN1(YGR143W)|FD-Score:-4.36|P-value:6.39E-6||SGD DESC:Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p Gene:SWD3(YBR175W)|FD-Score:3.13|P-value:8.88E-4||SGD DESC:Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 Gene:TED1(YIL039W)|FD-Score:-3.33|P-value:4.41E-4||SGD DESC:Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:TOK1(YJL093C)|FD-Score:-3.58|P-value:1.75E-4||SGD DESC:Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin Gene:TSC3(YBR058C-A)|FD-Score:3.78|P-value:7.71E-5||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:VTC1(YER072W)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress Gene:YBL029C-A(YBL029C-A_p)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica Gene:YDL073W(YDL073W_p)|FD-Score:4.03|P-value:2.79E-5||SGD DESC:Putative protein of unknown function; YDL073W is not an essential gene Gene:YER188W(YER188W_d)|FD-Score:3.93|P-value:4.21E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Gene:YGL082W(YGL082W_p)|FD-Score:3.83|P-value:6.36E-5||SGD DESC:Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene Gene:YGR021W(YGR021W_p)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YLR063W(YLR063W_p)|FD-Score:-3.32|P-value:4.42E-4||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene Gene:YLR407W(YLR407W_p)|FD-Score:5.36|P-value:4.21E-8||SGD DESC:Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus Gene:YOR277C(YOR277C_d)|FD-Score:3.83|P-value:6.33E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDL014W4.092.17E-50.33NOP1Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YGR009C3.904.73E-50.33SEC9t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
YDR299W3.571.77E-40.20BFR2Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
YOL021C3.383.68E-40.20DIS3Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
YBR088C3.187.39E-40.04POL30Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
YGL055W3.148.55E-40.19OLE1Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YDL098C2.950.001610.03SNU23Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome
YGL061C2.920.001780.08DUO1Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YPR035W2.830.002310.02GLN1Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
YDL103C2.810.002450.04QRI1UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress
YPR025C2.780.002740.03CCL1Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
YGL018C2.750.002980.02JAC1Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
YDR311W2.730.003150.03TFB1Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators
YKL058W2.700.003420.08TOA2TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
YGL201C2.620.004350.01MCM6Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR284C5.852.52E-9DPP1Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
YLR407W_p5.364.21E-8YLR407W_pPutative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
YGL017W4.856.29E-7ATE1Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
YDR386W4.464.08E-6MUS81Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
YKR099W4.376.13E-6BAS1Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YNL220W4.221.22E-5ADE12Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
YDL073W_p4.032.79E-5YDL073W_pPutative protein of unknown function; YDL073W is not an essential gene
YER188W_d3.934.21E-5YER188W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p
YJL060W3.895.09E-5BNA3Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
YOR277C_d3.836.33E-5YOR277C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YGL082W_p3.836.36E-5YGL082W_pPutative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
YBR058C-A3.787.71E-5TSC3Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
YGL021W3.621.45E-4ALK1Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins
YER072W3.621.48E-4VTC1Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
YDL076C3.591.65E-4RXT3Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_2386
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1632.47E-36SGTC_23839036125 200.0 μMChembridge (Fragment library)795800.0793651
0.1373.83E-26SGTC_23729071633 200.0 μMChembridge (Fragment library)213213660.113208
0.1343.41E-25SGTC_320928-0142 34.1 μMChemDiv (Drug-like library)22442420.0909091TSC3-RPN4
0.1339.51E-25SGTC_21105483698 200.0 μMChembridge (Fragment library)28487650.0847458TSC3-RPN4
0.1232.38E-21SGTC_32369132701 49.5 μMChembridge (Drug-like library)242825240.173913TSC3-RPN4
0.1232.79E-21SGTC_22176934799 96.1 μMChembridge (Fragment library)6756060.101695TSC3-RPN4
0.1201.72E-20SGTC_7901575-0012 79.1 μMChemDiv (Drug-like library)3787410.0666667TSC3-RPN4
0.1202.40E-20SGTC_18584-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 μMTimTec (Natural product derivative library)7563770.0724638TSC3-RPN4
0.1202.96E-20SGTC_520329-0193 875.0 nMChemDiv (Drug-like library)37392920.112903TSC3-RPN4
0.1151.02E-18SGTC_1604st002052 72.4 μMTimTec (Natural product derivative library)62548340.178571TSC3-RPN4
0.1124.98E-18SGTC_1603st002045 67.8 μMTimTec (Natural product derivative library)58879850.1TSC3-RPN4
0.1101.92E-17SGTC_12991079-1439 3.7 μMChemDiv (Drug-like library)3231610.0909091TSC3-RPN4
0.1062.27E-16SGTC_2537larixol 68.9 μMMicrosource (Natural product library)67087590.0410959
0.1017.59E-15SGTC_8850865-0106 16.8 μMChemDiv (Drug-like library)27933800.107143TSC3-RPN4
0.0978.31E-14SGTC_9851493-0307 8.7 μMChemDiv (Drug-like library)32782740.0666667TSC3-RPN4

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_22027226349200 μM0.346939844334Chembridge (Fragment library)217.306763.38811
SGTC_10603448-735082 μM0.3125570178ChemDiv (Drug-like library)237.253342.91812Golgi
SGTC_3129912725749.47 μM0.307692837894Chembridge (Drug-like library)249.371763.61812
SGTC_2279794842332.93 μM0.2982461247112Chembridge (Fragment library)260.311583.18314
SGTC_22186965428192.98 μM0.27451675684Chembridge (Fragment library)238.306061.12823TSC3-RPN4
SGTC_2913796655636.57 μM0.2615382976516Chembridge (Drug-like library)372.43813.3982560S ribosome export
SGTC_9473447-0010211 μM0.259259748350ChemDiv (Drug-like library)238.24142.59813
SGTC_3265913726649.47 μM0.25862117224265Chembridge (Drug-like library)357.274783.71112
SGTC_11493909-796123.3 μM0.254902735261ChemDiv (Drug-like library)241.331464.0513
SGTC_22117117706200 μM0.25822771Chembridge (Fragment library)177.199841.28522