N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide

N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2392
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 803109
SMILES C1=CC(=CC(=C1)Cl)NC(=O)C2=CNC(=O)C=C2
Standardized SMILES Oc1ccc(cn1)C(=O)Nc2cccc(Cl)c2
Molecular weight 248.6651
ALogP 1.09
H-bond donor count 2
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 10.37
% growth inhibition (Hom. pool) 5.47


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 803109
Download HIP data (tab-delimited text)  (excel)
Gene:BBP1(YPL255W)|FD-Score:-3.35|P-value:3.97E-4|Clearance:0||SGD DESC:Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Gene:BRR6(YGL247W)|FD-Score:7.17|P-value:3.77E-13|Clearance:1.88||SGD DESC:Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism Gene:CAK1(YFL029C)|FD-Score:3.81|P-value:7.02E-5|Clearance:0.16||SGD DESC:Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases Gene:CCL1(YPR025C)|FD-Score:-3.92|P-value:4.50E-5|Clearance:0||SGD DESC:Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters Gene:CDC28(YBR160W)|FD-Score:3.9|P-value:4.84E-5|Clearance:0.02||SGD DESC:Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress Gene:DAD2(YKR083C)|FD-Score:3.25|P-value:5.81E-4|Clearance:0.1||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Gene:GLC7(YER133W)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.04||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:HCA4(YJL033W)|FD-Score:3.38|P-value:3.56E-4|Clearance:0.05||SGD DESC:DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis Gene:KRE29(YER038C)|FD-Score:5.78|P-value:3.81E-9|Clearance:1.88||SGD DESC:Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance Gene:MAK16(YAL025C)|FD-Score:3.34|P-value:4.24E-4|Clearance:0.03||SGD DESC:Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus Gene:MMF1(YIL051C)|FD-Score:3.3|P-value:4.78E-4|Clearance:0.06||SGD DESC:Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes Gene:MOB2(YFL034C-B)|FD-Score:-3.78|P-value:7.76E-5|Clearance:0||SGD DESC:Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p Gene:RNA1(YMR235C)|FD-Score:3.65|P-value:1.31E-4|Clearance:0.02||SGD DESC:GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport Gene:RRB1(YMR131C)|FD-Score:-3.69|P-value:1.10E-4|Clearance:0||SGD DESC:Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p Gene:SEC21(YNL287W)|FD-Score:3.53|P-value:2.11E-4|Clearance:0.05||SGD DESC:Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo Gene:SMC2(YFR031C)|FD-Score:3.58|P-value:1.69E-4|Clearance:0.06||SGD DESC:Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus Gene:SPT5(YML010W)|FD-Score:3.88|P-value:5.25E-5|Clearance:0.07||SGD DESC:Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair Gene:SRP101(YDR292C)|FD-Score:3.15|P-value:8.09E-4|Clearance:0.28||SGD DESC:Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p Gene:SRP54(YPR088C)|FD-Score:-3.92|P-value:4.46E-5|Clearance:0||SGD DESC:Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain Gene:YLR198C(YLR198C_d)|FD-Score:-3.11|P-value:9.24E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W Gene:YOR282W(YOR282W_d)|FD-Score:3.48|P-value:2.54E-4|Clearance:0.09||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C Gene:BBP1(YPL255W)|FD-Score:-3.35|P-value:3.97E-4|Clearance:0||SGD DESC:Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Gene:BRR6(YGL247W)|FD-Score:7.17|P-value:3.77E-13|Clearance:1.88||SGD DESC:Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism Gene:CAK1(YFL029C)|FD-Score:3.81|P-value:7.02E-5|Clearance:0.16||SGD DESC:Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases Gene:CCL1(YPR025C)|FD-Score:-3.92|P-value:4.50E-5|Clearance:0||SGD DESC:Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters Gene:CDC28(YBR160W)|FD-Score:3.9|P-value:4.84E-5|Clearance:0.02||SGD DESC:Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress Gene:DAD2(YKR083C)|FD-Score:3.25|P-value:5.81E-4|Clearance:0.1||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Gene:GLC7(YER133W)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.04||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:HCA4(YJL033W)|FD-Score:3.38|P-value:3.56E-4|Clearance:0.05||SGD DESC:DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis Gene:KRE29(YER038C)|FD-Score:5.78|P-value:3.81E-9|Clearance:1.88||SGD DESC:Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance Gene:MAK16(YAL025C)|FD-Score:3.34|P-value:4.24E-4|Clearance:0.03||SGD DESC:Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus Gene:MMF1(YIL051C)|FD-Score:3.3|P-value:4.78E-4|Clearance:0.06||SGD DESC:Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes Gene:MOB2(YFL034C-B)|FD-Score:-3.78|P-value:7.76E-5|Clearance:0||SGD DESC:Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p Gene:RNA1(YMR235C)|FD-Score:3.65|P-value:1.31E-4|Clearance:0.02||SGD DESC:GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport Gene:RRB1(YMR131C)|FD-Score:-3.69|P-value:1.10E-4|Clearance:0||SGD DESC:Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p Gene:SEC21(YNL287W)|FD-Score:3.53|P-value:2.11E-4|Clearance:0.05||SGD DESC:Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo Gene:SMC2(YFR031C)|FD-Score:3.58|P-value:1.69E-4|Clearance:0.06||SGD DESC:Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus Gene:SPT5(YML010W)|FD-Score:3.88|P-value:5.25E-5|Clearance:0.07||SGD DESC:Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair Gene:SRP101(YDR292C)|FD-Score:3.15|P-value:8.09E-4|Clearance:0.28||SGD DESC:Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p Gene:SRP54(YPR088C)|FD-Score:-3.92|P-value:4.46E-5|Clearance:0||SGD DESC:Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain Gene:YLR198C(YLR198C_d)|FD-Score:-3.11|P-value:9.24E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W Gene:YOR282W(YOR282W_d)|FD-Score:3.48|P-value:2.54E-4|Clearance:0.09||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 803109
Download HOP data (tab-delimited text)  (excel)
Gene:AFG1(YEL052W)|FD-Score:-3.54|P-value:1.97E-4||SGD DESC:Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain Gene:AFI1(YOR129C)|FD-Score:3.16|P-value:7.78E-4||SGD DESC:Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p Gene:ASF1(YJL115W)|FD-Score:-6.23|P-value:2.27E-10||SGD DESC:Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition Gene:ATG8(YBL078C)|FD-Score:4.36|P-value:6.46E-6||SGD DESC:Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis Gene:BGL2(YGR282C)|FD-Score:4.91|P-value:4.46E-7||SGD DESC:Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance Gene:BLS1(YLR408C_p)|FD-Score:3.8|P-value:7.32E-5||SGD DESC:Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene Gene:BTN2(YGR142W)|FD-Score:3.15|P-value:8.07E-4||SGD DESC:v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication Gene:CDC73(YLR418C)|FD-Score:3.25|P-value:5.86E-4||SGD DESC:Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress Gene:FAU1(YER183C)|FD-Score:3.12|P-value:9.13E-4||SGD DESC:5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis Gene:GRE3(YHR104W)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress Gene:HAL5(YJL165C)|FD-Score:-3.16|P-value:7.99E-4||SGD DESC:Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication Gene:IRC14(YOR135C_d)|FD-Score:4.73|P-value:1.15E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci Gene:IRC25(YLR021W)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:KIN82(YCR091W)|FD-Score:3.19|P-value:7.15E-4||SGD DESC:Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p Gene:MAC1(YMR021C)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MAD2(YJL030W)|FD-Score:4.11|P-value:1.97E-5||SGD DESC:Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I Gene:MDS3(YGL197W)|FD-Score:3.78|P-value:7.89E-5||SGD DESC:Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain Gene:MEP1(YGR121C)|FD-Score:3.91|P-value:4.55E-5||SGD DESC:Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation Gene:MUP3(YHL036W)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:Low affinity methionine permease, similar to Mup1p Gene:PBP1(YGR178C)|FD-Score:3.27|P-value:5.39E-4||SGD DESC:Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:RCR1(YBR005W)|FD-Score:-3.57|P-value:1.81E-4||SGD DESC:Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication Gene:RPS16A(YMR143W)|FD-Score:-3.14|P-value:8.44E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication Gene:RPS22A(YJL190C)|FD-Score:5.27|P-value:6.77E-8||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication Gene:RPS4B(YHR203C)|FD-Score:-3.71|P-value:1.04E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication Gene:RRM3(YHR031C)|FD-Score:5.33|P-value:4.93E-8||SGD DESC:DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Gene:RRT6(YGL146C_p)|FD-Score:-3.24|P-value:6.02E-4||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins Gene:SDC1(YDR469W)|FD-Score:3.41|P-value:3.22E-4||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 Gene:SHM2(YLR058C)|FD-Score:-3.15|P-value:8.10E-4||SGD DESC:Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis Gene:SHP1(YBL058W)|FD-Score:-3.95|P-value:3.92E-5||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate Gene:SIP2(YGL208W)|FD-Score:5.22|P-value:8.94E-8||SGD DESC:One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane Gene:SLZ1(YNL196C_p)|FD-Score:-3.45|P-value:2.85E-4||SGD DESC:Sporulation-specific protein with a leucine zipper motif Gene:SPO75(YLL005C)|FD-Score:-4.48|P-value:3.72E-6||SGD DESC:Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis Gene:SPR3(YGR059W)|FD-Score:4.11|P-value:1.96E-5||SGD DESC:Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI Gene:SPS2(YDR522C)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component Gene:SUC2(YIL162W)|FD-Score:3.34|P-value:4.16E-4||SGD DESC:Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively Gene:THI2(YBR240C)|FD-Score:3.26|P-value:5.59E-4||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:THI74(YDR438W)|FD-Score:3.12|P-value:8.91E-4||SGD DESC:Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication Gene:TMA108(YIL137C)|FD-Score:3.19|P-value:7.11E-4||SGD DESC:Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease Gene:TOF1(YNL273W)|FD-Score:3.26|P-value:5.55E-4||SGD DESC:Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase Gene:TSA1(YML028W)|FD-Score:3.2|P-value:6.90E-4||SGD DESC:Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress Gene:TVP38(YKR088C)|FD-Score:3.13|P-value:8.64E-4||SGD DESC:Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YBL059W(YBL059W_p)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication Gene:YCL001W-B(YCL001W-B_p)|FD-Score:-3.95|P-value:3.83E-5||SGD DESC:Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication Gene:YCR095W-A(YCR095W-A_p)|FD-Score:3.78|P-value:7.77E-5||SGD DESC:Putative protein of unknown function Gene:YCR102C(YCR102C_p)|FD-Score:4.88|P-value:5.27E-7||SGD DESC:Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family Gene:YDR344C(YDR344C_d)|FD-Score:5.22|P-value:8.79E-8||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YFL051C(YFL051C_p)|FD-Score:4.03|P-value:2.80E-5||SGD DESC:Putative protein of unknown function; YFL051C is not an essential gene Gene:YGL109W(YGL109W_d)|FD-Score:4.56|P-value:2.57E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Gene:YGR130C(YGR130C)|FD-Score:3.21|P-value:6.56E-4||SGD DESC:Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) Gene:YGR237C(YGR237C_p)|FD-Score:-3.4|P-value:3.37E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YJL175W(YJL175W_d)|FD-Score:-4.83|P-value:6.68E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor Gene:YMR013W-A(YMR013W-A_d)|FD-Score:-3.23|P-value:6.12E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73 Gene:YMR265C(YMR265C_p)|FD-Score:-3.7|P-value:1.09E-4||SGD DESC:Putative protein of unknown function Gene:YOL106W(YOL106W_d)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR263C(YOR263C_d)|FD-Score:3.88|P-value:5.31E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W Gene:YOR314W(YOR314W_d)|FD-Score:-3.92|P-value:4.50E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPR071W(YPR071W_p)|FD-Score:3.96|P-value:3.69E-5||SGD DESC:Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C Gene:AFG1(YEL052W)|FD-Score:-3.54|P-value:1.97E-4||SGD DESC:Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain Gene:AFI1(YOR129C)|FD-Score:3.16|P-value:7.78E-4||SGD DESC:Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p Gene:ASF1(YJL115W)|FD-Score:-6.23|P-value:2.27E-10||SGD DESC:Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition Gene:ATG8(YBL078C)|FD-Score:4.36|P-value:6.46E-6||SGD DESC:Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis Gene:BGL2(YGR282C)|FD-Score:4.91|P-value:4.46E-7||SGD DESC:Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance Gene:BLS1(YLR408C_p)|FD-Score:3.8|P-value:7.32E-5||SGD DESC:Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene Gene:BTN2(YGR142W)|FD-Score:3.15|P-value:8.07E-4||SGD DESC:v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication Gene:CDC73(YLR418C)|FD-Score:3.25|P-value:5.86E-4||SGD DESC:Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress Gene:FAU1(YER183C)|FD-Score:3.12|P-value:9.13E-4||SGD DESC:5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis Gene:GRE3(YHR104W)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress Gene:HAL5(YJL165C)|FD-Score:-3.16|P-value:7.99E-4||SGD DESC:Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication Gene:IRC14(YOR135C_d)|FD-Score:4.73|P-value:1.15E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci Gene:IRC25(YLR021W)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:KIN82(YCR091W)|FD-Score:3.19|P-value:7.15E-4||SGD DESC:Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p Gene:MAC1(YMR021C)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MAD2(YJL030W)|FD-Score:4.11|P-value:1.97E-5||SGD DESC:Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I Gene:MDS3(YGL197W)|FD-Score:3.78|P-value:7.89E-5||SGD DESC:Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain Gene:MEP1(YGR121C)|FD-Score:3.91|P-value:4.55E-5||SGD DESC:Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation Gene:MUP3(YHL036W)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:Low affinity methionine permease, similar to Mup1p Gene:PBP1(YGR178C)|FD-Score:3.27|P-value:5.39E-4||SGD DESC:Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:RCR1(YBR005W)|FD-Score:-3.57|P-value:1.81E-4||SGD DESC:Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication Gene:RPS16A(YMR143W)|FD-Score:-3.14|P-value:8.44E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication Gene:RPS22A(YJL190C)|FD-Score:5.27|P-value:6.77E-8||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication Gene:RPS4B(YHR203C)|FD-Score:-3.71|P-value:1.04E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication Gene:RRM3(YHR031C)|FD-Score:5.33|P-value:4.93E-8||SGD DESC:DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Gene:RRT6(YGL146C_p)|FD-Score:-3.24|P-value:6.02E-4||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins Gene:SDC1(YDR469W)|FD-Score:3.41|P-value:3.22E-4||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 Gene:SHM2(YLR058C)|FD-Score:-3.15|P-value:8.10E-4||SGD DESC:Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis Gene:SHP1(YBL058W)|FD-Score:-3.95|P-value:3.92E-5||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate Gene:SIP2(YGL208W)|FD-Score:5.22|P-value:8.94E-8||SGD DESC:One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane Gene:SLZ1(YNL196C_p)|FD-Score:-3.45|P-value:2.85E-4||SGD DESC:Sporulation-specific protein with a leucine zipper motif Gene:SPO75(YLL005C)|FD-Score:-4.48|P-value:3.72E-6||SGD DESC:Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis Gene:SPR3(YGR059W)|FD-Score:4.11|P-value:1.96E-5||SGD DESC:Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI Gene:SPS2(YDR522C)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component Gene:SUC2(YIL162W)|FD-Score:3.34|P-value:4.16E-4||SGD DESC:Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively Gene:THI2(YBR240C)|FD-Score:3.26|P-value:5.59E-4||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:THI74(YDR438W)|FD-Score:3.12|P-value:8.91E-4||SGD DESC:Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication Gene:TMA108(YIL137C)|FD-Score:3.19|P-value:7.11E-4||SGD DESC:Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease Gene:TOF1(YNL273W)|FD-Score:3.26|P-value:5.55E-4||SGD DESC:Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase Gene:TSA1(YML028W)|FD-Score:3.2|P-value:6.90E-4||SGD DESC:Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress Gene:TVP38(YKR088C)|FD-Score:3.13|P-value:8.64E-4||SGD DESC:Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YBL059W(YBL059W_p)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication Gene:YCL001W-B(YCL001W-B_p)|FD-Score:-3.95|P-value:3.83E-5||SGD DESC:Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication Gene:YCR095W-A(YCR095W-A_p)|FD-Score:3.78|P-value:7.77E-5||SGD DESC:Putative protein of unknown function Gene:YCR102C(YCR102C_p)|FD-Score:4.88|P-value:5.27E-7||SGD DESC:Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family Gene:YDR344C(YDR344C_d)|FD-Score:5.22|P-value:8.79E-8||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YFL051C(YFL051C_p)|FD-Score:4.03|P-value:2.80E-5||SGD DESC:Putative protein of unknown function; YFL051C is not an essential gene Gene:YGL109W(YGL109W_d)|FD-Score:4.56|P-value:2.57E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Gene:YGR130C(YGR130C)|FD-Score:3.21|P-value:6.56E-4||SGD DESC:Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) Gene:YGR237C(YGR237C_p)|FD-Score:-3.4|P-value:3.37E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YJL175W(YJL175W_d)|FD-Score:-4.83|P-value:6.68E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor Gene:YMR013W-A(YMR013W-A_d)|FD-Score:-3.23|P-value:6.12E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73 Gene:YMR265C(YMR265C_p)|FD-Score:-3.7|P-value:1.09E-4||SGD DESC:Putative protein of unknown function Gene:YOL106W(YOL106W_d)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR263C(YOR263C_d)|FD-Score:3.88|P-value:5.31E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W Gene:YOR314W(YOR314W_d)|FD-Score:-3.92|P-value:4.50E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPR071W(YPR071W_p)|FD-Score:3.96|P-value:3.69E-5||SGD DESC:Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL247W7.173.77E-131.88BRR6Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism
YER038C5.783.81E-91.88KRE29Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
YBR160W3.904.84E-50.02CDC28Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress
YML010W3.885.25E-50.07SPT5Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair
YFL029C3.817.02E-50.16CAK1Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases
YMR235C3.651.31E-40.02RNA1GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
YER133W3.621.45E-40.04GLC7Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
YFR031C3.581.69E-40.06SMC2Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
YNL287W3.532.11E-40.05SEC21Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
YOR282W_d3.482.54E-40.09YOR282W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
YJL033W3.383.56E-40.05HCA4DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
YAL025C3.344.24E-40.03MAK16Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YIL051C3.304.78E-40.06MMF1Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
YKR083C3.255.81E-40.10DAD2Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YDR292C3.158.09E-40.28SRP101Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YHR031C5.334.93E-8RRM3DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
YJL190C5.276.77E-8RPS22AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication
YDR344C_d5.228.79E-8YDR344C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL208W5.228.94E-8SIP2One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
YGR282C4.914.46E-7BGL2Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
YCR102C_p4.885.27E-7YCR102C_pPutative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family
YOR135C_d4.731.15E-6IRC14_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci
YGL109W_d4.562.57E-6YGL109W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
YBL078C4.366.46E-6ATG8Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis
YGR059W4.111.96E-5SPR3Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI
YJL030W4.111.97E-5MAD2Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I
YFL051C_p4.032.80E-5YFL051C_pPutative protein of unknown function; YFL051C is not an essential gene
YPR071W_p3.963.69E-5YPR071W_pPutative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C
YGR121C3.914.55E-5MEP1Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YOR263C_d3.885.31E-5YOR263C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W

GO enrichment analysis for SGTC_2392
biological processes

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0871.92E-11SGTC_23699071472 200.0 μMChembridge (Fragment library)172960370.0701754
0.0856.11E-11SGTC_21996590217 200.0 μMChembridge (Fragment library)7031090.107692mitochondrial processes
0.0841.19E-10SGTC_1685st024049 53.1 μMTimTec (Natural product derivative library)19411390.12987TSC3-RPN4
0.0656.09E-7SGTC_23809035439 200.0 μMChembridge (Fragment library)64625750.0701754endomembrane recycling
0.0631.05E-6SGTC_8400245-0196 390.0 μMChemDiv (Drug-like library)38275280.0985916
0.0622.13E-6SGTC_13241418-0026 34.4 μMChemDiv (Drug-like library)13725130.111111
0.0603.56E-6SGTC_20104012422 159.0 μMChembridge (Fragment library)9523930.122807
0.0604.49E-6SGTC_1553gossypol 38.6 μMTimTec (Pure natural product library)35030.0615385
0.0589.42E-6SGTC_1959st077091 55.8 μMTimTec (Natural product derivative library)8213560.0895522RPP1 & pyrimidine depletion
0.0543.29E-5SGTC_31829108849 49.5 μMChembridge (Drug-like library)171330450.254237RPP1 & pyrimidine depletion
0.0543.60E-5SGTC_1776st049249 45.9 μMTimTec (Natural product derivative library)18223140.0921053
0.0534.88E-5SGTC_23427990637 118.9 μMChembridge (Fragment library)20331020.107692RNA processing & uracil transport
0.0526.53E-5SGTC_30989119039 49.5 μMChembridge (Drug-like library)171615280.262295Golgi
0.0526.72E-5SGTC_23879077560 195.1 μMChembridge (Fragment library)53032720.0833333
0.0517.51E-5SGTC_29249010168 62.8 μMChembridge (Drug-like library)29939290.171875cell wall signaling

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_2942905277762.25 μM0.4583336469503Chembridge (Drug-like library)284.1131234.14912
SGTC_2787528454071.43 μM0.44736958Chembridge (Drug-like library)291.729563.24613
SGTC_1190121-004324.82 μM0.4313731092378ChemDiv (Drug-like library)405.469124.53322mitochondrial stress
SGTC_2890904672958.44 μM0.431373903329Chembridge (Drug-like library)270.114662.88412Golgi
SGTC_3176910658249.47 μM0.42307717018027Chembridge (Drug-like library)275.730163.74812
SGTC_2900532852885.29 μM0.42795359Chembridge (Drug-like library)261.703583.26212Golgi
SGTC_7161683-5115658 μM0.396226723597ChemDiv (Drug-like library)303.740263.48313
SGTC_3188911078949.47 μM0.396226849217Chembridge (Drug-like library)275.730163.61112iron homeostasis
SGTC_12550566-0045221 μM0.3921572788469ChemDiv (Drug-like library)304.728323.04223excess fatty acid
SGTC_2867903909871.43 μM0.3756463460Chembridge (Drug-like library)287.740863.87912iron homeostasis