Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPR165W | 12.90 | 1.99E-38 | 5.62 | RHO1 | GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) |
YOL144W | 7.29 | 1.55E-13 | 0.05 | NOP8 | Nucleolar protein required for 60S ribosomal subunit biogenesis |
YNL178W | 7.24 | 2.31E-13 | 0.75 | RPS3 | Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 |
YHR101C | 6.48 | 4.47E-11 | 0.20 | BIG1 | Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan |
YIL142W | 6.29 | 1.62E-10 | 0.02 | CCT2 | Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YGR115C_d | 6.26 | 1.87E-10 | 0.49 | YGR115C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C |
YKL088W | 5.78 | 3.80E-9 | 0.05 | CAB3 | Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC |
YMR200W | 5.73 | 4.99E-9 | 0.27 | ROT1 | Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation |
YDL147W | 5.46 | 2.33E-8 | 0.69 | RPN5 | Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein |
YMR146C | 4.78 | 8.97E-7 | 0.06 | TIF34 | eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation |
YFR004W | 4.71 | 1.23E-6 | 0.14 | RPN11 | Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress |
YOL139C | 4.57 | 2.48E-6 | 0.05 | CDC33 | mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth |
YLR197W | 4.52 | 3.14E-6 | 0.07 | NOP56 | Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects |
YGR116W | 4.45 | 4.34E-6 | 0.13 | SPT6 | Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region |
YNR035C | 4.32 | 7.74E-6 | 0.11 | ARC35 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin |