Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGL099W | 8.77 | 9.09E-19 | 2.54 | LSG1 | Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm |
YLR314C | 6.23 | 2.30E-10 | 0.43 | CDC3 | Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells |
YBR088C | 5.80 | 3.36E-9 | 0.73 | POL30 | Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair |
YHR170W | 5.06 | 2.06E-7 | 0.41 | NMD3 | Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex |
YFR028C | 4.65 | 1.63E-6 | 0.14 | CDC14 | Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis |
YOR204W | 4.52 | 3.16E-6 | 0.28 | DED1 | ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility |
YPL175W | 4.24 | 1.14E-5 | 0.35 | SPT14 | UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins |
YDL031W | 3.89 | 5.11E-5 | 0.03 | DBP10 | Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis |
YGL137W | 3.86 | 5.76E-5 | 0.11 | SEC27 | Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP |
YDR224C | 3.74 | 9.05E-5 | 0.13 | HTB1 | Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation |
YDR302W | 3.62 | 1.48E-4 | 0.12 | GPI11 | ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog |
YOR361C | 3.50 | 2.36E-4 | 0.05 | PRT1 | eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes |
YDL029W | 3.44 | 2.88E-4 | 0.07 | ARP2 | Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity |
YGL150C | 3.38 | 3.66E-4 | 0.15 | INO80 | ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription |
YPR086W | 3.23 | 6.19E-4 | 0.04 | SUA7 | Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II |