Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR058C-A | 34.60 | 8.09E-263 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YOR323C | 20.40 | 1.42E-92 | PRO2 | Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis |
YDR126W | 18.20 | 3.34E-74 | SWF1 | Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion |
YER074W | 16.00 | 4.71E-58 | RPS24A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication |
YAL024C | 15.90 | 3.48E-57 | LTE1 | Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures |
YGL012W | 13.60 | 2.72E-42 | ERG4 | C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol |
YFR036W | 11.80 | 1.25E-32 | CDC26 | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition |
YJL101C | 11.40 | 2.21E-30 | GSH1 | Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress |
YNL298W | 11.40 | 2.30E-30 | CLA4 | Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p |
YHR100C | 10.40 | 1.23E-25 | GEP4 | Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT |
YPL091W | 9.36 | 4.01E-21 | GLR1 | Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress |
YHR193C | 9.15 | 2.75E-20 | EGD2 | Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes |
YDR129C | 8.86 | 4.11E-19 | SAC6 | Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress |
YKL090W | 8.80 | 6.85E-19 | CUE2 | Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination |
YDR260C | 8.71 | 1.52E-18 | SWM1 | Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation |