paclitaxel FDA approved compound

Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase

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PubChem MeSH terms: Antineoplastic Agents, Phytogenic;Tubulin Modulators



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2407
Screen concentration 400.0 μM
Source Miscellaneous
PubChem CID 4666
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Standardized SMILES CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(=O)C)C2C(OC(=O)c4ccccc4)C5(O)CC(OC(=O)C(O)C(NC(=O)c6ccccc6)c7ccccc7)C(=C1C5(C)C)C
Molecular weight 853.9061
ALogP 3.06
H-bond donor count 4
H-bond acceptor count 14
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.7
% growth inhibition (Hom. pool) -3.53


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4666
Download HIP data (tab-delimited text)  (excel)
Gene:CDC27(YBL084C)|FD-Score:-4.9|P-value:4.91E-7|Clearance:0||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:COG3(YER157W)|FD-Score:7.71|P-value:6.29E-15|Clearance:3.1||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DBP5(YOR046C)|FD-Score:3.1|P-value:9.80E-4|Clearance:0.07||SGD DESC:Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p Gene:DSN1(YIR010W)|FD-Score:-4.49|P-value:3.55E-6|Clearance:0||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation Gene:ENP1(YBR247C)|FD-Score:3.2|P-value:6.97E-4|Clearance:0.1||SGD DESC:Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus Gene:HRR25(YPL204W)|FD-Score:-4.7|P-value:1.32E-6|Clearance:0||SGD DESC:Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) Gene:MAS2(YHR024C)|FD-Score:-3.95|P-value:3.94E-5|Clearance:0||SGD DESC:Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:NUD1(YOR373W)|FD-Score:-3.17|P-value:7.60E-4|Clearance:0||SGD DESC:Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance Gene:PCM1(YEL058W)|FD-Score:4.61|P-value:2.02E-6|Clearance:0.11||SGD DESC:Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors Gene:PFY1(YOR122C)|FD-Score:-3.12|P-value:9.04E-4|Clearance:0||SGD DESC:Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress Gene:RCL1(YOL010W)|FD-Score:-3.82|P-value:6.72E-5|Clearance:0||SGD DESC:Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected Gene:REB1(YBR049C)|FD-Score:3.44|P-value:2.91E-4|Clearance:0.04||SGD DESC:RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication Gene:RIO2(YNL207W)|FD-Score:4.5|P-value:3.38E-6|Clearance:0.43||SGD DESC:Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p Gene:RPC82(YPR190C)|FD-Score:3.23|P-value:6.13E-4|Clearance:0.01||SGD DESC:RNA polymerase III subunit C82 Gene:RPF1(YHR088W)|FD-Score:4.05|P-value:2.56E-5|Clearance:0.13||SGD DESC:Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA Gene:RPS3(YNL178W)|FD-Score:3.4|P-value:3.41E-4|Clearance:0.16||SGD DESC:Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 Gene:SAM35(YHR083W)|FD-Score:-4.11|P-value:1.98E-5|Clearance:0||SGD DESC:Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane Gene:SEC1(YDR164C)|FD-Score:3.68|P-value:1.16E-4|Clearance:0.24||SGD DESC:Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function Gene:SLU7(YDR088C)|FD-Score:3.92|P-value:4.38E-5|Clearance:0.2||SGD DESC:RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain Gene:SMT3(YDR510W)|FD-Score:3.22|P-value:6.40E-4|Clearance:0.01||SGD DESC:Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2 Gene:STH1(YIL126W)|FD-Score:3.72|P-value:9.90E-5|Clearance:0.04||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:TRR1(YDR353W)|FD-Score:-3.1|P-value:9.79E-4|Clearance:0||SGD DESC:Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication Gene:UTP22(YGR090W)|FD-Score:4.07|P-value:2.36E-5|Clearance:0.02||SGD DESC:Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals Gene:UTP23(YOR004W)|FD-Score:3.21|P-value:6.65E-4|Clearance:0.01||SGD DESC:Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein Gene:YPD1(YDL235C)|FD-Score:-4.57|P-value:2.45E-6|Clearance:0||SGD DESC:Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus Gene:CDC27(YBL084C)|FD-Score:-4.9|P-value:4.91E-7|Clearance:0||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:COG3(YER157W)|FD-Score:7.71|P-value:6.29E-15|Clearance:3.1||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DBP5(YOR046C)|FD-Score:3.1|P-value:9.80E-4|Clearance:0.07||SGD DESC:Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p Gene:DSN1(YIR010W)|FD-Score:-4.49|P-value:3.55E-6|Clearance:0||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation Gene:ENP1(YBR247C)|FD-Score:3.2|P-value:6.97E-4|Clearance:0.1||SGD DESC:Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus Gene:HRR25(YPL204W)|FD-Score:-4.7|P-value:1.32E-6|Clearance:0||SGD DESC:Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) Gene:MAS2(YHR024C)|FD-Score:-3.95|P-value:3.94E-5|Clearance:0||SGD DESC:Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:NUD1(YOR373W)|FD-Score:-3.17|P-value:7.60E-4|Clearance:0||SGD DESC:Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance Gene:PCM1(YEL058W)|FD-Score:4.61|P-value:2.02E-6|Clearance:0.11||SGD DESC:Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors Gene:PFY1(YOR122C)|FD-Score:-3.12|P-value:9.04E-4|Clearance:0||SGD DESC:Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress Gene:RCL1(YOL010W)|FD-Score:-3.82|P-value:6.72E-5|Clearance:0||SGD DESC:Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected Gene:REB1(YBR049C)|FD-Score:3.44|P-value:2.91E-4|Clearance:0.04||SGD DESC:RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication Gene:RIO2(YNL207W)|FD-Score:4.5|P-value:3.38E-6|Clearance:0.43||SGD DESC:Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p Gene:RPC82(YPR190C)|FD-Score:3.23|P-value:6.13E-4|Clearance:0.01||SGD DESC:RNA polymerase III subunit C82 Gene:RPF1(YHR088W)|FD-Score:4.05|P-value:2.56E-5|Clearance:0.13||SGD DESC:Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA Gene:RPS3(YNL178W)|FD-Score:3.4|P-value:3.41E-4|Clearance:0.16||SGD DESC:Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 Gene:SAM35(YHR083W)|FD-Score:-4.11|P-value:1.98E-5|Clearance:0||SGD DESC:Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane Gene:SEC1(YDR164C)|FD-Score:3.68|P-value:1.16E-4|Clearance:0.24||SGD DESC:Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function Gene:SLU7(YDR088C)|FD-Score:3.92|P-value:4.38E-5|Clearance:0.2||SGD DESC:RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain Gene:SMT3(YDR510W)|FD-Score:3.22|P-value:6.40E-4|Clearance:0.01||SGD DESC:Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2 Gene:STH1(YIL126W)|FD-Score:3.72|P-value:9.90E-5|Clearance:0.04||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:TRR1(YDR353W)|FD-Score:-3.1|P-value:9.79E-4|Clearance:0||SGD DESC:Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication Gene:UTP22(YGR090W)|FD-Score:4.07|P-value:2.36E-5|Clearance:0.02||SGD DESC:Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals Gene:UTP23(YOR004W)|FD-Score:3.21|P-value:6.65E-4|Clearance:0.01||SGD DESC:Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein Gene:YPD1(YDL235C)|FD-Score:-4.57|P-value:2.45E-6|Clearance:0||SGD DESC:Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4666
Download HOP data (tab-delimited text)  (excel)
Gene:ACB1(YGR037C)|FD-Score:6.7|P-value:1.08E-11||SGD DESC:Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress Gene:ACE2(YLR131C)|FD-Score:5.36|P-value:4.12E-8||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:AIM29(YKR074W)|FD-Score:3.86|P-value:5.73E-5||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss Gene:ALG6(YOR002W)|FD-Score:3.86|P-value:5.72E-5||SGD DESC:Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease Gene:APL5(YPL195W)|FD-Score:3.59|P-value:1.63E-4||SGD DESC:Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function Gene:APM2(YHL019C)|FD-Score:3.78|P-value:7.80E-5||SGD DESC:Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport Gene:ARX1(YDR101C)|FD-Score:-4.67|P-value:1.51E-6||SGD DESC:Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex Gene:ASF1(YJL115W)|FD-Score:5.23|P-value:8.53E-8||SGD DESC:Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition Gene:ATG7(YHR171W)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation Gene:BSC1(YDL037C)|FD-Score:-5.81|P-value:3.08E-9||SGD DESC:Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression Gene:CCW12(YLR110C)|FD-Score:3.28|P-value:5.22E-4||SGD DESC:Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication Gene:CMC4(YMR194C-B)|FD-Score:4.9|P-value:4.80E-7||SGD DESC:Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs Gene:COX5A(YNL052W)|FD-Score:3.92|P-value:4.47E-5||SGD DESC:Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication Gene:CPA1(YOR303W)|FD-Score:4.11|P-value:2.00E-5||SGD DESC:Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader Gene:CTS1(YLR286C)|FD-Score:4.18|P-value:1.43E-5||SGD DESC:Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p Gene:CYC7(YEL039C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication Gene:DAL4(YIR028W)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation Gene:DIT2(YDR402C)|FD-Score:-5.57|P-value:1.24E-8||SGD DESC:N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s Gene:DPH2(YKL191W)|FD-Score:3.92|P-value:4.42E-5||SGD DESC:Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p Gene:ELP4(YPL101W)|FD-Score:3.21|P-value:6.65E-4||SGD DESC:Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity Gene:ERG3(YLR056W)|FD-Score:3.32|P-value:4.54E-4||SGD DESC:C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase Gene:ETP1(YHL010C)|FD-Score:3.91|P-value:4.57E-5||SGD DESC:Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences Gene:FIT2(YOR382W)|FD-Score:3.3|P-value:4.82E-4||SGD DESC:Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall Gene:GCY1(YOR120W)|FD-Score:3.14|P-value:8.44E-4||SGD DESC:Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication Gene:GDH1(YOR375C)|FD-Score:5.11|P-value:1.63E-7||SGD DESC:NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication Gene:GFD2(YCL036W)|FD-Score:6.35|P-value:1.06E-10||SGD DESC:Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication Gene:GIR2(YDR152W)|FD-Score:-4.83|P-value:6.92E-7||SGD DESC:Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein Gene:GUF1(YLR289W)|FD-Score:4.17|P-value:1.52E-5||SGD DESC:Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor Gene:HBT1(YDL223C)|FD-Score:-3.18|P-value:7.48E-4||SGD DESC:Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis Gene:HRD3(YLR207W)|FD-Score:4.93|P-value:4.17E-7||SGD DESC:Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events Gene:ICL1(YER065C)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose Gene:IMA1(YGR287C)|FD-Score:3.21|P-value:6.53E-4||SGD DESC:Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family Gene:IXR1(YKL032C)|FD-Score:7.99|P-value:6.73E-16||SGD DESC:Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b Gene:KIN3(YAR018C)|FD-Score:3.62|P-value:1.47E-4||SGD DESC:Nonessential serine/threonine protein kinase; possible role in DNA damage response Gene:LEO1(YOR123C)|FD-Score:-3.29|P-value:4.98E-4||SGD DESC:Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:LOT6(YLR011W)|FD-Score:3.81|P-value:6.96E-5||SGD DESC:FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions Gene:MGM1(YOR211C)|FD-Score:3.3|P-value:4.85E-4||SGD DESC:Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy Gene:MRP1(YDR347W)|FD-Score:3.17|P-value:7.51E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein Gene:MRPS8(YMR158W)|FD-Score:4.26|P-value:1.01E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSI1(YBR195C)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase Gene:MTC7(YEL033W_p)|FD-Score:4.72|P-value:1.19E-6||SGD DESC:Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant Gene:OXA1(YER154W)|FD-Score:-4.13|P-value:1.81E-5||SGD DESC:Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals Gene:OYE2(YHR179W)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress Gene:PAN3(YKL025C)|FD-Score:9.08|P-value:5.48E-20||SGD DESC:Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes Gene:PBP4(YDL053C)|FD-Score:6.98|P-value:1.46E-12||SGD DESC:Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress Gene:PDA1(YER178W)|FD-Score:-3.97|P-value:3.65E-5||SGD DESC:E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose Gene:PET130(YJL023C)|FD-Score:-3.25|P-value:5.78E-4||SGD DESC:Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:PEX10(YDR265W)|FD-Score:5.63|P-value:8.91E-9||SGD DESC:Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders Gene:PEX17(YNL214W)|FD-Score:3.37|P-value:3.72E-4||SGD DESC:Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis Gene:PHO23(YNL097C)|FD-Score:3.28|P-value:5.13E-4||SGD DESC:Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 Gene:PHO4(YFR034C)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability Gene:PHO89(YBR296C)|FD-Score:3.35|P-value:3.99E-4||SGD DESC:Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification Gene:POR1(YNL055C)|FD-Score:3.88|P-value:5.26E-5||SGD DESC:Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication Gene:PRY3(YJL078C)|FD-Score:4.51|P-value:3.25E-6||SGD DESC:Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p Gene:PTC3(YBL056W)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication Gene:RCN2(YOR220W_p)|FD-Score:-5.16|P-value:1.22E-7||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress Gene:RDL2(YOR286W)|FD-Score:-3.15|P-value:8.09E-4||SGD DESC:Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss Gene:REH1(YLR387C)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains Gene:RGC1(YPR115W)|FD-Score:3.97|P-value:3.52E-5||SGD DESC:Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication Gene:RPL23A(YBL087C)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication Gene:RPN13(YLR421C)|FD-Score:-4.1|P-value:2.07E-5||SGD DESC:Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress Gene:SBA1(YKL117W)|FD-Score:-3.36|P-value:3.93E-4||SGD DESC:Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress Gene:SEF1(YBL066C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Putative transcription factor, has homolog in Kluyveromyces lactis Gene:SKY1(YMR216C)|FD-Score:5.1|P-value:1.68E-7||SGD DESC:SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 Gene:SNZ2(YNL333W)|FD-Score:-5.03|P-value:2.45E-7||SGD DESC:Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p Gene:SPP1(YPL138C)|FD-Score:4.1|P-value:2.10E-5||SGD DESC:Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein Gene:SRB2(YHR041C)|FD-Score:4.51|P-value:3.30E-6||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance Gene:SSN2(YDR443C)|FD-Score:3.23|P-value:6.19E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation Gene:SUR4(YLR372W)|FD-Score:4.52|P-value:3.03E-6||SGD DESC:Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis Gene:SWR1(YDR334W)|FD-Score:3.28|P-value:5.12E-4||SGD DESC:Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:SYN8(YAL014C)|FD-Score:4.74|P-value:1.07E-6||SGD DESC:Endosomal SNARE related to mammalian syntaxin 8 Gene:TAX4(YJL083W)|FD-Score:4.77|P-value:9.22E-7||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication Gene:TFB5(YDR079C-A)|FD-Score:9.18|P-value:2.09E-20||SGD DESC:Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair Gene:VAC14(YLR386W)|FD-Score:4.37|P-value:6.34E-6||SGD DESC:Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p Gene:WAR1(YML076C)|FD-Score:-3.27|P-value:5.39E-4||SGD DESC:Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively Gene:YBL044W(YBL044W_p)|FD-Score:-3.15|P-value:8.03E-4||SGD DESC:Putative protein of unknown function; YBL044W is not an essential protein Gene:YBR196C-A(YBR196C-A_p)|FD-Score:3.21|P-value:6.71E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR219C(YBR219C_p)|FD-Score:-4.05|P-value:2.61E-5||SGD DESC:Putative protein of unknown function; YBR219C is not an essential gene Gene:YBR259W(YBR259W_p)|FD-Score:5.45|P-value:2.52E-8||SGD DESC:Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress Gene:YCR015C(YCR015C_p)|FD-Score:5.91|P-value:1.71E-9||SGD DESC:Putative protein of unknown function; YCR015C is not an essential gene Gene:YDR090C(YDR090C_p)|FD-Score:-6.18|P-value:3.24E-10||SGD DESC:Putative protein of unknown function Gene:YDR194W-A(YDR194W-A_p)|FD-Score:-3.09|P-value:9.88E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR210W(YDR210W_p)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:YEH2(YLR020C)|FD-Score:4.09|P-value:2.15E-5||SGD DESC:Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism Gene:YER068C-A(YER068C-A_d)|FD-Score:-3.32|P-value:4.55E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER087C-A(YER087C-A_d)|FD-Score:10.2|P-value:1.48E-24||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase Gene:YGL015C(YGL015C_p)|FD-Score:-4.33|P-value:7.33E-6||SGD DESC:Putative protein of unknown function; null mutants accumulate cargo in the Golgi Gene:YIL032C(YIL032C_d)|FD-Score:3.97|P-value:3.59E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIR043C(YIR043C)|FD-Score:-4.72|P-value:1.17E-6||SGD DESC:Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family Gene:YJR107W(YJR107W_p)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Putative lipase Gene:YJR154W(YJR154W_p)|FD-Score:3.53|P-value:2.11E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YLL044W(YLL044W_d)|FD-Score:10.1|P-value:1.77E-24||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant Gene:YLR413W(YLR413W_p)|FD-Score:3.21|P-value:6.74E-4||SGD DESC:Putative protein of unknown function; YLR413W is not an essential gene Gene:YMR102C(YMR102C_p)|FD-Score:3.83|P-value:6.39E-5||SGD DESC:Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene Gene:YMR141C(YMR141C_d)|FD-Score:-3.65|P-value:1.29E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL024C(YNL024C_p)|FD-Score:-3.22|P-value:6.37E-4||SGD DESC:Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern Gene:YNL200C(YNL200C)|FD-Score:3.15|P-value:8.13E-4||SGD DESC:NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOL024W(YOL024W_p)|FD-Score:-3.41|P-value:3.24E-4||SGD DESC:Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication Gene:YOR029W(YOR029W_d)|FD-Score:3.72|P-value:9.94E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR050C(YOR050C_d)|FD-Score:3.24|P-value:6.06E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable Gene:YOR228C(YOR228C)|FD-Score:-3.22|P-value:6.52E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YOR342C(YOR342C_p)|FD-Score:3.27|P-value:5.39E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication Gene:YPL260W(YPL260W_p)|FD-Score:-3.33|P-value:4.40E-4||SGD DESC:Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YPR147C(YPR147C_p)|FD-Score:-3.57|P-value:1.79E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS Gene:YPR153W(YPR153W)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Putative protein of unknown function Gene:YRA2(YKL214C)|FD-Score:4.21|P-value:1.27E-5||SGD DESC:Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus Gene:YTA6(YPL074W)|FD-Score:-3.74|P-value:9.04E-5||SGD DESC:Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress Gene:ACB1(YGR037C)|FD-Score:6.7|P-value:1.08E-11||SGD DESC:Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress Gene:ACE2(YLR131C)|FD-Score:5.36|P-value:4.12E-8||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:AIM29(YKR074W)|FD-Score:3.86|P-value:5.73E-5||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss Gene:ALG6(YOR002W)|FD-Score:3.86|P-value:5.72E-5||SGD DESC:Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease Gene:APL5(YPL195W)|FD-Score:3.59|P-value:1.63E-4||SGD DESC:Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function Gene:APM2(YHL019C)|FD-Score:3.78|P-value:7.80E-5||SGD DESC:Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport Gene:ARX1(YDR101C)|FD-Score:-4.67|P-value:1.51E-6||SGD DESC:Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex Gene:ASF1(YJL115W)|FD-Score:5.23|P-value:8.53E-8||SGD DESC:Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition Gene:ATG7(YHR171W)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation Gene:BSC1(YDL037C)|FD-Score:-5.81|P-value:3.08E-9||SGD DESC:Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression Gene:CCW12(YLR110C)|FD-Score:3.28|P-value:5.22E-4||SGD DESC:Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication Gene:CMC4(YMR194C-B)|FD-Score:4.9|P-value:4.80E-7||SGD DESC:Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs Gene:COX5A(YNL052W)|FD-Score:3.92|P-value:4.47E-5||SGD DESC:Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication Gene:CPA1(YOR303W)|FD-Score:4.11|P-value:2.00E-5||SGD DESC:Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader Gene:CTS1(YLR286C)|FD-Score:4.18|P-value:1.43E-5||SGD DESC:Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p Gene:CYC7(YEL039C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication Gene:DAL4(YIR028W)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation Gene:DIT2(YDR402C)|FD-Score:-5.57|P-value:1.24E-8||SGD DESC:N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s Gene:DPH2(YKL191W)|FD-Score:3.92|P-value:4.42E-5||SGD DESC:Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p Gene:ELP4(YPL101W)|FD-Score:3.21|P-value:6.65E-4||SGD DESC:Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity Gene:ERG3(YLR056W)|FD-Score:3.32|P-value:4.54E-4||SGD DESC:C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase Gene:ETP1(YHL010C)|FD-Score:3.91|P-value:4.57E-5||SGD DESC:Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences Gene:FIT2(YOR382W)|FD-Score:3.3|P-value:4.82E-4||SGD DESC:Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall Gene:GCY1(YOR120W)|FD-Score:3.14|P-value:8.44E-4||SGD DESC:Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication Gene:GDH1(YOR375C)|FD-Score:5.11|P-value:1.63E-7||SGD DESC:NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication Gene:GFD2(YCL036W)|FD-Score:6.35|P-value:1.06E-10||SGD DESC:Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication Gene:GIR2(YDR152W)|FD-Score:-4.83|P-value:6.92E-7||SGD DESC:Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein Gene:GUF1(YLR289W)|FD-Score:4.17|P-value:1.52E-5||SGD DESC:Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor Gene:HBT1(YDL223C)|FD-Score:-3.18|P-value:7.48E-4||SGD DESC:Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis Gene:HRD3(YLR207W)|FD-Score:4.93|P-value:4.17E-7||SGD DESC:Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events Gene:ICL1(YER065C)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose Gene:IMA1(YGR287C)|FD-Score:3.21|P-value:6.53E-4||SGD DESC:Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family Gene:IXR1(YKL032C)|FD-Score:7.99|P-value:6.73E-16||SGD DESC:Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b Gene:KIN3(YAR018C)|FD-Score:3.62|P-value:1.47E-4||SGD DESC:Nonessential serine/threonine protein kinase; possible role in DNA damage response Gene:LEO1(YOR123C)|FD-Score:-3.29|P-value:4.98E-4||SGD DESC:Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:LOT6(YLR011W)|FD-Score:3.81|P-value:6.96E-5||SGD DESC:FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions Gene:MGM1(YOR211C)|FD-Score:3.3|P-value:4.85E-4||SGD DESC:Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy Gene:MRP1(YDR347W)|FD-Score:3.17|P-value:7.51E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein Gene:MRPS8(YMR158W)|FD-Score:4.26|P-value:1.01E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSI1(YBR195C)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase Gene:MTC7(YEL033W_p)|FD-Score:4.72|P-value:1.19E-6||SGD DESC:Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant Gene:OXA1(YER154W)|FD-Score:-4.13|P-value:1.81E-5||SGD DESC:Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals Gene:OYE2(YHR179W)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress Gene:PAN3(YKL025C)|FD-Score:9.08|P-value:5.48E-20||SGD DESC:Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes Gene:PBP4(YDL053C)|FD-Score:6.98|P-value:1.46E-12||SGD DESC:Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress Gene:PDA1(YER178W)|FD-Score:-3.97|P-value:3.65E-5||SGD DESC:E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose Gene:PET130(YJL023C)|FD-Score:-3.25|P-value:5.78E-4||SGD DESC:Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:PEX10(YDR265W)|FD-Score:5.63|P-value:8.91E-9||SGD DESC:Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders Gene:PEX17(YNL214W)|FD-Score:3.37|P-value:3.72E-4||SGD DESC:Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis Gene:PHO23(YNL097C)|FD-Score:3.28|P-value:5.13E-4||SGD DESC:Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 Gene:PHO4(YFR034C)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability Gene:PHO89(YBR296C)|FD-Score:3.35|P-value:3.99E-4||SGD DESC:Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification Gene:POR1(YNL055C)|FD-Score:3.88|P-value:5.26E-5||SGD DESC:Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication Gene:PRY3(YJL078C)|FD-Score:4.51|P-value:3.25E-6||SGD DESC:Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p Gene:PTC3(YBL056W)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication Gene:RCN2(YOR220W_p)|FD-Score:-5.16|P-value:1.22E-7||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress Gene:RDL2(YOR286W)|FD-Score:-3.15|P-value:8.09E-4||SGD DESC:Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss Gene:REH1(YLR387C)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains Gene:RGC1(YPR115W)|FD-Score:3.97|P-value:3.52E-5||SGD DESC:Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication Gene:RPL23A(YBL087C)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication Gene:RPN13(YLR421C)|FD-Score:-4.1|P-value:2.07E-5||SGD DESC:Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress Gene:SBA1(YKL117W)|FD-Score:-3.36|P-value:3.93E-4||SGD DESC:Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress Gene:SEF1(YBL066C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Putative transcription factor, has homolog in Kluyveromyces lactis Gene:SKY1(YMR216C)|FD-Score:5.1|P-value:1.68E-7||SGD DESC:SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 Gene:SNZ2(YNL333W)|FD-Score:-5.03|P-value:2.45E-7||SGD DESC:Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p Gene:SPP1(YPL138C)|FD-Score:4.1|P-value:2.10E-5||SGD DESC:Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein Gene:SRB2(YHR041C)|FD-Score:4.51|P-value:3.30E-6||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance Gene:SSN2(YDR443C)|FD-Score:3.23|P-value:6.19E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation Gene:SUR4(YLR372W)|FD-Score:4.52|P-value:3.03E-6||SGD DESC:Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis Gene:SWR1(YDR334W)|FD-Score:3.28|P-value:5.12E-4||SGD DESC:Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:SYN8(YAL014C)|FD-Score:4.74|P-value:1.07E-6||SGD DESC:Endosomal SNARE related to mammalian syntaxin 8 Gene:TAX4(YJL083W)|FD-Score:4.77|P-value:9.22E-7||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication Gene:TFB5(YDR079C-A)|FD-Score:9.18|P-value:2.09E-20||SGD DESC:Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair Gene:VAC14(YLR386W)|FD-Score:4.37|P-value:6.34E-6||SGD DESC:Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p Gene:WAR1(YML076C)|FD-Score:-3.27|P-value:5.39E-4||SGD DESC:Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively Gene:YBL044W(YBL044W_p)|FD-Score:-3.15|P-value:8.03E-4||SGD DESC:Putative protein of unknown function; YBL044W is not an essential protein Gene:YBR196C-A(YBR196C-A_p)|FD-Score:3.21|P-value:6.71E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR219C(YBR219C_p)|FD-Score:-4.05|P-value:2.61E-5||SGD DESC:Putative protein of unknown function; YBR219C is not an essential gene Gene:YBR259W(YBR259W_p)|FD-Score:5.45|P-value:2.52E-8||SGD DESC:Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress Gene:YCR015C(YCR015C_p)|FD-Score:5.91|P-value:1.71E-9||SGD DESC:Putative protein of unknown function; YCR015C is not an essential gene Gene:YDR090C(YDR090C_p)|FD-Score:-6.18|P-value:3.24E-10||SGD DESC:Putative protein of unknown function Gene:YDR194W-A(YDR194W-A_p)|FD-Score:-3.09|P-value:9.88E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR210W(YDR210W_p)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:YEH2(YLR020C)|FD-Score:4.09|P-value:2.15E-5||SGD DESC:Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism Gene:YER068C-A(YER068C-A_d)|FD-Score:-3.32|P-value:4.55E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER087C-A(YER087C-A_d)|FD-Score:10.2|P-value:1.48E-24||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase Gene:YGL015C(YGL015C_p)|FD-Score:-4.33|P-value:7.33E-6||SGD DESC:Putative protein of unknown function; null mutants accumulate cargo in the Golgi Gene:YIL032C(YIL032C_d)|FD-Score:3.97|P-value:3.59E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIR043C(YIR043C)|FD-Score:-4.72|P-value:1.17E-6||SGD DESC:Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family Gene:YJR107W(YJR107W_p)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Putative lipase Gene:YJR154W(YJR154W_p)|FD-Score:3.53|P-value:2.11E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YLL044W(YLL044W_d)|FD-Score:10.1|P-value:1.77E-24||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant Gene:YLR413W(YLR413W_p)|FD-Score:3.21|P-value:6.74E-4||SGD DESC:Putative protein of unknown function; YLR413W is not an essential gene Gene:YMR102C(YMR102C_p)|FD-Score:3.83|P-value:6.39E-5||SGD DESC:Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene Gene:YMR141C(YMR141C_d)|FD-Score:-3.65|P-value:1.29E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL024C(YNL024C_p)|FD-Score:-3.22|P-value:6.37E-4||SGD DESC:Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern Gene:YNL200C(YNL200C)|FD-Score:3.15|P-value:8.13E-4||SGD DESC:NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOL024W(YOL024W_p)|FD-Score:-3.41|P-value:3.24E-4||SGD DESC:Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication Gene:YOR029W(YOR029W_d)|FD-Score:3.72|P-value:9.94E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR050C(YOR050C_d)|FD-Score:3.24|P-value:6.06E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable Gene:YOR228C(YOR228C)|FD-Score:-3.22|P-value:6.52E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YOR342C(YOR342C_p)|FD-Score:3.27|P-value:5.39E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication Gene:YPL260W(YPL260W_p)|FD-Score:-3.33|P-value:4.40E-4||SGD DESC:Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YPR147C(YPR147C_p)|FD-Score:-3.57|P-value:1.79E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS Gene:YPR153W(YPR153W)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Putative protein of unknown function Gene:YRA2(YKL214C)|FD-Score:4.21|P-value:1.27E-5||SGD DESC:Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus Gene:YTA6(YPL074W)|FD-Score:-3.74|P-value:9.04E-5||SGD DESC:Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress

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Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YER157W7.716.29E-153.10COG3Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YEL058W4.612.02E-60.11PCM1Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
YNL207W4.503.38E-60.43RIO2Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
YGR090W4.072.36E-50.02UTP22Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals
YHR088W4.052.56E-50.13RPF1Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
YDR088C3.924.38E-50.20SLU7RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YIL126W3.729.90E-50.04STH1ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YDR164C3.681.16E-40.24SEC1Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
YBR049C3.442.91E-40.04REB1RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication
YNL178W3.403.41E-40.16RPS3Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
YPR190C3.236.13E-40.01RPC82RNA polymerase III subunit C82
YDR510W3.226.40E-40.01SMT3Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
YOR004W3.216.65E-40.01UTP23Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
YBR247C3.206.97E-40.10ENP1Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
YOR046C3.109.80E-40.07DBP5Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YER087C-A_d10.201.48E-24YER087C-A_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase
YLL044W_d10.101.77E-24YLL044W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
YDR079C-A9.182.09E-20TFB5Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair
YKL025C9.085.48E-20PAN3Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
YKL032C7.996.73E-16IXR1Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YDL053C6.981.46E-12PBP4Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress
YGR037C6.701.08E-11ACB1Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
YCL036W6.351.06E-10GFD2Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication
YCR015C_p5.911.71E-9YCR015C_pPutative protein of unknown function; YCR015C is not an essential gene
YDR265W5.638.91E-9PEX10Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders
YBR259W_p5.452.52E-8YBR259W_pProtein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress
YLR131C5.364.12E-8ACE2Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
YJL115W5.238.53E-8ASF1Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YOR375C5.111.63E-7GDH1NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication
YMR216C5.101.68E-7SKY1SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1

GO enrichment analysis for SGTC_2407
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0841.20E-10SGTC_1603453-0671 289.7 μMChemDiv (Drug-like library)53222680.0833333
0.0741.32E-8SGTC_31259127534 49.5 μMChembridge (Drug-like library)16392350.108108
0.0664.16E-7SGTC_2410aloe-emodin-8-o-glycoside 46.3 μMTimTec (Pure natural product library)140774150.0866142mitochondrial processes
0.0656.87E-7SGTC_1568digitonin 820.0 nMTimTec (Pure natural product library)27350100.0745342sphingolipid biosynthesis & PDR1
0.0647.75E-7SGTC_1938st074717 56.4 μMTimTec (Natural product derivative library)172509790.0725806
0.0603.33E-6SGTC_28559016525 58.4 μMChembridge (Drug-like library)438114740.0672269
0.0596.48E-6SGTC_1836st055642 81.0 μMTimTec (Natural product derivative library)85710.07
0.0587.03E-6SGTC_7313966-0296 387.0 μMChemDiv (Drug-like library)6609560.092437
0.0588.75E-6SGTC_8950964-0006 13.7 μMChemDiv (Drug-like library)67388970.05
0.0579.94E-6SGTC_1948st076329 66.6 μMTimTec (Natural product derivative library)242084130.056
0.0561.67E-5SGTC_1932st074806 40.9 μMTimTec (Natural product derivative library)172512350.0869565
0.0561.77E-5SGTC_28287998861 71.4 μMChembridge (Drug-like library)29881880.0756303
0.0552.27E-5SGTC_5274476-4215 268.0 μMChemDiv (Drug-like library)44187540.105263PDR1
0.0543.49E-5SGTC_1846st056244 14.8 μMTimTec (Natural product derivative library)53931820.0862069
0.0535.28E-5SGTC_169k015-0017 16.0 μMChemDiv (Drug-like library)18400020.042735

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_220paclitaxel373.38 μM14666Miscellaneous853.906143.055414
SGTC_2419paclitaxel166.5 μM14666Miscellaneous853.906143.055414
SGTC_417st075190100 μM0.186441222757TimTec (Pure natural product library)376.488025.51213
SGTC_2649anisomycin9.56 μM0.1809526610309ICCB bioactive library235.278980.89324
SGTC_395anisomycin6.25 μM0.1809526610309ICCB bioactive library235.278980.89324
SGTC_1079idarubicin2.36 μM0.174603636362NIH Clinical Collection533.954821.026610DNA damage response
SGTC_1756st04155835.5 μM0.1654143955792TimTec (Natural product derivative library)564.649284.77928
SGTC_8810833-0569170 μM0.1651385418700ChemDiv (Drug-like library)306.315362.68414
SGTC_3260913710949.47 μM0.16504917478346Chembridge (Drug-like library)255.311683.1561260S ribosome export
SGTC_2653dihydrofissinolide100 μM0.1641796857746Microsource (Natural product library)514.607223.40808
SGTC_1931st07443857.1 μM0.1637932787313TimTec (Natural product derivative library)350.410983.91323
SGTC_7420kpi-0133140 μM0.1603772728852ChemDiv (Drug-like library)297.434483.98912ERG2