Deletion Strain | FD score | P-value | Gene | Gene Description |
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YPR198W | 7.32 | 1.22E-13 | SGE1 | Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations |
YLR448W | 6.86 | 3.57E-12 | RPL6B | Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication |
YBR191W | 6.75 | 7.39E-12 | RPL21A | Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication |
YPR032W | 5.97 | 1.17E-9 | SRO7 | Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication |
YCL030C | 5.94 | 1.43E-9 | HIS4 | Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis |
YGL228W | 5.90 | 1.86E-9 | SHE10 | Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest |
YLR084C | 5.48 | 2.16E-8 | RAX2 | N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p |
YCR047C | 5.43 | 2.81E-8 | BUD23 | Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern |
YIL039W | 5.30 | 5.69E-8 | TED1 | Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) |
YDR035W | 5.19 | 1.03E-7 | ARO3 | 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan |
YDR101C | 5.04 | 2.27E-7 | ARX1 | Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex |
YDR065W | 4.70 | 1.30E-6 | RRG1 | Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YKL170W | 4.67 | 1.51E-6 | MRPL38 | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress |
YMR189W | 4.66 | 1.60E-6 | GCV2 | P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm |
YKL211C | 4.57 | 2.49E-6 | TRP3 | Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p |