| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YIR021W | 9.69 | 1.62E-22 | MRS1 | Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA |
| YMR155W_p | 7.88 | 1.61E-15 | YMR155W_p | Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen |
| YJR034W | 7.16 | 3.98E-13 | PET191 | Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery |
| YMR292W | 7.12 | 5.51E-13 | GOT1 | Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition |
| YLR361C-A_p | 5.93 | 1.50E-9 | YLR361C-A_p | Putative protein of unknown function |
| YMR029C | 5.57 | 1.25E-8 | FAR8 | Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p |
| YDR248C_p | 5.40 | 3.30E-8 | YDR248C_p | Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1 |
| YLR251W | 5.25 | 7.79E-8 | SYM1 | Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 |
| YDR202C | 5.13 | 1.47E-7 | RAV2 | Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme |
| YDR219C | 4.99 | 3.02E-7 | MFB1 | Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding |
| YDR263C | 4.95 | 3.74E-7 | DIN7 | Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination |
| YDL100C | 4.76 | 9.61E-7 | GET3 | Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress |
| YMR279C | 4.74 | 1.05E-6 | YMR279C | Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication |
| YNL148C | 4.58 | 2.36E-6 | ALF1 | Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance |
| YLR108C_p | 4.43 | 4.66E-6 | YLR108C_p | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication |
