Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR123C | 5.92 | 1.61E-9 | INO2 | Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion |
YER038W-A_d | 5.53 | 1.61E-8 | YER038W-A_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria |
YPR044C_d | 5.10 | 1.68E-7 | OPI11_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO |
YHR138C_p | 4.93 | 4.22E-7 | YHR138C_p | Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress |
YGR027C | 4.87 | 5.64E-7 | RPS25A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication |
YMR234W | 4.80 | 7.98E-7 | RNH1 | Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) |
YCR086W | 4.33 | 7.60E-6 | CSM1 | Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation |
YIL124W | 4.30 | 8.41E-6 | AYR1 | NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones |
YNR075W | 4.25 | 1.06E-5 | COS10 | Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins |
YOL077W-A | 4.24 | 1.14E-5 | ATP19 | Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase |
YBR125C | 4.04 | 2.65E-5 | PTC4 | Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity |
YDR095C_d | 4.01 | 3.00E-5 | YDR095C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YLR268W | 4.00 | 3.14E-5 | SEC22 | R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog |
YIL025C_d | 3.98 | 3.51E-5 | YIL025C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YDR497C | 3.93 | 4.19E-5 | ITR1 | Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress |