Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YKL141W | 6.19 | 3.05E-10 | 1.11 | SDH3 | Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex |
YGL116W | 5.84 | 2.53E-9 | 1.11 | CDC20 | Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress |
YHR122W | 5.24 | 8.06E-8 | 1.11 | CIA2 | Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B |
YJL195C_d | 5.12 | 1.50E-7 | 1.11 | YJL195C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6 |
YDR407C | 4.02 | 2.93E-5 | 0.19 | TRS120 | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic |
YML092C | 3.82 | 6.56E-5 | 0.03 | PRE8 | Alpha 2 subunit of the 20S proteasome |
YKL012W | 3.79 | 7.42E-5 | 0.00 | PRP40 | U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex |
YPL028W | 3.79 | 7.54E-5 | 0.26 | ERG10 | Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis |
YDR413C_d | 3.53 | 2.07E-4 | 0.12 | YDR413C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing |
YPR085C | 3.41 | 3.21E-4 | 0.02 | ASA1 | Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 |
YDL008W | 3.39 | 3.48E-4 | 0.00 | APC11 | Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity |
YGL030W | 3.39 | 3.52E-4 | 0.09 | RPL30 | Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog |
YER126C | 3.30 | 4.84E-4 | 0.03 | NSA2 | Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA |
YKL028W | 3.27 | 5.45E-4 | 0.08 | TFA1 | TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening |
YKL112W | 3.19 | 7.13E-4 | 0.02 | ABF1 | DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair |