Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDR328C | 5.54 | 1.55E-8 | 0.83 | SKP1 | Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress |
YIL115C | 4.70 | 1.30E-6 | 0.50 | NUP159 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p) |
YKL144C | 4.20 | 1.31E-5 | 0.30 | RPC25 | RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p |
YDL043C | 3.91 | 4.71E-5 | 0.11 | PRP11 | Subunit of the SF3a splicing factor complex, required for spliceosome assembly |
YDL145C | 3.80 | 7.27E-5 | 0.08 | COP1 | Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway |
YMR240C | 3.72 | 9.89E-5 | 0.17 | CUS1 | Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p |
YBL014C | 3.55 | 1.94E-4 | 0.01 | RRN6 | Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p |
YDR160W | 3.54 | 2.00E-4 | 0.40 | SSY1 | Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes |
YOL005C | 3.14 | 8.31E-4 | 0.01 | RPB11 | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit |
YNL102W | 3.14 | 8.50E-4 | 0.12 | POL1 | Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis |
YCR035C | 3.01 | 0.00129 | 0.05 | RRP43 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress |
YDR235W | 2.96 | 0.00153 | 0.08 | PRP42 | U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats |
YDL163W_d | 2.88 | 0.00196 | 0.00 | YDL163W_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase |
YOR310C | 2.88 | 0.00197 | 0.07 | NOP58 | Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA |
YNL110C | 2.81 | 0.00247 | 0.10 | NOP15 | Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm |