Deletion Strain | FD score | P-value | Gene | Gene Description |
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YLR039C | 8.29 | 5.43E-17 | RIC1 | Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes |
YCR009C | 7.78 | 3.72E-15 | RVS161 | Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress |
YER090W | 7.50 | 3.30E-14 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
YOL143C | 6.90 | 2.61E-12 | RIB4 | Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin |
YHR022C-A_p | 6.38 | 9.12E-11 | YHR022C-A_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
YNL299W | 6.04 | 7.55E-10 | TRF5 | Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p |
YKL211C | 5.89 | 1.90E-9 | TRP3 | Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p |
YOR365C_p | 5.64 | 8.57E-9 | YOR365C_p | Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication |
YDR354W | 5.27 | 6.78E-8 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YKR019C | 4.92 | 4.29E-7 | IRS4 | EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication |
YCR044C | 4.77 | 9.40E-7 | PER1 | Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 |
YOR150W | 4.74 | 1.07E-6 | MRPL23 | Mitochondrial ribosomal protein of the large subunit |
YDR116C | 4.57 | 2.41E-6 | MRPL1 | Mitochondrial ribosomal protein of the large subunit |
YPR157W_p | 4.50 | 3.36E-6 | TDA6_p | Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele |
YGL100W | 4.40 | 5.51E-6 | SEH1 | Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 |