Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YLR243W_p | 4.74 | 1.05E-6 | 0.45 | GPN3_p | Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p |
YNL172W | 4.49 | 3.60E-6 | 0.45 | APC1 | Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress |
YGR115C_d | 4.28 | 9.32E-6 | 0.45 | YGR115C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C |
YHR036W | 4.25 | 1.08E-5 | 0.45 | BRL1 | Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export |
YDR145W | 3.80 | 7.33E-5 | 0.21 | TAF12 | Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A |
YDR021W | 3.58 | 1.69E-4 | 0.19 | FAL1 | Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases |
YDR365C | 3.40 | 3.41E-4 | 0.00 | ESF1 | Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels |
YOR063W | 3.39 | 3.44E-4 | 0.05 | RPL3 | Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus |
YOL040C | 3.34 | 4.15E-4 | 0.12 | RPS15 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 |
YOR244W | 3.22 | 6.30E-4 | 0.04 | ESA1 | Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy |
YKL088W | 3.19 | 7.13E-4 | 0.11 | CAB3 | Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC |
YJL015C_d | 3.08 | 0.00104 | 0.05 | YJL015C_d | Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W |
YDR267C | 3.02 | 0.00124 | 0.03 | CIA1 | Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein |
YDR434W | 2.99 | 0.00138 | 0.13 | GPI17 | Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog |
YGR265W_d | 2.86 | 0.00210 | 0.02 | YGR265W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase |