Deletion Strain | FD score | P-value | Gene | Gene Description |
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YLR131C | 6.51 | 3.65E-11 | ACE2 | Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication |
YMR202W | 6.13 | 4.28E-10 | ERG2 | C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis |
YBL042C | 5.87 | 2.18E-9 | FUI1 | High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress |
YJR118C | 5.83 | 2.69E-9 | ILM1 | Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth |
YIR023W | 5.82 | 2.93E-9 | DAL81 | Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism |
YBR069C | 5.71 | 5.77E-9 | TAT1 | Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress |
YBR013C_p | 5.69 | 6.46E-9 | YBR013C_p | Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein |
YLR096W | 5.67 | 7.22E-9 | KIN2 | Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p |
YJL120W_d | 5.49 | 2.04E-8 | YJL120W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO |
YDR336W_p | 5.08 | 1.86E-7 | YDR336W_p | Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene |
YHR001W-A | 4.59 | 2.26E-6 | QCR10 | Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain |
YHR022C-A_p | 4.42 | 4.84E-6 | YHR022C-A_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
YCR061W_p | 4.38 | 5.89E-6 | YCR061W_p | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation |
YOL038C-A_p | 4.16 | 1.61E-5 | YOL038C-A_p | Putative protein of unknown function; identified by SAGE analysis |
YPL091W | 4.10 | 2.11E-5 | GLR1 | Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress |