| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YMR071C | 4.81 | 7.61E-7 | TVP18 | Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments |
| YGR106C | 4.78 | 8.63E-7 | VOA1 | Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval |
| YLR096W | 4.74 | 1.08E-6 | KIN2 | Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p |
| YBR159W | 4.67 | 1.47E-6 | IFA38 | Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides |
| YOL143C | 4.50 | 3.46E-6 | RIB4 | Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin |
| YDL077C | 4.33 | 7.51E-6 | VAM6 | Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p |
| YGR129W | 4.32 | 7.74E-6 | SYF2 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest |
| YPR157W_p | 4.26 | 1.02E-5 | TDA6_p | Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele |
| YHR001W-A | 4.22 | 1.21E-5 | QCR10 | Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain |
| YLR454W_p | 4.04 | 2.65E-5 | FMP27_p | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| YBR106W | 4.00 | 3.22E-5 | PHO88 | Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations |
| YCR024C-A | 3.97 | 3.64E-5 | PMP1 | Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication |
| YLR236C_d | 3.87 | 5.49E-5 | YLR236C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YLL002W | 3.76 | 8.54E-5 | RTT109 | Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p |
| YBR016W | 3.70 | 1.06E-4 | YBR016W | Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication |
