derrusnin

3-(1,3-benzodioxol-5-yl)-4,5,7-trimethoxychromen-2-one

Part of coumarin class of compounds.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2492
Screen concentration 100.0 μM
Source Microsource (Natural product library)
PubChem CID 1715307
SMILES COC1=CC(=C2C(=C1)OC(=O)C(=C2OC)C3=CC4=C(C=C3)OCO4)OC
Standardized SMILES COC1=C(C(=O)Oc2cc(OC)cc(OC)c12)c3ccc4OCOc4c3
Molecular weight 356.3261
ALogP 2.8
H-bond donor count 0
H-bond acceptor count 7
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 2.92
% growth inhibition (Hom. pool) 7.31


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 1715307
Download HIP data (tab-delimited text)  (excel)
Gene:DCP1(YOL149W)|FD-Score:3.51|P-value:2.28E-4|Clearance:0.15||SGD DESC:Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress Gene:ERG9(YHR190W)|FD-Score:3.27|P-value:5.41E-4|Clearance:0.02||SGD DESC:Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway Gene:MTR10(YOR160W)|FD-Score:3.29|P-value:4.92E-4|Clearance:0.03||SGD DESC:Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:NSE3(YDR288W)|FD-Score:-3.86|P-value:5.65E-5|Clearance:0||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress Gene:PRP31(YGR091W)|FD-Score:4.13|P-value:1.82E-5|Clearance:0.09||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RPL30(YGL030W)|FD-Score:-3.45|P-value:2.77E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog Gene:RRP12(YPL012W)|FD-Score:3.16|P-value:7.87E-4|Clearance:0||SGD DESC:Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats Gene:SEC4(YFL005W)|FD-Score:3.35|P-value:4.03E-4|Clearance:0.06||SGD DESC:Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane Gene:SEN2(YLR105C)|FD-Score:3.16|P-value:7.91E-4|Clearance:0.11||SGD DESC:Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease Gene:SMD3(YLR147C)|FD-Score:4.04|P-value:2.71E-5|Clearance:0.53||SGD DESC:Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 Gene:SNP1(YIL061C)|FD-Score:-3.16|P-value:7.99E-4|Clearance:0||SGD DESC:Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress Gene:SPC3(YLR066W)|FD-Score:3.25|P-value:5.85E-4|Clearance:0.09||SGD DESC:Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 Gene:TRR1(YDR353W)|FD-Score:5.29|P-value:6.22E-8|Clearance:0.89||SGD DESC:Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication Gene:YDL196W(YDL196W_d)|FD-Score:5.38|P-value:3.75E-8|Clearance:0.89||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:YLR101C(YLR101C_d)|FD-Score:4.4|P-value:5.40E-6|Clearance:0.27||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W Gene:DCP1(YOL149W)|FD-Score:3.51|P-value:2.28E-4|Clearance:0.15||SGD DESC:Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress Gene:ERG9(YHR190W)|FD-Score:3.27|P-value:5.41E-4|Clearance:0.02||SGD DESC:Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway Gene:MTR10(YOR160W)|FD-Score:3.29|P-value:4.92E-4|Clearance:0.03||SGD DESC:Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:NSE3(YDR288W)|FD-Score:-3.86|P-value:5.65E-5|Clearance:0||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress Gene:PRP31(YGR091W)|FD-Score:4.13|P-value:1.82E-5|Clearance:0.09||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RPL30(YGL030W)|FD-Score:-3.45|P-value:2.77E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog Gene:RRP12(YPL012W)|FD-Score:3.16|P-value:7.87E-4|Clearance:0||SGD DESC:Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats Gene:SEC4(YFL005W)|FD-Score:3.35|P-value:4.03E-4|Clearance:0.06||SGD DESC:Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane Gene:SEN2(YLR105C)|FD-Score:3.16|P-value:7.91E-4|Clearance:0.11||SGD DESC:Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease Gene:SMD3(YLR147C)|FD-Score:4.04|P-value:2.71E-5|Clearance:0.53||SGD DESC:Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 Gene:SNP1(YIL061C)|FD-Score:-3.16|P-value:7.99E-4|Clearance:0||SGD DESC:Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress Gene:SPC3(YLR066W)|FD-Score:3.25|P-value:5.85E-4|Clearance:0.09||SGD DESC:Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 Gene:TRR1(YDR353W)|FD-Score:5.29|P-value:6.22E-8|Clearance:0.89||SGD DESC:Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication Gene:YDL196W(YDL196W_d)|FD-Score:5.38|P-value:3.75E-8|Clearance:0.89||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:YLR101C(YLR101C_d)|FD-Score:4.4|P-value:5.40E-6|Clearance:0.27||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 1715307
Download HOP data (tab-delimited text)  (excel)
Gene:APS2(YJR058C)|FD-Score:3.67|P-value:1.22E-4||SGD DESC:Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex Gene:ARO3(YDR035W)|FD-Score:4.8|P-value:7.84E-7||SGD DESC:3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan Gene:BNA2(YJR078W)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp Gene:CUP2(YGL166W)|FD-Score:3.32|P-value:4.52E-4||SGD DESC:Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication Gene:ECM5(YMR176W)|FD-Score:3.13|P-value:8.75E-4||SGD DESC:Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress Gene:END3(YNL084C)|FD-Score:-3.2|P-value:6.98E-4||SGD DESC:EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p Gene:FLO8(YER109C)|FD-Score:3.29|P-value:4.94E-4||SGD DESC:Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene Gene:HEF3(YNL014W)|FD-Score:-3.18|P-value:7.39E-4||SGD DESC:Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication Gene:IGD1(YFR017C)|FD-Score:3.86|P-value:5.57E-5||SGD DESC:Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication Gene:LYS5(YGL154C)|FD-Score:3.79|P-value:7.43E-5||SGD DESC:Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine Gene:MEC3(YLR288C)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 Gene:MIC17(YMR002W)|FD-Score:-3.15|P-value:8.28E-4||SGD DESC:Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress Gene:RPO41(YFL036W)|FD-Score:3.1|P-value:9.54E-4||SGD DESC:Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation Gene:SAS3(YBL052C)|FD-Score:3.86|P-value:5.57E-5||SGD DESC:Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal Gene:SHS1(YDL225W)|FD-Score:3.13|P-value:8.60E-4||SGD DESC:Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress Gene:SNO4(YMR322C_p)|FD-Score:3.97|P-value:3.60E-5||SGD DESC:Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation Gene:SPO7(YAL009W)|FD-Score:-4.07|P-value:2.35E-5||SGD DESC:Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation Gene:SPT2(YER161C)|FD-Score:-3.16|P-value:7.94E-4||SGD DESC:Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins Gene:TIS11(YLR136C)|FD-Score:3.37|P-value:3.74E-4||SGD DESC:mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:ULI1(YFR026C)|FD-Score:3.31|P-value:4.69E-4||SGD DESC:Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response Gene:YDR131C(YDR131C_p)|FD-Score:4.53|P-value:2.89E-6||SGD DESC:F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex Gene:YGL188C-A(YGL188C-A_p)|FD-Score:-3.42|P-value:3.13E-4||SGD DESC:Putative protein of unknown function Gene:YKL018C-A(YKL018C-A_p)|FD-Score:3.44|P-value:2.89E-4||SGD DESC:Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YLR053C(YLR053C_p)|FD-Score:3.12|P-value:9.06E-4||SGD DESC:Putative protein of unknown function Gene:YLR126C(YLR126C_p)|FD-Score:3.13|P-value:8.88E-4||SGD DESC:Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:YNL013C(YNL013C_d)|FD-Score:3.28|P-value:5.28E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W Gene:YNL046W(YNL046W_p)|FD-Score:3.83|P-value:6.41E-5||SGD DESC:Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:YTP1(YNL237W)|FD-Score:-4.23|P-value:1.19E-5||SGD DESC:Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins Gene:APS2(YJR058C)|FD-Score:3.67|P-value:1.22E-4||SGD DESC:Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex Gene:ARO3(YDR035W)|FD-Score:4.8|P-value:7.84E-7||SGD DESC:3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan Gene:BNA2(YJR078W)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp Gene:CUP2(YGL166W)|FD-Score:3.32|P-value:4.52E-4||SGD DESC:Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication Gene:ECM5(YMR176W)|FD-Score:3.13|P-value:8.75E-4||SGD DESC:Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress Gene:END3(YNL084C)|FD-Score:-3.2|P-value:6.98E-4||SGD DESC:EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p Gene:FLO8(YER109C)|FD-Score:3.29|P-value:4.94E-4||SGD DESC:Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene Gene:HEF3(YNL014W)|FD-Score:-3.18|P-value:7.39E-4||SGD DESC:Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication Gene:IGD1(YFR017C)|FD-Score:3.86|P-value:5.57E-5||SGD DESC:Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication Gene:LYS5(YGL154C)|FD-Score:3.79|P-value:7.43E-5||SGD DESC:Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine Gene:MEC3(YLR288C)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 Gene:MIC17(YMR002W)|FD-Score:-3.15|P-value:8.28E-4||SGD DESC:Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress Gene:RPO41(YFL036W)|FD-Score:3.1|P-value:9.54E-4||SGD DESC:Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation Gene:SAS3(YBL052C)|FD-Score:3.86|P-value:5.57E-5||SGD DESC:Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal Gene:SHS1(YDL225W)|FD-Score:3.13|P-value:8.60E-4||SGD DESC:Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress Gene:SNO4(YMR322C_p)|FD-Score:3.97|P-value:3.60E-5||SGD DESC:Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation Gene:SPO7(YAL009W)|FD-Score:-4.07|P-value:2.35E-5||SGD DESC:Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation Gene:SPT2(YER161C)|FD-Score:-3.16|P-value:7.94E-4||SGD DESC:Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins Gene:TIS11(YLR136C)|FD-Score:3.37|P-value:3.74E-4||SGD DESC:mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:ULI1(YFR026C)|FD-Score:3.31|P-value:4.69E-4||SGD DESC:Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response Gene:YDR131C(YDR131C_p)|FD-Score:4.53|P-value:2.89E-6||SGD DESC:F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex Gene:YGL188C-A(YGL188C-A_p)|FD-Score:-3.42|P-value:3.13E-4||SGD DESC:Putative protein of unknown function Gene:YKL018C-A(YKL018C-A_p)|FD-Score:3.44|P-value:2.89E-4||SGD DESC:Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YLR053C(YLR053C_p)|FD-Score:3.12|P-value:9.06E-4||SGD DESC:Putative protein of unknown function Gene:YLR126C(YLR126C_p)|FD-Score:3.13|P-value:8.88E-4||SGD DESC:Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:YNL013C(YNL013C_d)|FD-Score:3.28|P-value:5.28E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W Gene:YNL046W(YNL046W_p)|FD-Score:3.83|P-value:6.41E-5||SGD DESC:Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:YTP1(YNL237W)|FD-Score:-4.23|P-value:1.19E-5||SGD DESC:Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDL196W_d5.383.75E-80.89YDL196W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YDR353W5.296.22E-80.89TRR1Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication
YLR101C_d4.405.40E-60.27YLR101C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
YGR091W4.131.82E-50.09PRP31Splicing factor, component of the U4/U6-U5 snRNP complex
YLR147C4.042.71E-50.53SMD3Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
YOL149W3.512.28E-40.15DCP1Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
YFL005W3.354.03E-40.06SEC4Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
YOR160W3.294.92E-40.03MTR10Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
YHR190W3.275.41E-40.02ERG9Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
YLR066W3.255.85E-40.09SPC3Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
YPL012W3.167.87E-40.00RRP12Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
YLR105C3.167.91E-40.11SEN2Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
YLR115W3.050.001140.00CFT2Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.
YDR376W3.050.001160.08ARH1Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
YMR131C2.970.001510.04RRB1Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR035W4.807.84E-7ARO33-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
YDR131C_p4.532.89E-6YDR131C_pF-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
YMR322C_p3.973.60E-5SNO4_pPossible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
YBL052C3.865.57E-5SAS3Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal
YFR017C3.865.57E-5IGD1Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
YNL046W_p3.836.41E-5YNL046W_pPutative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YGL154C3.797.43E-5LYS5Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
YJR078W3.681.17E-4BNA2Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp
YJR058C3.671.22E-4APS2Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
YLR288C3.472.60E-4MEC3DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
YKL018C-A_p3.442.89E-4YKL018C-A_pPutative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR136C3.373.74E-4TIS11mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
YGL166W3.324.52E-4CUP2Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
YFR026C3.314.69E-4ULI1Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
YER109C3.294.94E-4FLO8Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene

GO enrichment analysis for SGTC_2492
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2441.50E-80SGTC_2490carminic acid 95.4 μMTimTec (Pure natural product library)147490.0909091
0.1865.32E-47SGTC_2493resveratrol 26.1 μMMicrosource (Natural product library)62554620.169492
0.1632.09E-36SGTC_2491paeonol 100.0 μMMicrosource (Natural product library)110920.186441
0.1031.87E-15SGTC_252miconazole 1.3 nMMiscellaneous41890.0617284ergosterol depletion effects on membrane
0.0961.70E-13SGTC_2733amorolfine 100.0 μMMiscellaneous542600.0779221plasma membrane duress
0.0961.76E-13SGTC_262fenpropimorph 62.5 μMMiscellaneous916950.0810811ergosterol depletion effects on membrane
0.0899.44E-12SGTC_5154092-1064 102.0 μMChemDiv (Drug-like library)7173530.0746269plasma membrane duress
0.0881.20E-11SGTC_29309013230 14.9 μMChembridge (Drug-like library)29958570.0649351heme biosynthesis & mitochondrial translocase
0.0791.05E-9SGTC_13471493-0251 600.0 nMChemDiv (Drug-like library)39863780.116667mitochondrial response to ROS
0.0741.27E-8SGTC_1975st070967 30.8 μMTimTec (Natural product derivative library)2613910.15625
0.0732.01E-8SGTC_31419094609 49.5 μMChembridge (Drug-like library)252363090.0609756iron homeostasis
0.0715.59E-8SGTC_1801486-1293 102.8 μMChemDiv (Drug-like library)41405360.0697674
0.0707.59E-8SGTC_1072oxiconazole 14.9 nMNIH Clinical Collection473160.0595238ergosterol depletion effects on membrane
0.0691.21E-7SGTC_29489070189 9.4 μMChembridge (Drug-like library)64736360.0595238plasma membrane duress
0.0681.60E-7SGTC_7131488-1073 324.0 μMChemDiv (Drug-like library)33125420.075ERG2

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2557derrustone83.84 μM0.581818629853Microsource (Natural product library)326.300162.60106
SGTC_1593justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one54.9 μM0.442623442882TimTec (Pure natural product library)364.348143.60106redox potentiating
SGTC_2550chrysin dimethyl ether71.87 μM0.42105388881Microsource (Natural product library)282.290663.10304
SGTC_1548st06146890.8 μM0.415094390799TimTec (Pure natural product library)220.221282.31304
SGTC_1929genistein trimethyl ether50.5 μM0.403509136420TimTec (Natural product derivative library)312.316642.81705
SGTC_25903,4',5',6',7'-pentamethoxyflavone100 μM0.383333521171Microsource (Natural product library)372.36862.7580760S ribosome export
SGTC_2556citropten84.59 μM0.3518522775Microsource (Natural product library)206.19471.86604
SGTC_2636apigenin dimethyl ether100 μM0.355281601Microsource (Natural product library)298.290062.86115
SGTC_2595hexamethylquercetagetin100 μM0.33871386331Microsource (Natural product library)402.394582.74208
SGTC_1867st05737264 μM0.322034688837TimTec (Natural product derivative library)312.316643.08705