Deletion Strain | FD score | P-value | Gene | Gene Description |
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YGL031C | 5.85 | 2.53E-9 | RPL24A | Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication |
YPR197C_d | 5.38 | 3.75E-8 | YPR197C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YOR114W_p | 5.19 | 1.07E-7 | YOR114W_p | Putative protein of unknown function; null mutant is viable |
YOL145C | 4.80 | 7.97E-7 | CTR9 | Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats |
YGL054C | 4.66 | 1.61E-6 | ERV14 | COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication |
YJR105W | 4.58 | 2.29E-6 | ADO1 | Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle |
YCR098C | 4.51 | 3.20E-6 | GIT1 | Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability |
YMR205C | 4.43 | 4.74E-6 | PFK2 | Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes |
YKR073C_d | 4.32 | 7.86E-6 | YKR073C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YOR147W | 4.15 | 1.64E-5 | MDM32 | Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 |
YLR065C | 4.14 | 1.73E-5 | ENV10 | Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene |
YOL029C_p | 4.08 | 2.26E-5 | YOL029C_p | Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens |
YCR034W | 4.03 | 2.84E-5 | FEN1 | Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication |
YHR098C | 3.96 | 3.74E-5 | SFB3 | Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p |
YDR024W_d | 3.94 | 4.16E-5 | FYV1_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin |