Deletion Strain | FD score | P-value | Gene | Gene Description |
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YJR009C | 9.61 | 3.50E-22 | TDH2 | Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; TDH2 has a paralog, TDH3, that arose from the whole genome duplication |
YPL158C | 6.06 | 6.60E-10 | AIM44 | Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress |
YDR035W | 5.27 | 6.68E-8 | ARO3 | 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan |
YLR295C | 4.81 | 7.63E-7 | ATP14 | Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress |
YNL190W_p | 4.59 | 2.26E-6 | YNL190W_p | Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site |
YMR230W | 4.51 | 3.20E-6 | RPS10B | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication |
YCL001W-A_p | 4.45 | 4.36E-6 | YCL001W-A_p | Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III |
YKL068W-A_p | 4.15 | 1.64E-5 | YKL068W-A_p | Putative protein of unknown function; identified by homology to Ashbya gossypii |
YML062C | 4.10 | 2.10E-5 | MFT1 | Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance |
YER141W | 3.97 | 3.64E-5 | COX15 | Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase |
YNL283C | 3.82 | 6.67E-5 | WSC2 | Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response |
YGL136C | 3.75 | 8.97E-5 | MRM2 | Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ |
YKR020W | 3.75 | 9.00E-5 | VPS51 | Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p |
YLR288C | 3.72 | 9.82E-5 | MEC3 | DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 |
YBR009C | 3.58 | 1.72E-4 | HHF1 | Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity |