Deletion Strain | FD score | P-value | Gene | Gene Description |
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YER162C | 10.80 | 1.17E-27 | RAD4 | Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins |
YLR403W | 8.12 | 2.41E-16 | SFP1 | Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion |
YLR032W | 7.58 | 1.79E-14 | RAD5 | DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress |
YFL016C | 7.18 | 3.59E-13 | MDJ1 | Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones |
YBR007C_p | 6.46 | 5.34E-11 | DSF2_p | Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress |
YMR195W | 6.38 | 8.86E-11 | ICY1 | Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation |
YMR179W | 5.87 | 2.17E-9 | SPT21 | Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress |
YOR369C | 5.77 | 4.00E-9 | RPS12 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog |
YHL004W | 4.86 | 5.82E-7 | MRP4 | Mitochondrial ribosomal protein of the small subunit |
YLR289W | 4.78 | 8.96E-7 | GUF1 | Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor |
YDR369C | 4.50 | 3.35E-6 | XRS2 | Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling |
YPR156C | 4.48 | 3.69E-6 | TPO3 | Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication |
YMR085W_p | 4.35 | 6.74E-6 | YMR085W_p | Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 |
YDL194W | 4.33 | 7.41E-6 | SNF3 | Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication |
YPL118W | 4.24 | 1.13E-5 | MRP51 | Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences |