Deletion Strain | FD score | P-value | Gene | Gene Description |
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YHR129C | 7.10 | 6.44E-13 | ARP1 | Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin |
YGL013C | 6.85 | 3.65E-12 | PDR1 | Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication |
YPL193W | 5.33 | 5.05E-8 | RSA1 | Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly |
YPR018W | 5.23 | 8.61E-8 | RLF2 | Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription |
YDR035W | 5.22 | 8.86E-8 | ARO3 | 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan |
YBR095C | 5.15 | 1.34E-7 | RXT2 | Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth |
YNL231C | 5.04 | 2.32E-7 | PDR16 | Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress |
YHR146W | 4.83 | 6.88E-7 | CRP1 | Protein that binds to cruciform DNA structures |
YNL205C_d | 4.80 | 7.99E-7 | YNL205C_d | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YCR081W | 4.72 | 1.16E-6 | SRB8 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression |
YBR286W | 4.62 | 1.96E-6 | APE3 | Vacuolar aminopeptidase Y, processed to mature form by Prb1p |
YMR294W-A_d | 4.56 | 2.51E-6 | YMR294W-A_d | Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents |
YIL008W | 4.35 | 6.75E-6 | URM1 | Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response |
YBR061C | 4.28 | 9.37E-6 | TRM7 | 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively |
YPL053C | 4.27 | 9.66E-6 | KTR6 | Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication |