Deletion Strain | FD score | P-value | Gene | Gene Description |
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YEL027W | 6.04 | 7.63E-10 | VMA3 | Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis |
YPR172W_p | 5.05 | 2.21E-7 | YPR172W_p | Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication |
YBR058C-A | 5.02 | 2.52E-7 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YDR014W | 4.90 | 4.86E-7 | RAD61 | Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin |
YPL216W_p | 4.88 | 5.33E-7 | YPL216W_p | Putative protein of unknown function; YPL216W is not an essential gene |
YDR035W | 4.85 | 6.14E-7 | ARO3 | 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan |
YER166W | 4.74 | 1.06E-6 | DNF1 | Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase |
YKL073W | 4.57 | 2.49E-6 | LHS1 | Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway |
YKL016C | 4.56 | 2.50E-6 | ATP7 | Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis |
YER107C | 4.43 | 4.76E-6 | GLE2 | RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 |
YHR100C | 4.40 | 5.34E-6 | GEP4 | Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT |
YOR357C | 4.37 | 6.33E-6 | SNX3 | Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p |
YGR078C | 4.36 | 6.65E-6 | PAC10 | Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding |
YOR120W | 4.19 | 1.40E-5 | GCY1 | Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication |
YFR040W | 4.14 | 1.70E-5 | SAP155 | Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress |