Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKL155C | 8.73 | 1.23E-18 | RSM22 | Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase |
YKR072C | 6.47 | 4.88E-11 | SIS2 | Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis |
YOR343C_d | 4.91 | 4.46E-7 | YOR343C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YLR431C | 4.72 | 1.18E-6 | ATG23 | Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p |
YKR073C_d | 4.64 | 1.75E-6 | YKR073C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YMR319C | 4.44 | 4.47E-6 | FET4 | Low-affinity Fe(II) transporter of the plasma membrane |
YGL186C | 4.21 | 1.28E-5 | TPN1 | Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p |
YHR006W | 4.20 | 1.32E-5 | STP2 | Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication |
YEL011W | 4.16 | 1.58E-5 | GLC3 | Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
YMR066W | 4.10 | 2.02E-5 | SOV1 | Mitochondrial protein of unknown function |
YOR188W | 4.05 | 2.51E-5 | MSB1 | Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress |
YGL100W | 3.93 | 4.31E-5 | SEH1 | Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 |
YCL075W | 3.80 | 7.16E-5 | YCL075W | Pseudogene: encodes fragment of Ty Pol protein |
YDR049W | 3.80 | 7.23E-5 | VMS1 | Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans |
YBR273C | 3.75 | 9.02E-5 | UBX7 | UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication |