| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YIL008W | 6.92 | 2.28E-12 | URM1 | Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response |
| YBR201W | 6.75 | 7.31E-12 | DER1 | Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p |
| YPL072W | 6.49 | 4.22E-11 | UBP16 | Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria |
| YDR144C | 6.18 | 3.23E-10 | MKC7 | GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p |
| YLR403W | 5.70 | 5.90E-9 | SFP1 | Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion |
| YLR200W | 5.44 | 2.67E-8 | YKE2 | Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin |
| YGL089C | 5.32 | 5.26E-8 | MF(ALPHA)2 | Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 |
| YML055W | 5.30 | 5.80E-8 | SPC2 | Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 |
| YOL079W_d | 5.23 | 8.28E-8 | YOL079W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YLL024C | 4.90 | 4.85E-7 | SSA2 | ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes |
| YLR372W | 4.82 | 7.28E-7 | SUR4 | Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis |
| YIL161W_p | 4.74 | 1.05E-6 | YIL161W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene |
| YLR224W_p | 4.62 | 1.92E-6 | YLR224W_p | F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene |
| YKR070W_p | 4.56 | 2.61E-6 | YKR070W_p | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| YOR320C | 4.42 | 4.88E-6 | GNT1 | N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus |
