Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR225W | 13.30 | 1.12E-40 | HTA1 | Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p |
YNL248C | 9.10 | 4.34E-20 | RPA49 | RNA polymerase I subunit A49 |
YMR311C | 7.42 | 5.80E-14 | GLC8 | Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress |
YER129W | 6.93 | 2.05E-12 | SAK1 | Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome |
YHL031C | 6.22 | 2.44E-10 | GOS1 | v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 |
YPL049C | 5.91 | 1.70E-9 | DIG1 | MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p |
YHR179W | 5.90 | 1.78E-9 | OYE2 | Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress |
YLR412C-A_p | 5.87 | 2.12E-9 | YLR412C-A_p | Putative protein of unknown function |
YCR023C | 5.67 | 7.10E-9 | YCR023C | Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene |
YBL039C | 5.51 | 1.75E-8 | URA7 | Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication |
YMR194W | 5.08 | 1.93E-7 | RPL36A | Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication |
YJL148W | 4.75 | 1.01E-6 | RPA34 | RNA polymerase I subunit A34.5 |
YLR148W | 4.63 | 1.81E-6 | PEP3 | Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis |
YOR295W | 4.56 | 2.60E-6 | UAF30 | Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication |
YBR095C | 4.48 | 3.74E-6 | RXT2 | Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth |