3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin

(3-ethoxyphenyl)-(2,3,4-trihydroxyphenyl)methanone

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2548
Screen concentration 19.9 μM
Source Microsource (Natural product library)
PubChem CID 4000243
SMILES CCOC1=CC=CC(=C1)C(=O)C2=C(C(=C(C=C2)O)O)O
Standardized SMILES CCOc1cccc(c1)C(=O)c2ccc(O)c(O)c2O
Molecular weight 274.2687
ALogP 2.84
H-bond donor count 3
H-bond acceptor count 5
Response signature redox potentiating

Pool Growth Kinetics
% growth inhibition (Het. pool) 16.43
% growth inhibition (Hom. pool) 4.99


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4000243
Download HIP data (tab-delimited text)  (excel)
Gene:GDI1(YER136W)|FD-Score:3.29|P-value:5.07E-4|Clearance:0.35||SGD DESC:GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins Gene:IRR1(YIL026C)|FD-Score:4.05|P-value:2.55E-5|Clearance:0.76||SGD DESC:Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability Gene:NFS1(YCL017C)|FD-Score:5.38|P-value:3.78E-8|Clearance:1.33||SGD DESC:Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria Gene:YGL069C(YGL069C_d)|FD-Score:-3.36|P-value:3.95E-4|Clearance:0||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance Gene:GDI1(YER136W)|FD-Score:3.29|P-value:5.07E-4|Clearance:0.35||SGD DESC:GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins Gene:IRR1(YIL026C)|FD-Score:4.05|P-value:2.55E-5|Clearance:0.76||SGD DESC:Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability Gene:NFS1(YCL017C)|FD-Score:5.38|P-value:3.78E-8|Clearance:1.33||SGD DESC:Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria Gene:YGL069C(YGL069C_d)|FD-Score:-3.36|P-value:3.95E-4|Clearance:0||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4000243
Download HOP data (tab-delimited text)  (excel)
Gene:AFT1(YGL071W)|FD-Score:3.38|P-value:3.62E-4||SGD DESC:Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:AIM43(YPL099C)|FD-Score:4.68|P-value:1.43E-6||SGD DESC:Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:APD1(YBR151W)|FD-Score:7.62|P-value:1.24E-14||SGD DESC:Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus Gene:APP1(YNL094W)|FD-Score:3.46|P-value:2.74E-4||SGD DESC:Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway Gene:BTS1(YPL069C)|FD-Score:-3.18|P-value:7.26E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CBR1(YIL043C)|FD-Score:-3.1|P-value:9.68E-4||SGD DESC:Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia Gene:CCS1(YMR038C)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress Gene:DSS1(YMR287C)|FD-Score:-4.69|P-value:1.35E-6||SGD DESC:3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs Gene:EAP1(YKL204W)|FD-Score:-3.27|P-value:5.33E-4||SGD DESC:eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade Gene:GYP1(YOR070C)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HHF1(YBR009C)|FD-Score:-3.12|P-value:9.07E-4||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:IMO32(YGR031W)|FD-Score:3.73|P-value:9.68E-5||SGD DESC:Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 Gene:INO4(YOL108C)|FD-Score:4.3|P-value:8.43E-6||SGD DESC:Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain Gene:MAC1(YMR021C)|FD-Score:6.1|P-value:5.41E-10||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MDM38(YOL027C)|FD-Score:3.16|P-value:8.00E-4||SGD DESC:Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome Gene:MET3(YJR010W)|FD-Score:3.43|P-value:2.97E-4||SGD DESC:ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism Gene:MRP7(YNL005C)|FD-Score:-3.45|P-value:2.82E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL23(YOR150W)|FD-Score:-3.2|P-value:6.79E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NGG1(YDR176W)|FD-Score:4.43|P-value:4.69E-6||SGD DESC:Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex Gene:PDH1(YPR002W)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PPA2(YMR267W)|FD-Score:-3.41|P-value:3.25E-4||SGD DESC:Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate Gene:PRO2(YOR323C)|FD-Score:4.01|P-value:3.08E-5||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:RIM1(YCR028C-A)|FD-Score:-3.27|P-value:5.31E-4||SGD DESC:Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication Gene:RPL33B(YOR234C)|FD-Score:-3.31|P-value:4.74E-4||SGD DESC:Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication Gene:RPL39(YJL189W)|FD-Score:-3.41|P-value:3.20E-4||SGD DESC:Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog Gene:RPS1B(YML063W)|FD-Score:-3.64|P-value:1.36E-4||SGD DESC:Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication Gene:SAC1(YKL212W)|FD-Score:-3.38|P-value:3.61E-4||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SNQ2(YDR011W)|FD-Score:4.03|P-value:2.80E-5||SGD DESC:Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species Gene:SOD1(YJR104C)|FD-Score:4.68|P-value:1.41E-6||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:SSQ1(YLR369W)|FD-Score:5.31|P-value:5.42E-8||SGD DESC:Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia Gene:TAD1(YGL243W)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala Gene:TPO5(YKL174C)|FD-Score:3.79|P-value:7.58E-5||SGD DESC:Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles Gene:VPS25(YJR102C)|FD-Score:3.89|P-value:4.94E-5||SGD DESC:Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome Gene:YDR415C(YDR415C_p)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Putative aminopeptidase Gene:YJL171C(YJL171C)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress Gene:YLR413W(YLR413W_p)|FD-Score:3.49|P-value:2.38E-4||SGD DESC:Putative protein of unknown function; YLR413W is not an essential gene Gene:YOR019W(YOR019W)|FD-Score:3.28|P-value:5.23E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments Gene:AFT1(YGL071W)|FD-Score:3.38|P-value:3.62E-4||SGD DESC:Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:AIM43(YPL099C)|FD-Score:4.68|P-value:1.43E-6||SGD DESC:Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:APD1(YBR151W)|FD-Score:7.62|P-value:1.24E-14||SGD DESC:Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus Gene:APP1(YNL094W)|FD-Score:3.46|P-value:2.74E-4||SGD DESC:Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway Gene:BTS1(YPL069C)|FD-Score:-3.18|P-value:7.26E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CBR1(YIL043C)|FD-Score:-3.1|P-value:9.68E-4||SGD DESC:Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia Gene:CCS1(YMR038C)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress Gene:DSS1(YMR287C)|FD-Score:-4.69|P-value:1.35E-6||SGD DESC:3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs Gene:EAP1(YKL204W)|FD-Score:-3.27|P-value:5.33E-4||SGD DESC:eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade Gene:GYP1(YOR070C)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HHF1(YBR009C)|FD-Score:-3.12|P-value:9.07E-4||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:IMO32(YGR031W)|FD-Score:3.73|P-value:9.68E-5||SGD DESC:Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 Gene:INO4(YOL108C)|FD-Score:4.3|P-value:8.43E-6||SGD DESC:Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain Gene:MAC1(YMR021C)|FD-Score:6.1|P-value:5.41E-10||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MDM38(YOL027C)|FD-Score:3.16|P-value:8.00E-4||SGD DESC:Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome Gene:MET3(YJR010W)|FD-Score:3.43|P-value:2.97E-4||SGD DESC:ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism Gene:MRP7(YNL005C)|FD-Score:-3.45|P-value:2.82E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL23(YOR150W)|FD-Score:-3.2|P-value:6.79E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NGG1(YDR176W)|FD-Score:4.43|P-value:4.69E-6||SGD DESC:Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex Gene:PDH1(YPR002W)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PPA2(YMR267W)|FD-Score:-3.41|P-value:3.25E-4||SGD DESC:Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate Gene:PRO2(YOR323C)|FD-Score:4.01|P-value:3.08E-5||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:RIM1(YCR028C-A)|FD-Score:-3.27|P-value:5.31E-4||SGD DESC:Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication Gene:RPL33B(YOR234C)|FD-Score:-3.31|P-value:4.74E-4||SGD DESC:Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication Gene:RPL39(YJL189W)|FD-Score:-3.41|P-value:3.20E-4||SGD DESC:Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog Gene:RPS1B(YML063W)|FD-Score:-3.64|P-value:1.36E-4||SGD DESC:Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication Gene:SAC1(YKL212W)|FD-Score:-3.38|P-value:3.61E-4||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SNQ2(YDR011W)|FD-Score:4.03|P-value:2.80E-5||SGD DESC:Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species Gene:SOD1(YJR104C)|FD-Score:4.68|P-value:1.41E-6||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:SSQ1(YLR369W)|FD-Score:5.31|P-value:5.42E-8||SGD DESC:Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia Gene:TAD1(YGL243W)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala Gene:TPO5(YKL174C)|FD-Score:3.79|P-value:7.58E-5||SGD DESC:Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles Gene:VPS25(YJR102C)|FD-Score:3.89|P-value:4.94E-5||SGD DESC:Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome Gene:YDR415C(YDR415C_p)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Putative aminopeptidase Gene:YJL171C(YJL171C)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress Gene:YLR413W(YLR413W_p)|FD-Score:3.49|P-value:2.38E-4||SGD DESC:Putative protein of unknown function; YLR413W is not an essential gene Gene:YOR019W(YOR019W)|FD-Score:3.28|P-value:5.23E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YCL017C5.383.78E-81.33NFS1Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
YIL026C4.052.55E-50.76IRR1Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
YER136W3.295.07E-40.35GDI1GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YDR397C2.930.001680.14NCB2Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
YNL260C_p2.790.002620.01LTO1_pEssential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
YFL009W2.780.002740.04CDC4F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
YBR190W_d2.740.003100.06YBR190W_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
YJR013W2.670.003770.18GPI14Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
YKL059C2.490.006390.18MPE1Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
YGL091C2.310.010500.06NBP35Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
YOR157C2.250.012300.02PUP1Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
YNR038W2.230.012800.06DBP6Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
YAL038W2.170.015000.01CDC19Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
YBR002C2.160.015300.00RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YLR276C2.160.015400.00DBP9DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YBR151W7.621.24E-14APD1Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
YMR021C6.105.41E-10MAC1Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YLR369W5.315.42E-8SSQ1Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia
YJR104C4.681.41E-6SOD1Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
YPL099C4.681.43E-6AIM43Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
YDR176W4.434.69E-6NGG1Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
YOL108C4.308.43E-6INO4Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
YDR011W4.032.80E-5SNQ2Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species
YOR323C4.013.08E-5PRO2Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
YJR102C3.894.94E-5VPS25Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
YKL174C3.797.58E-5TPO5Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
YGR031W3.739.68E-5IMO32Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1
YMR038C3.631.43E-4CCS1Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
YOR070C3.571.78E-4GYP1Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
YDR415C_p3.541.99E-4YDR415C_pPutative aminopeptidase

GO enrichment analysis for SGTC_2548
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1799.59E-44SGTC_102gallobenzophenone 83.6 μMChemDiv (Drug-like library)708370.55redox potentiating
0.1693.30E-39SGTC_26092,3,4-trihydroxy-4'-ethoxybenzophenone 70.0 μMMicrosource (Natural product library)67087390.707317redox potentiating
0.1528.28E-32SGTC_1563474-0145 5.6 μMChemDiv (Drug-like library)22654710.162162endomembrane recycling
0.1431.94E-28SGTC_21715739187 198.1 μMChembridge (Fragment library)22627610.117647copper-dependent oxidative stress
0.1381.46E-26SGTC_10004048-0884 8.7 μMChemDiv (Drug-like library)130400880.166667copper-dependent oxidative stress
0.1309.36E-24SGTC_21966573537 42.7 μMChembridge (Fragment library)29030870.0983607copper-dependent oxidative stress
0.1292.97E-23SGTC_10014048-4355 44.4 μMChemDiv (Drug-like library)218242330.0810811copper-dependent oxidative stress
0.1293.11E-23SGTC_8590439-0102 54.6 μMChemDiv (Drug-like library)6101430.0983607redox potentiating
0.1271.03E-22SGTC_6704204-0025 119.0 μMChemDiv (Drug-like library)7190390.203125copper-dependent oxidative stress
0.1254.56E-22SGTC_1569carminic acid 40.6 μMTimTec (Pure natural product library)147490.155844
0.1224.57E-21SGTC_11740739-0097 51.1 μMChemDiv (Drug-like library)7284470.321429redox potentiating
0.1219.07E-21SGTC_2682pyrogallin 40.0 μMMicrosource (Natural product library)8227980.185185copper-dependent oxidative stress
0.1201.72E-20SGTC_1763st044482 94.5 μMTimTec (Natural product derivative library)885050.103448copper-dependent oxidative stress
0.1102.33E-17SGTC_7543474-0146 171.0 μMChemDiv (Drug-like library)247620780.141176copper-dependent oxidative stress
0.1081.07E-16SGTC_25272',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.6 μMMicrosource (Natural product library)67289400.520833

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_26092,3,4-trihydroxy-4'-ethoxybenzophenone70 μM0.7073176708739Microsource (Natural product library)274.268662.8435redox potentiating
SGTC_102gallobenzophenone83.62 μM0.5570837ChemDiv (Drug-like library)230.21612.50834redox potentiating
SGTC_25272',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone63.64 μM0.5208336728940Microsource (Natural product library)288.295243.06625
SGTC_2931901467455.67 μM0.5098042996810Chembridge (Drug-like library)326.174624.03323
SGTC_3184910875849.47 μM0.44898902885Chembridge (Drug-like library)241.28512.94712
SGTC_3188911078949.47 μM0.415094849217Chembridge (Drug-like library)275.730163.61112iron homeostasis
SGTC_3187910939449.47 μM0.36363617098090Chembridge (Drug-like library)247.312822.913Golgi
SGTC_3207911416349.47 μM0.363636849233Chembridge (Drug-like library)269.338263.43812
SGTC_2477596768625.23 μM0.358491776118Miscellaneous270.279962.89614
SGTC_720744-0168198.39 μM0.352941677577ChemDiv (Drug-like library)244.242682.58524RPP1 & pyrimidine depletion