Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YLR229C | 5.07 | 1.99E-7 | 1.13 | CDC42 | Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins |
YOR250C | 3.94 | 4.00E-5 | 0.49 | CLP1 | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation |
YLR314C | 3.46 | 2.72E-4 | 0.49 | CDC3 | Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells |
YGR251W | 2.97 | 0.00148 | 0.27 | NOP19 | Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes |
YLR026C | 2.70 | 0.00346 | 0.11 | SED5 | cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins |
YKL089W | 2.59 | 0.00480 | 0.07 | MIF2 | Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3 |
YER012W | 2.52 | 0.00590 | 0.01 | PRE1 | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle |
YNL240C | 2.51 | 0.00607 | 0.00 | NAR1 | Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf |
YLR223C | 2.51 | 0.00609 | 0.11 | IFH1 | Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing |
YKL122C | 2.40 | 0.00828 | 0.03 | SRP21 | Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm |
YKL189W | 2.37 | 0.00894 | 0.01 | HYM1 | Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response |
YOL135C | 2.35 | 0.00930 | 0.05 | MED7 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation |
YER023W | 2.30 | 0.01070 | 0.03 | PRO3 | Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis |
YAL038W | 2.28 | 0.01140 | 0.02 | CDC19 | Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication |
YBR089W_d | 2.26 | 0.01190 | 0.09 | YBR089W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30 |