Deletion Strain | FD score | P-value | Gene | Gene Description |
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YMR089C | 7.69 | 7.09E-15 | YTA12 | Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes |
YCR003W | 6.43 | 6.41E-11 | MRPL32 | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
YPL095C | 6.36 | 1.04E-10 | EEB1 | Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication |
YDL198C | 6.32 | 1.29E-10 | GGC1 | Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family |
YJL164C | 5.86 | 2.26E-9 | TPK1 | cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication |
YNL081C | 5.65 | 7.93E-9 | SWS2 | Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency |
YGR068C | 5.59 | 1.13E-8 | ART5 | Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane |
YBR245C | 5.43 | 2.90E-8 | ISW1 | ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions |
YHR203C | 5.39 | 3.46E-8 | RPS4B | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication |
YBR081C | 5.31 | 5.56E-8 | SPT7 | Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex |
YGL153W | 5.29 | 6.09E-8 | PEX14 | Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p |
YDR213W | 4.93 | 4.06E-7 | UPC2 | Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication |
YCR065W | 4.85 | 6.13E-7 | HCM1 | Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role |
YCR046C | 4.81 | 7.59E-7 | IMG1 | Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome |
YPL097W | 4.63 | 1.83E-6 | MSY1 | Mitochondrial tyrosyl-tRNA synthetase |