Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YIL129C | 15.50 | 1.57E-54 | 2.23 | TAO3 | Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p |
YHR036W | 13.60 | 1.69E-42 | 2.23 | BRL1 | Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export |
YLR208W | 13.10 | 1.95E-39 | 2.23 | SEC13 | Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress |
YDL195W | 13.00 | 1.15E-38 | 2.23 | SEC31 | Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance |
YKL028W | 12.30 | 2.65E-35 | 2.23 | TFA1 | TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening |
YJL081C | 11.60 | 3.52E-31 | 2.23 | ARP4 | Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes |
YJL054W | 11.50 | 8.59E-31 | 2.23 | TIM54 | Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane |
YDL147W | 9.25 | 1.16E-20 | 1.13 | RPN5 | Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein |
YFL039C | 8.12 | 2.33E-16 | 0.20 | ACT1 | Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions |
YLR033W | 7.92 | 1.20E-15 | 0.30 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YJR013W | 7.62 | 1.31E-14 | 0.06 | GPI14 | Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M |
YPR107C | 7.56 | 2.04E-14 | 0.68 | YTH1 | Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation |
YMR211W | 6.88 | 3.02E-12 | 0.51 | DML1 | Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family |
YLR438C-A | 6.37 | 9.40E-11 | 0.21 | LSM3 | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
YIR012W | 6.16 | 3.74E-10 | 0.25 | SQT1 | Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress |