Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKL077W_p | 12.50 | 3.29E-36 | YKL077W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole |
YBR259W_p | 9.04 | 8.14E-20 | YBR259W_p | Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress |
YKL126W | 9.02 | 9.69E-20 | YPK1 | Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication |
YOR202W | 8.68 | 1.97E-18 | HIS3 | Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p |
YDR283C | 8.64 | 2.93E-18 | GCN2 | Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control |
YPR042C | 8.12 | 2.28E-16 | PUF2 | Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins |
YOR196C | 7.28 | 1.61E-13 | LIP5 | Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase |
YJR036C | 6.48 | 4.60E-11 | HUL4 | Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex |
YOL004W | 6.01 | 9.32E-10 | SIN3 | Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity |
YMR317W_p | 5.85 | 2.48E-9 | YMR317W_p | Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene |
YDL020C | 5.83 | 2.77E-9 | RPN4 | Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress |
YDR008C_d | 5.63 | 8.88E-9 | YDR008C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YAL023C | 5.48 | 2.14E-8 | PMT2 | Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication |
YDR354W | 5.33 | 4.93E-8 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YLR082C | 5.21 | 9.25E-8 | SRL2 | Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation |