Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKL055C | 8.31 | 4.86E-17 | OAR1 | Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p |
YMR021C | 7.71 | 6.09E-15 | MAC1 | Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport |
YCR071C | 7.67 | 8.59E-15 | IMG2 | Mitochondrial ribosomal protein of the large subunit |
YNL190W_p | 7.61 | 1.38E-14 | YNL190W_p | Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site |
YHR136C | 6.30 | 1.46E-10 | SPL2 | Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm |
YBR008C | 6.30 | 1.47E-10 | FLR1 | Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress |
YLR425W | 5.49 | 1.99E-8 | TUS1 | Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate |
YFR040W | 5.33 | 4.95E-8 | SAP155 | Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress |
YAL023C | 5.32 | 5.31E-8 | PMT2 | Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication |
YMR069W | 5.22 | 8.91E-8 | NAT4 | N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A |
YMR142C | 5.22 | 9.05E-8 | RPL13B | Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication |
YMR257C | 5.04 | 2.33E-7 | PET111 | Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane |
YJR122W | 4.91 | 4.62E-7 | IBA57 | Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system |
YOR133W | 4.86 | 5.79E-7 | EFT1 | Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication |
YCR087C-A_p | 4.73 | 1.13E-6 | YCR087C-A_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene |