| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YBR072W | 8.18 | 1.38E-16 | HSP26 | Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity |
| YCR075C | 6.99 | 1.38E-12 | ERS1 | Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains |
| YFL010W-A | 5.58 | 1.21E-8 | AUA1 | Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease |
| YPL022W | 5.58 | 1.24E-8 | RAD1 | Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein |
| YKR058W | 5.44 | 2.64E-8 | GLG1 | Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication |
| YIR023W | 5.35 | 4.30E-8 | DAL81 | Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism |
| YDR126W | 5.26 | 7.20E-8 | SWF1 | Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion |
| YMR159C | 5.13 | 1.42E-7 | ATG16 | Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
| YFR006W_p | 4.99 | 2.97E-7 | YFR006W_p | Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene |
| YGL177W_d | 4.89 | 4.99E-7 | YGL177W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YPL158C | 4.74 | 1.05E-6 | AIM44 | Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| YLR313C | 4.48 | 3.81E-6 | SPH1 | Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p |
| YCL056C | 4.46 | 4.08E-6 | PEX34 | Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation |
| YLR306W | 4.32 | 7.71E-6 | UBC12 | Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes |
| YJR073C | 4.32 | 7.89E-6 | OPI3 | Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis |
