Deletion Strain | FD score | P-value | Gene | Gene Description |
---|
YMR017W | 13.00 | 8.58E-39 | SPO20 | Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog |
YMR090W_p | 8.27 | 6.52E-17 | YMR090W_p | Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability |
YIR030C | 7.03 | 1.02E-12 | DCG1 | Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain |
YPR012W_d | 5.90 | 1.86E-9 | YPR012W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene |
YFR039C_p | 5.64 | 8.63E-9 | YFR039C_p | Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces |
YKL057C | 5.60 | 1.05E-8 | NUP120 | Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160 |
YJL038C | 5.60 | 1.07E-8 | LOH1 | Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 |
YMR320W_d | 5.55 | 1.47E-8 | YMR320W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YDR448W | 5.17 | 1.18E-7 | ADA2 | Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes |
YGL158W | 5.13 | 1.48E-7 | RCK1 | Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication |
YGL084C | 5.11 | 1.60E-7 | GUP1 | Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport |
YDL061C | 4.99 | 2.94E-7 | RPS29B | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication |
YDL025C | 4.93 | 4.11E-7 | RTK1 | Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress |
YOR026W | 4.87 | 5.48E-7 | BUB3 | Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p |
YNL093W | 4.82 | 7.23E-7 | YPT53 | Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication |