Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKL213C | 8.70 | 1.62E-18 | DOA1 | WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress |
YNL259C | 6.72 | 9.21E-12 | ATX1 | Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake |
YBR022W | 6.13 | 4.53E-10 | POA1 | Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing |
YNL323W | 5.98 | 1.12E-9 | LEM3 | Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane |
YPL174C | 5.96 | 1.29E-9 | NIP100 | Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) |
YDR234W | 5.70 | 6.16E-9 | LYS4 | Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway |
YIL138C | 5.48 | 2.08E-8 | TPM2 | Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication |
YIL039W | 5.38 | 3.81E-8 | TED1 | Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) |
YPL081W | 5.37 | 3.86E-8 | RPS9A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication |
YDR433W_d | 5.33 | 4.86E-8 | YDR433W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YDR162C | 5.33 | 4.89E-8 | NBP2 | Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM) |
YIL052C | 5.03 | 2.44E-7 | RPL34B | Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication |
YCL025C | 4.86 | 5.82E-7 | AGP1 | Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication |
YLR248W | 4.83 | 6.86E-7 | RCK2 | Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication |
YNL319W_d | 4.72 | 1.16E-6 | YNL319W_d | Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 |