Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPR183W | 10.20 | 6.53E-25 | 5.33 | DPM1 | Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation |
YPR165W | 4.91 | 4.64E-7 | 0.02 | RHO1 | GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) |
YBR049C | 4.88 | 5.20E-7 | 0.66 | REB1 | RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication |
YLL031C | 4.22 | 1.21E-5 | 0.01 | GPI13 | ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein |
YIL048W | 4.21 | 1.28E-5 | 0.07 | NEO1 | Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus |
YOR336W | 4.14 | 1.73E-5 | 0.44 | KRE5 | Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects |
YOR217W | 3.70 | 1.08E-4 | 0.26 | RFC1 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
YGR253C | 3.44 | 2.88E-4 | 0.18 | PUP2 | Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta |
YPL075W | 3.26 | 5.52E-4 | 0.00 | GCR1 | Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p |
YKL060C | 3.26 | 5.58E-4 | 0.00 | FBA1 | Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress |
YPL011C | 3.26 | 5.60E-4 | 0.14 | TAF3 | TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation |
YDL132W | 3.12 | 9.10E-4 | 0.04 | CDC53 | Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation |
YER104W | 3.08 | 0.00105 | 0.16 | RTT105 | Protein with a role in regulation of Ty1 transposition |
YMR093W | 2.92 | 0.00175 | 0.03 | UTP15 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
YBR254C | 2.89 | 0.00192 | 0.10 | TRS20 | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder |