Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YNL103W | 6.03 | 8.31E-10 | 1.81 | MET4 | Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p |
YMR213W | 4.22 | 1.24E-5 | 0.07 | CEF1 | Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p |
YGL047W | 4.14 | 1.71E-5 | 0.04 | ALG13 | Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress |
YLR208W | 4.11 | 2.01E-5 | 0.44 | SEC13 | Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress |
YPR010C | 3.67 | 1.21E-4 | 0.00 | RPA135 | RNA polymerase I second largest subunit A135 |
YFL009W | 3.67 | 1.23E-4 | 0.00 | CDC4 | F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p |
YPR112C | 3.66 | 1.25E-4 | 0.43 | MRD1 | Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region |
YHR070W | 3.24 | 6.06E-4 | 0.09 | TRM5 | tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya |
YOR287C | 3.15 | 8.15E-4 | 0.01 | RRP36 | Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit |
YEL019C | 3.14 | 8.40E-4 | 0.16 | MMS21 | SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination |
YGL122C | 2.98 | 0.00142 | 0.25 | NAB2 | Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress |
YNR043W | 2.74 | 0.00312 | 0.02 | MVD1 | Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer |
YPL233W | 2.72 | 0.00330 | 0.01 | NSL1 | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation |
YKL082C | 2.70 | 0.00342 | 2.76E-4 | RRP14 | Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family |
YEL026W | 2.70 | 0.00342 | 0.04 | SNU13 | RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein |