| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YDR233C | 9.60 | 3.86E-22 | RTN1 | Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication |
| YPL069C | 7.71 | 6.52E-15 | BTS1 | Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic |
| YER145C | 7.30 | 1.49E-13 | FTR1 | High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress |
| YNL338W_d | 6.72 | 8.79E-12 | YNL338W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV |
| YLR111W_d | 6.39 | 8.18E-11 | YLR111W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| YEL017W | 6.23 | 2.29E-10 | GTT3 | Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery |
| YNL271C | 5.67 | 7.04E-9 | BNI1 | Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 |
| YNL001W | 5.52 | 1.72E-8 | DOM34 | Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication |
| YDR399W | 5.49 | 2.06E-8 | HPT1 | Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome |
| YJR115W_p | 5.44 | 2.63E-8 | YJR115W_p | Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication |
| YBR230C | 5.42 | 2.97E-8 | OM14 | Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron |
| YPR046W | 5.37 | 3.98E-8 | MCM16 | Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 |
| YER097W_d | 5.34 | 4.60E-8 | YER097W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YGL158W | 5.18 | 1.11E-7 | RCK1 | Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication |
| YDR442W_d | 5.17 | 1.20E-7 | YDR442W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
