hydroquinidine

(S)-[(2R,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol

An experimental heart treatment.

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PubChem MeSH terms: Anti-Arrhythmia Agents;Parasympatholytics



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2635
Screen concentration 100.0 μM
Source Microsource (Natural product library)
PubChem CID 442912
SMILES CCC1CN2CCC1CC2C(C3=C4C=C(C=CC4=NC=C3)OC)O
Standardized SMILES CCC1CN2CCC1CC2C(O)c3ccnc4ccc(OC)cc34
Molecular weight 326.4326
ALogP 3.12
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.39
% growth inhibition (Hom. pool) 1.18


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 442912
Download HIP data (tab-delimited text)  (excel)
Gene:IMP3(YHR148W)|FD-Score:6.48|P-value:4.53E-11|Clearance:2.72||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA Gene:MAK5(YBR142W)|FD-Score:3.58|P-value:1.71E-4|Clearance:0.51||SGD DESC:Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits Gene:UTP15(YMR093W)|FD-Score:-3.16|P-value:7.98E-4|Clearance:0||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:YDL016C(YDL016C_d)|FD-Score:6.3|P-value:1.44E-10|Clearance:2.72||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication Gene:YOR102W(YOR102W_d)|FD-Score:-3.12|P-value:9.09E-4|Clearance:0||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex Gene:IMP3(YHR148W)|FD-Score:6.48|P-value:4.53E-11|Clearance:2.72||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA Gene:MAK5(YBR142W)|FD-Score:3.58|P-value:1.71E-4|Clearance:0.51||SGD DESC:Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits Gene:UTP15(YMR093W)|FD-Score:-3.16|P-value:7.98E-4|Clearance:0||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:YDL016C(YDL016C_d)|FD-Score:6.3|P-value:1.44E-10|Clearance:2.72||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication Gene:YOR102W(YOR102W_d)|FD-Score:-3.12|P-value:9.09E-4|Clearance:0||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 442912
Download HOP data (tab-delimited text)  (excel)
Gene:AAD4(YDL243C)|FD-Score:4.63|P-value:1.86E-6||SGD DESC:Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin Gene:ACA1(YER045C)|FD-Score:-6.63|P-value:1.64E-11||SGD DESC:ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication Gene:ADY3(YDL239C)|FD-Score:4.04|P-value:2.64E-5||SGD DESC:Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication Gene:AFG1(YEL052W)|FD-Score:-4.34|P-value:7.16E-6||SGD DESC:Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain Gene:AIM21(YIR003W)|FD-Score:-3.73|P-value:9.64E-5||SGD DESC:Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton Gene:AIM36(YMR157C)|FD-Score:-4.24|P-value:1.14E-5||SGD DESC:Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies Gene:AKR2(YOR034C)|FD-Score:-3.81|P-value:6.83E-5||SGD DESC:Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication Gene:ANT1(YPR128C)|FD-Score:3.45|P-value:2.78E-4||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:ARC18(YLR370C)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:BOI2(YER114C)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication Gene:BUL1(YMR275C)|FD-Score:6.93|P-value:2.07E-12||SGD DESC:Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication Gene:CLA4(YNL298W)|FD-Score:-3.24|P-value:5.91E-4||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p Gene:COA4(YLR218C)|FD-Score:3.79|P-value:7.43E-5||SGD DESC:Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors Gene:COS111(YBR203W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:DBR1(YKL149C)|FD-Score:3.38|P-value:3.61E-4||SGD DESC:RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition Gene:DGK1(YOR311C)|FD-Score:-3.25|P-value:5.70E-4||SGD DESC:Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain Gene:ECM18(YDR125C)|FD-Score:-3.83|P-value:6.30E-5||SGD DESC:Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication Gene:EDC3(YEL015W)|FD-Score:-4.1|P-value:2.08E-5||SGD DESC:Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress Gene:ENT3(YJR125C)|FD-Score:4.11|P-value:1.96E-5||SGD DESC:Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p Gene:FAA2(YER015W)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome Gene:GAS3(YMR215W)|FD-Score:4.4|P-value:5.40E-6||SGD DESC:Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation Gene:GAT3(YLR013W)|FD-Score:4.16|P-value:1.56E-5||SGD DESC:Protein containing GATA family zinc finger motifs Gene:GPA2(YER020W)|FD-Score:-3.35|P-value:4.09E-4||SGD DESC:Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:GTT3(YEL017W)|FD-Score:5.16|P-value:1.27E-7||SGD DESC:Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery Gene:HIR3(YJR140C)|FD-Score:-3.5|P-value:2.34E-4||SGD DESC:Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein Gene:ICY1(YMR195W)|FD-Score:-3.53|P-value:2.07E-4||SGD DESC:Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation Gene:IKS1(YJL057C)|FD-Score:-3.95|P-value:3.97E-5||SGD DESC:Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p Gene:IME4(YGL192W)|FD-Score:3.87|P-value:5.52E-5||SGD DESC:Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids Gene:IOC2(YLR095C)|FD-Score:3.83|P-value:6.32E-5||SGD DESC:Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif Gene:JHD1(YER051W)|FD-Score:-3.78|P-value:7.81E-5||SGD DESC:JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe Gene:JLP1(YLL057C)|FD-Score:-4.02|P-value:2.91E-5||SGD DESC:Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation Gene:LIP2(YLR239C)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups Gene:MDM34(YGL219C)|FD-Score:4.8|P-value:7.93E-7||SGD DESC:Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MEK1(YOR351C)|FD-Score:-4.53|P-value:3.00E-6||SGD DESC:Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids Gene:MET8(YBR213W)|FD-Score:5.06|P-value:2.09E-7||SGD DESC:Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis Gene:MMS4(YBR098W)|FD-Score:-3.59|P-value:1.68E-4||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:MOS2(YGR235C)|FD-Score:4.73|P-value:1.10E-6||SGD DESC:Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture Gene:MRPL23(YOR150W)|FD-Score:-3.54|P-value:2.01E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MTD1(YKR080W)|FD-Score:4.55|P-value:2.73E-6||SGD DESC:NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline Gene:NOP16(YER002W)|FD-Score:-3.77|P-value:8.17E-5||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis Gene:OST5(YGL226C-A)|FD-Score:3.69|P-value:1.10E-4||SGD DESC:Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Gene:PDE1(YGL248W)|FD-Score:3.22|P-value:6.33E-4||SGD DESC:Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation Gene:PMU1(YKL128C)|FD-Score:3.24|P-value:5.90E-4||SGD DESC:Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant Gene:PRO2(YOR323C)|FD-Score:4.33|P-value:7.48E-6||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:PRY3(YJL078C)|FD-Score:-4.38|P-value:5.98E-6||SGD DESC:Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p Gene:PYC2(YBR218C)|FD-Score:-5|P-value:2.90E-7||SGD DESC:Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication Gene:RCF1(YML030W)|FD-Score:-4.83|P-value:6.85E-7||SGD DESC:Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast Gene:RCO1(YMR075W)|FD-Score:5.44|P-value:2.64E-8||SGD DESC:Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Gene:REC102(YLR329W)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination Gene:RED1(YLR263W)|FD-Score:4.43|P-value:4.68E-6||SGD DESC:Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p Gene:RGD1(YBR260C)|FD-Score:3.11|P-value:9.42E-4||SGD DESC:GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization Gene:RPL37A(YLR185W)|FD-Score:4.26|P-value:1.00E-5||SGD DESC:Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication Gene:RTT10(YPL183C)|FD-Score:-5.53|P-value:1.63E-8||SGD DESC:WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6 Gene:SAP190(YKR028W)|FD-Score:4.08|P-value:2.22E-5||SGD DESC:Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication Gene:SOV1(YMR066W)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:Mitochondrial protein of unknown function Gene:SWM2(YNR004W_p)|FD-Score:3.13|P-value:8.63E-4||SGD DESC:Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds Gene:TCA17(YEL048C)|FD-Score:3.39|P-value:3.53E-4||SGD DESC:Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder Gene:TEF4(YKL081W)|FD-Score:3.33|P-value:4.36E-4||SGD DESC:Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex Gene:TOM70(YNL121C)|FD-Score:3.62|P-value:1.47E-4||SGD DESC:Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication Gene:YAL045C(YAL045C_d)|FD-Score:-3.45|P-value:2.78E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A Gene:YBL036C(YBL036C)|FD-Score:-3.22|P-value:6.44E-4||SGD DESC:Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS Gene:YBL071C(YBL071C_d)|FD-Score:3.33|P-value:4.32E-4||SGD DESC:Dubious open reading frame, predicted protein contains a peroxisomal targeting signal Gene:YCR001W(YCR001W_d)|FD-Score:-3.15|P-value:8.07E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene Gene:YCR064C(YCR064C_d)|FD-Score:-4.34|P-value:7.19E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 Gene:YDL041W(YDL041W_d)|FD-Score:3.29|P-value:5.00E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C Gene:YDL187C(YDL187C_d)|FD-Score:3.99|P-value:3.31E-5||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR262W(YDR262W_p)|FD-Score:-4.27|P-value:9.86E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment Gene:YER152C(YER152C)|FD-Score:-3.49|P-value:2.43E-4||SGD DESC:Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene Gene:YGL101W(YGL101W_p)|FD-Score:3.3|P-value:4.90E-4||SGD DESC:Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p Gene:YGR117C(YGR117C_p)|FD-Score:-3.67|P-value:1.20E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YHR125W(YHR125W_d)|FD-Score:4.82|P-value:7.14E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL046W-A(YIL046W-A_p)|FD-Score:5.36|P-value:4.13E-8||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJL027C(YJL027C_p)|FD-Score:-3.25|P-value:5.86E-4||SGD DESC:Putative protein of unknown function Gene:YJL064W(YJL064W_d)|FD-Score:-7.54|P-value:2.26E-14||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 Gene:YJL160C(YJL160C_p)|FD-Score:4.24|P-value:1.13E-5||SGD DESC:Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication Gene:YKL162C-A(YKL162C-A_d)|FD-Score:-3.76|P-value:8.39E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR046C(YLR046C_p)|FD-Score:4.36|P-value:6.56E-6||SGD DESC:Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance Gene:YLR173W(YLR173W_p)|FD-Score:3.72|P-value:9.91E-5||SGD DESC:Putative protein of unknown function Gene:YLR406C-A(YLR406C-A_p)|FD-Score:5.99|P-value:1.08E-9||SGD DESC:Putative protein of unknown function Gene:YLR422W(YLR422W_p)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein Gene:YMR193C-A(YMR193C-A_d)|FD-Score:-3.86|P-value:5.72E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL205C(YNL205C_d)|FD-Score:-3.54|P-value:2.02E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR228C(YOR228C)|FD-Score:6.6|P-value:2.07E-11||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YTP1(YNL237W)|FD-Score:3.09|P-value:9.87E-4||SGD DESC:Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins Gene:AAD4(YDL243C)|FD-Score:4.63|P-value:1.86E-6||SGD DESC:Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin Gene:ACA1(YER045C)|FD-Score:-6.63|P-value:1.64E-11||SGD DESC:ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication Gene:ADY3(YDL239C)|FD-Score:4.04|P-value:2.64E-5||SGD DESC:Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication Gene:AFG1(YEL052W)|FD-Score:-4.34|P-value:7.16E-6||SGD DESC:Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain Gene:AIM21(YIR003W)|FD-Score:-3.73|P-value:9.64E-5||SGD DESC:Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton Gene:AIM36(YMR157C)|FD-Score:-4.24|P-value:1.14E-5||SGD DESC:Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies Gene:AKR2(YOR034C)|FD-Score:-3.81|P-value:6.83E-5||SGD DESC:Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication Gene:ANT1(YPR128C)|FD-Score:3.45|P-value:2.78E-4||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:ARC18(YLR370C)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:BOI2(YER114C)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication Gene:BUL1(YMR275C)|FD-Score:6.93|P-value:2.07E-12||SGD DESC:Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication Gene:CLA4(YNL298W)|FD-Score:-3.24|P-value:5.91E-4||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p Gene:COA4(YLR218C)|FD-Score:3.79|P-value:7.43E-5||SGD DESC:Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors Gene:COS111(YBR203W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:DBR1(YKL149C)|FD-Score:3.38|P-value:3.61E-4||SGD DESC:RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition Gene:DGK1(YOR311C)|FD-Score:-3.25|P-value:5.70E-4||SGD DESC:Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain Gene:ECM18(YDR125C)|FD-Score:-3.83|P-value:6.30E-5||SGD DESC:Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication Gene:EDC3(YEL015W)|FD-Score:-4.1|P-value:2.08E-5||SGD DESC:Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress Gene:ENT3(YJR125C)|FD-Score:4.11|P-value:1.96E-5||SGD DESC:Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p Gene:FAA2(YER015W)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome Gene:GAS3(YMR215W)|FD-Score:4.4|P-value:5.40E-6||SGD DESC:Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation Gene:GAT3(YLR013W)|FD-Score:4.16|P-value:1.56E-5||SGD DESC:Protein containing GATA family zinc finger motifs Gene:GPA2(YER020W)|FD-Score:-3.35|P-value:4.09E-4||SGD DESC:Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:GTT3(YEL017W)|FD-Score:5.16|P-value:1.27E-7||SGD DESC:Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery Gene:HIR3(YJR140C)|FD-Score:-3.5|P-value:2.34E-4||SGD DESC:Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein Gene:ICY1(YMR195W)|FD-Score:-3.53|P-value:2.07E-4||SGD DESC:Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation Gene:IKS1(YJL057C)|FD-Score:-3.95|P-value:3.97E-5||SGD DESC:Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p Gene:IME4(YGL192W)|FD-Score:3.87|P-value:5.52E-5||SGD DESC:Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids Gene:IOC2(YLR095C)|FD-Score:3.83|P-value:6.32E-5||SGD DESC:Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif Gene:JHD1(YER051W)|FD-Score:-3.78|P-value:7.81E-5||SGD DESC:JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe Gene:JLP1(YLL057C)|FD-Score:-4.02|P-value:2.91E-5||SGD DESC:Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation Gene:LIP2(YLR239C)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups Gene:MDM34(YGL219C)|FD-Score:4.8|P-value:7.93E-7||SGD DESC:Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MEK1(YOR351C)|FD-Score:-4.53|P-value:3.00E-6||SGD DESC:Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids Gene:MET8(YBR213W)|FD-Score:5.06|P-value:2.09E-7||SGD DESC:Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis Gene:MMS4(YBR098W)|FD-Score:-3.59|P-value:1.68E-4||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:MOS2(YGR235C)|FD-Score:4.73|P-value:1.10E-6||SGD DESC:Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture Gene:MRPL23(YOR150W)|FD-Score:-3.54|P-value:2.01E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MTD1(YKR080W)|FD-Score:4.55|P-value:2.73E-6||SGD DESC:NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline Gene:NOP16(YER002W)|FD-Score:-3.77|P-value:8.17E-5||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis Gene:OST5(YGL226C-A)|FD-Score:3.69|P-value:1.10E-4||SGD DESC:Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Gene:PDE1(YGL248W)|FD-Score:3.22|P-value:6.33E-4||SGD DESC:Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation Gene:PMU1(YKL128C)|FD-Score:3.24|P-value:5.90E-4||SGD DESC:Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant Gene:PRO2(YOR323C)|FD-Score:4.33|P-value:7.48E-6||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:PRY3(YJL078C)|FD-Score:-4.38|P-value:5.98E-6||SGD DESC:Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p Gene:PYC2(YBR218C)|FD-Score:-5|P-value:2.90E-7||SGD DESC:Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication Gene:RCF1(YML030W)|FD-Score:-4.83|P-value:6.85E-7||SGD DESC:Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast Gene:RCO1(YMR075W)|FD-Score:5.44|P-value:2.64E-8||SGD DESC:Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Gene:REC102(YLR329W)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination Gene:RED1(YLR263W)|FD-Score:4.43|P-value:4.68E-6||SGD DESC:Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p Gene:RGD1(YBR260C)|FD-Score:3.11|P-value:9.42E-4||SGD DESC:GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization Gene:RPL37A(YLR185W)|FD-Score:4.26|P-value:1.00E-5||SGD DESC:Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication Gene:RTT10(YPL183C)|FD-Score:-5.53|P-value:1.63E-8||SGD DESC:WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6 Gene:SAP190(YKR028W)|FD-Score:4.08|P-value:2.22E-5||SGD DESC:Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication Gene:SOV1(YMR066W)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:Mitochondrial protein of unknown function Gene:SWM2(YNR004W_p)|FD-Score:3.13|P-value:8.63E-4||SGD DESC:Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds Gene:TCA17(YEL048C)|FD-Score:3.39|P-value:3.53E-4||SGD DESC:Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder Gene:TEF4(YKL081W)|FD-Score:3.33|P-value:4.36E-4||SGD DESC:Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex Gene:TOM70(YNL121C)|FD-Score:3.62|P-value:1.47E-4||SGD DESC:Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication Gene:YAL045C(YAL045C_d)|FD-Score:-3.45|P-value:2.78E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A Gene:YBL036C(YBL036C)|FD-Score:-3.22|P-value:6.44E-4||SGD DESC:Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS Gene:YBL071C(YBL071C_d)|FD-Score:3.33|P-value:4.32E-4||SGD DESC:Dubious open reading frame, predicted protein contains a peroxisomal targeting signal Gene:YCR001W(YCR001W_d)|FD-Score:-3.15|P-value:8.07E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene Gene:YCR064C(YCR064C_d)|FD-Score:-4.34|P-value:7.19E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 Gene:YDL041W(YDL041W_d)|FD-Score:3.29|P-value:5.00E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C Gene:YDL187C(YDL187C_d)|FD-Score:3.99|P-value:3.31E-5||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR262W(YDR262W_p)|FD-Score:-4.27|P-value:9.86E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment Gene:YER152C(YER152C)|FD-Score:-3.49|P-value:2.43E-4||SGD DESC:Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene Gene:YGL101W(YGL101W_p)|FD-Score:3.3|P-value:4.90E-4||SGD DESC:Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p Gene:YGR117C(YGR117C_p)|FD-Score:-3.67|P-value:1.20E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YHR125W(YHR125W_d)|FD-Score:4.82|P-value:7.14E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL046W-A(YIL046W-A_p)|FD-Score:5.36|P-value:4.13E-8||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJL027C(YJL027C_p)|FD-Score:-3.25|P-value:5.86E-4||SGD DESC:Putative protein of unknown function Gene:YJL064W(YJL064W_d)|FD-Score:-7.54|P-value:2.26E-14||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 Gene:YJL160C(YJL160C_p)|FD-Score:4.24|P-value:1.13E-5||SGD DESC:Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication Gene:YKL162C-A(YKL162C-A_d)|FD-Score:-3.76|P-value:8.39E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR046C(YLR046C_p)|FD-Score:4.36|P-value:6.56E-6||SGD DESC:Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance Gene:YLR173W(YLR173W_p)|FD-Score:3.72|P-value:9.91E-5||SGD DESC:Putative protein of unknown function Gene:YLR406C-A(YLR406C-A_p)|FD-Score:5.99|P-value:1.08E-9||SGD DESC:Putative protein of unknown function Gene:YLR422W(YLR422W_p)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein Gene:YMR193C-A(YMR193C-A_d)|FD-Score:-3.86|P-value:5.72E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL205C(YNL205C_d)|FD-Score:-3.54|P-value:2.02E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR228C(YOR228C)|FD-Score:6.6|P-value:2.07E-11||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YTP1(YNL237W)|FD-Score:3.09|P-value:9.87E-4||SGD DESC:Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins

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Top 15 HET fitness defect scores (HIP)

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Deletion Strain FD score P-value Clearance Gene Gene Description
YHR148W6.484.53E-112.72IMP3Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
YDL016C_d6.301.44E-102.72YDL016C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication
YBR142W3.581.71E-40.51MAK5Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
YGR191W3.080.001050.19HIP1High-affinity histidine permease, also involved in the transport of manganese ions
YLR115W2.890.001920.01CFT2Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.
YLR029C2.880.002010.05RPL15ARibosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
YOL005C2.820.002390.01RPB11RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YDR188W2.810.002490.03CCT6Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
YAL034C-B_d2.780.002710.02YAL034C-B_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL102C_d2.760.002900.02YGL102C_dDubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YDR145W2.740.003070.18TAF12Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
YML091C2.560.005180.03RPM2Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YBR004C2.540.005590.01GPI18Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
YGL145W2.530.005730.07TIP20Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
YKL182W2.460.006880.01FAS1Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities

Top 15 HOM fitness defect scores (HOP)

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Deletion Strain FD score P-value Gene Gene Description
YMR275C6.932.07E-12BUL1Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication
YOR228C6.602.07E-11YOR228CProtein of unknown function, localized to the mitochondrial outer membrane
YLR406C-A_p5.991.08E-9YLR406C-A_pPutative protein of unknown function
YMR075W5.442.64E-8RCO1Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
YIL046W-A_p5.364.13E-8YIL046W-A_pPutative protein of unknown function; identified by expression profiling and mass spectrometry
YEL017W5.161.27E-7GTT3Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YBR213W5.062.09E-7MET8Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
YHR125W_d4.827.14E-7YHR125W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL219C4.807.93E-7MDM34Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
YGR235C4.731.10E-6MOS2Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
YDL243C4.631.86E-6AAD4Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
YKR080W4.552.73E-6MTD1NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
YLR263W4.434.68E-6RED1Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
YMR215W4.405.40E-6GAS3Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation
YLR046C_p4.366.56E-6YLR046C_pPutative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance

GO enrichment analysis for SGTC_2635
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0841.11E-10SGTC_26335,7-dihydroxyisoflavone 100.0 μMMicrosource (Natural product library)53773810.0609756
0.0706.04E-8SGTC_26323-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100.0 μMMicrosource (Natural product library)68577840.0674157
0.0681.49E-7SGTC_7710250-0039 27.3 μMChemDiv (Drug-like library)30051150.0344828
0.0604.64E-6SGTC_11901486-1332 13.0 μMChemDiv (Drug-like library)41500460.09375
0.0552.77E-5SGTC_2501sodium tetradecyl sulfate 13.4 μMMicrosource (Natural product library)236657720.0609756
0.0533.98E-5SGTC_29619083290 32.5 μMChembridge (Drug-like library)177414900.0722892
0.0534.88E-5SGTC_21205538279 152.0 μMChembridge (Fragment library)20581970.037037
0.0501.13E-4SGTC_1230083-0120 66.7 μMChemDiv (Drug-like library)160017010.0824742
0.0482.06E-4SGTC_23945221648 200.0 μMMiscellaneous7885860.0632911
0.0472.72E-4SGTC_20665222451 176.0 μMChembridge (Fragment library)22811470.0853659heme biosynthesis & mitochondrial translocase
0.0464.22E-4SGTC_20914-phenylthiadiazole 200.0 μMChembridge (Fragment library)2700100.056338
0.0456.04E-4SGTC_479n-linoleoylglycine 10.0 μMICCB bioactive library64333460.047619
0.0446.96E-4SGTC_6604031-1742 102.0 μMChemDiv (Drug-like library)67387060.0625redox potentiating
0.0439.43E-4SGTC_260nsc-65238 4.0 μMMiscellaneous32462520.116279endomembrane recycling
0.0430.00108SGTC_1010490-5701 117.5 μMChemDiv (Drug-like library)46616690.0740741

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_7734358-145744.6 μM0.2692311186886ChemDiv (Drug-like library)352.38383.73716
SGTC_1547harmine94.2 μM0.2428575280953Miscellaneous212.247182.43812ergosterol biosynthesis
SGTC_2525harmine47.85 μM0.2428575280953Miscellaneous212.247182.43812ergosterol biosynthesis
SGTC_3204092-08465.34 μM0.23751359356ChemDiv (Drug-like library)394.549664.9704ergosterol depletion effects on membrane
SGTC_1793st04825672.23 μM0.234568672022TimTec (Natural product derivative library)274.315022.51113
SGTC_1615st00265686.5 μM0.229731584458TimTec (Natural product derivative library)231.253821.1424redox potentiating
SGTC_3084092-1169104 μM0.2266672268590ChemDiv (Drug-like library)346.851123.8514plasma membrane duress
SGTC_2983902267112.99 μM0.2247196405161Chembridge (Drug-like library)373.472523.1320760S ribosome export
SGTC_14394092-116846 μM0.2179492886240ChemDiv (Drug-like library)346.851123.8514
SGTC_2698st07769767.5 μM0.2142863154499TimTec (Natural product derivative library)296.406664.12322
SGTC_2559tetrahydrosappanone a trimethyl ether100 μM0.21256708784Microsource (Natural product library)330.374983.00615