| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YHR147C | 7.04 | 9.78E-13 | MRPL6 | Mitochondrial ribosomal protein of the large subunit |
| YMR275C | 6.30 | 1.51E-10 | BUL1 | Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication |
| YDR138W | 6.16 | 3.73E-10 | HPR1 | Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p |
| YDL020C | 6.15 | 3.80E-10 | RPN4 | Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress |
| YLL048C | 5.68 | 6.70E-9 | YBT1 | Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters |
| YJR140C | 5.19 | 1.07E-7 | HIR3 | Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein |
| YOL110W | 5.01 | 2.78E-7 | SHR5 | Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization |
| YIL107C | 5.00 | 2.88E-7 | PFK26 | 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A |
| YCL025C | 4.82 | 7.18E-7 | AGP1 | Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication |
| YML013W | 4.79 | 8.47E-7 | UBX2 | Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis |
| YBL093C | 4.76 | 9.57E-7 | ROX3 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme |
| YNL175C | 4.69 | 1.35E-6 | NOP13 | Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress |
| YLR279W_d | 4.63 | 1.80E-6 | YLR279W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YMR086C-A_d | 4.61 | 1.99E-6 | YMR086C-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YJL210W | 4.56 | 2.53E-6 | PEX2 | RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import |
