Deletion Strain | FD score | P-value | Gene | Gene Description |
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YHL039W | 24.40 | 5.61E-132 | EFM1 | Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
YMR166C_p | 24.00 | 2.52E-127 | YMR166C_p | Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene |
YDL223C | 20.70 | 1.70E-95 | HBT1 | Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis |
YMR289W | 20.10 | 7.41E-90 | ABZ2 | Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis |
YOR133W | 16.90 | 1.26E-64 | EFT1 | Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication |
YGL095C | 12.10 | 8.36E-34 | VPS45 | Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment |
YPL157W | 11.90 | 7.67E-33 | TGS1 | Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs |
YGL118C_d | 11.90 | 7.77E-33 | YGL118C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YLR133W | 10.50 | 3.07E-26 | CKI1 | Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication |
YMR262W_p | 10.10 | 1.90E-24 | YMR262W_p | Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene |
YMR256C | 8.18 | 1.45E-16 | COX7 | Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain |
YGL041C_d | 8.03 | 5.01E-16 | YGL041C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YPL141C | 7.90 | 1.45E-15 | FRK1 | Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication |
YBR170C | 7.62 | 1.32E-14 | NPL4 | Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) |
YOR064C | 6.76 | 6.98E-12 | YNG1 | Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1 |