guaiazulene

1,4-dimethyl-7-propan-2-ylazulene

A coloring agent.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2644
Screen concentration 100.0 μM
Source Microsource (Natural product library)
PubChem CID 3515
SMILES CC1=C2C=CC(=C2C=C(C=C1)C(C)C)C
Standardized SMILES CC(C)c1ccc(C)c2ccc(C)c2c1
Molecular weight 198.3034
ALogP 4.91
H-bond donor count 0
H-bond acceptor count 0
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 2.01
% growth inhibition (Hom. pool) 4.42


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3515
Download HIP data (tab-delimited text)  (excel)
Gene:CAB3(YKL088W)|FD-Score:-3.77|P-value:8.09E-5|Clearance:0||SGD DESC:Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC Gene:IPL1(YPL209C)|FD-Score:-4|P-value:3.17E-5|Clearance:0||SGD DESC:Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest Gene:NUP57(YGR119C)|FD-Score:-3.11|P-value:9.48E-4|Clearance:0||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) Gene:CAB3(YKL088W)|FD-Score:-3.77|P-value:8.09E-5|Clearance:0||SGD DESC:Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC Gene:IPL1(YPL209C)|FD-Score:-4|P-value:3.17E-5|Clearance:0||SGD DESC:Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest Gene:NUP57(YGR119C)|FD-Score:-3.11|P-value:9.48E-4|Clearance:0||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3515
Download HOP data (tab-delimited text)  (excel)
Gene:BUD30(YDL151C_d)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:BUD4(YJR092W)|FD-Score:3.28|P-value:5.15E-4||SGD DESC:Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p Gene:CAR1(YPL111W)|FD-Score:-4.23|P-value:1.19E-5||SGD DESC:Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance Gene:CSF1(YLR087C)|FD-Score:-3.33|P-value:4.38E-4||SGD DESC:Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:DFM1(YDR411C)|FD-Score:3.89|P-value:5.08E-5||SGD DESC:Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p Gene:EMP24(YGL200C)|FD-Score:3.11|P-value:9.31E-4||SGD DESC:Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles Gene:GIT1(YCR098C)|FD-Score:4.28|P-value:9.39E-6||SGD DESC:Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability Gene:GOR1(YNL274C)|FD-Score:3.89|P-value:4.91E-5||SGD DESC:Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:MFM1(YPL060W)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p Gene:MUS81(YDR386W)|FD-Score:3.27|P-value:5.30E-4||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:NVJ1(YHR195W)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Gene:PPR1(YLR014C)|FD-Score:-3.32|P-value:4.56E-4||SGD DESC:Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p Gene:PTK2(YJR059W)|FD-Score:3.27|P-value:5.42E-4||SGD DESC:Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake Gene:REV3(YPL167C)|FD-Score:-3.21|P-value:6.73E-4||SGD DESC:Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair Gene:SRO9(YCL037C)|FD-Score:3.98|P-value:3.51E-5||SGD DESC:Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication Gene:YBR134W(YBR134W_d)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDL068W(YDL068W_d)|FD-Score:-3.1|P-value:9.64E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL187C(YDL187C_d)|FD-Score:-3.2|P-value:6.84E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR010C(YDR010C_d)|FD-Score:-3.33|P-value:4.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR067C(YGR067C_p)|FD-Score:4.23|P-value:1.17E-5||SGD DESC:Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p Gene:YJR146W(YJR146W_p)|FD-Score:3.38|P-value:3.59E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2 Gene:YLR169W(YLR169W_d)|FD-Score:3.34|P-value:4.12E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML082W(YML082W_p)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene Gene:YNR042W(YNR042W_d)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 Gene:BUD30(YDL151C_d)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:BUD4(YJR092W)|FD-Score:3.28|P-value:5.15E-4||SGD DESC:Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p Gene:CAR1(YPL111W)|FD-Score:-4.23|P-value:1.19E-5||SGD DESC:Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance Gene:CSF1(YLR087C)|FD-Score:-3.33|P-value:4.38E-4||SGD DESC:Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:DFM1(YDR411C)|FD-Score:3.89|P-value:5.08E-5||SGD DESC:Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p Gene:EMP24(YGL200C)|FD-Score:3.11|P-value:9.31E-4||SGD DESC:Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles Gene:GIT1(YCR098C)|FD-Score:4.28|P-value:9.39E-6||SGD DESC:Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability Gene:GOR1(YNL274C)|FD-Score:3.89|P-value:4.91E-5||SGD DESC:Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:MFM1(YPL060W)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p Gene:MUS81(YDR386W)|FD-Score:3.27|P-value:5.30E-4||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:NVJ1(YHR195W)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Gene:PPR1(YLR014C)|FD-Score:-3.32|P-value:4.56E-4||SGD DESC:Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p Gene:PTK2(YJR059W)|FD-Score:3.27|P-value:5.42E-4||SGD DESC:Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake Gene:REV3(YPL167C)|FD-Score:-3.21|P-value:6.73E-4||SGD DESC:Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair Gene:SRO9(YCL037C)|FD-Score:3.98|P-value:3.51E-5||SGD DESC:Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication Gene:YBR134W(YBR134W_d)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDL068W(YDL068W_d)|FD-Score:-3.1|P-value:9.64E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL187C(YDL187C_d)|FD-Score:-3.2|P-value:6.84E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR010C(YDR010C_d)|FD-Score:-3.33|P-value:4.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR067C(YGR067C_p)|FD-Score:4.23|P-value:1.17E-5||SGD DESC:Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p Gene:YJR146W(YJR146W_p)|FD-Score:3.38|P-value:3.59E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2 Gene:YLR169W(YLR169W_d)|FD-Score:3.34|P-value:4.12E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML082W(YML082W_p)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene Gene:YNR042W(YNR042W_d)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDL060W3.050.001130.17TSR1Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
YJL167W2.900.001850.17ERG20Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YBL035C2.880.001970.17POL12B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
YPR180W2.800.002570.17AOS1Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YGR009C2.790.002670.17SEC9t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
YHR085W2.740.003090.17IPI1Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene
YMR079W2.690.003560.17SEC14Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
YJL031C2.640.004130.17BET4Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
YDL103C2.620.004430.17QRI1UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress
YLR336C2.580.004940.17SGD1Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia
YMR117C2.570.005140.17SPC24Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YDR086C2.520.005900.17SSS1Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YDR211W2.510.006090.17GCD6Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
YBR167C2.340.009660.01POP7Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YGL061C2.330.009820.02DUO1Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YCR098C4.289.39E-6GIT1Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
YGR067C_p4.231.17E-5YGR067C_pPutative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YCL037C3.983.51E-5SRO9Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication
YNL274C3.894.91E-5GOR1Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
YDR411C3.895.08E-5DFM1Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
YNR042W_d3.551.92E-4YNR042W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
YBR134W_d3.542.02E-4YBR134W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL151C_d3.512.26E-4BUD30_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YML082W_p3.502.33E-4YML082W_pPutative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene
YHR195W3.482.49E-4NVJ1Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
YJR146W_p3.383.59E-4YJR146W_pProtein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
YLR169W_d3.344.12E-4YLR169W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR092W3.285.15E-4BUD4Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
YDR386W3.275.30E-4MUS81Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
YJR059W3.275.42E-4PTK2Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake

GO enrichment analysis for SGTC_2644
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0945.24E-13SGTC_23057443522 69.2 μMChembridge (Fragment library)54158860.0740741
0.0713.92E-8SGTC_2746daunorubicin 9.9 μMMiscellaneous303230.0465116anthracycline transcription coupled DNA repair
0.0706.96E-8SGTC_447ml7 120.0 μMICCB bioactive library42160.0740741NEO1-PIK1
0.0681.56E-7SGTC_244nsc-207895 1.3 μMMiscellaneous426400.0689655DNA damage response
0.0647.83E-7SGTC_29789011784 43.0 μMChembridge (Drug-like library)29949340.0740741
0.0612.71E-6SGTC_20305175110 200.0 μMChembridge (Fragment library)28319860.0638298Golgi
0.0603.62E-6SGTC_30149081533 49.5 μMChembridge (Drug-like library)213672650.0833333
0.0604.38E-6SGTC_22847945075 39.2 μMChembridge (Fragment library)12454020.0714286mitochondrial processes
0.0595.64E-6SGTC_23869075165 157.4 μMChembridge (Fragment library)164522770.08
0.0571.32E-5SGTC_15120259-0544 12.2 μMChemDiv (Drug-like library)184760.0740741
0.0552.57E-5SGTC_1082camptothecin 424.9 nMTimTec (Natural product library)25380.0704225DNA damage response
0.0543.28E-5SGTC_13762910-0861 41.3 μMChemDiv (Drug-like library)11128590.0923077
0.0543.42E-5SGTC_30219087658 49.5 μMChembridge (Drug-like library)252370420.115385
0.0534.55E-5SGTC_20835306046 65.9 μMChembridge (Fragment library)5398370.0652174
0.0526.46E-5SGTC_1663st014140 55.4 μMTimTec (Natural product derivative library)42071200.044776160S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_6990375-0592111 μM0.27907762578ChemDiv (Drug-like library)251.326283.71822iron homeostasis
SGTC_11453546-059710.2 μM0.244898875334ChemDiv (Drug-like library)293.406024.39812mitochondrial processes
SGTC_2115tiliquinol12.77 μM0.24324371208Chembridge (Fragment library)159.184562.2612
SGTC_260nsc-652383.99 μM0.2352943246252Miscellaneous407.588183.84623endomembrane recycling
SGTC_249418-aminoabieta-8,11,13-triene sulfate3.66 μM0.23529416725076Microsource (Natural product library)383.545324.25835
SGTC_1553gossypol38.6 μM0.2272733503TimTec (Pure natural product library)518.55446.59268
SGTC_2516gossypol71.55 μM0.2272733503TimTec (Pure natural product library)518.55446.59268
SGTC_2536dehydroabietamide32.04 μM0.2264153983547Microsource (Natural product library)299.450364.76211
SGTC_13311472-004976.2 μM0.2244924051409ChemDiv (Drug-like library)286.325723.57824
SGTC_3312913333071.43 μM0.21739117617324Chembridge (Drug-like library)307.3830233.87914
SGTC_9221866-0035480 μM0.2156863156169ChemDiv (Drug-like library)305.373663.30924excess fatty acid