retinol

(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol

A vitamin A analog and teratogen.

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PubChem MeSH terms: Vitamins



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2646
Screen concentration 96.8 μM
Source Microsource (Natural product library)
PubChem CID 445354
SMILES CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CCO)C)C
Standardized SMILES CC(=CCO)C=CC=C(C)C=CC1=C(C)CCCC1(C)C
Molecular weight 286.4516
ALogP 5.32
H-bond donor count 1
H-bond acceptor count 1
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 0.07
% growth inhibition (Hom. pool) 2.24


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 445354
Download HIP data (tab-delimited text)  (excel)
Gene:AOS1(YPR180W)|FD-Score:3.36|P-value:3.93E-4|Clearance:0.04||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:BRL1(YHR036W)|FD-Score:3.11|P-value:9.50E-4|Clearance:0.13||SGD DESC:Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export Gene:CDS1(YBR029C)|FD-Score:-3.37|P-value:3.73E-4|Clearance:0||SGD DESC:Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids Gene:DPB11(YJL090C)|FD-Score:4.23|P-value:1.18E-5|Clearance:0.33||SGD DESC:DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress Gene:GPN2(YOR262W)|FD-Score:-5.97|P-value:1.21E-9|Clearance:0||SGD DESC:Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion Gene:KRI1(YNL308C)|FD-Score:3.43|P-value:3.01E-4|Clearance:0.07||SGD DESC:Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p Gene:LCB2(YDR062W)|FD-Score:3.43|P-value:2.99E-4|Clearance:0||SGD DESC:Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine Gene:MAS1(YLR163C)|FD-Score:3.12|P-value:8.93E-4|Clearance:0.02||SGD DESC:Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:MED6(YHR058C)|FD-Score:-3.24|P-value:6.06E-4|Clearance:0||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress Gene:POP5(YAL033W)|FD-Score:3.32|P-value:4.48E-4|Clearance:0.05||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:PRP3(YDR473C)|FD-Score:4|P-value:3.11E-5|Clearance:0.33||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RPA43(YOR340C)|FD-Score:3.99|P-value:3.24E-5|Clearance:0.33||SGD DESC:RNA polymerase I subunit A43 Gene:RPF2(YKR081C)|FD-Score:-3.14|P-value:8.57E-4|Clearance:0||SGD DESC:Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles Gene:RPL10(YLR075W)|FD-Score:-3.59|P-value:1.65E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects Gene:RPL32(YBL092W)|FD-Score:-3.32|P-value:4.58E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog Gene:RPN2(YIL075C)|FD-Score:3.76|P-value:8.34E-5|Clearance:0.33||SGD DESC:Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress Gene:SEC9(YGR009C)|FD-Score:3.17|P-value:7.75E-4|Clearance:0.04||SGD DESC:t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog Gene:SMT3(YDR510W)|FD-Score:3.27|P-value:5.30E-4|Clearance:0.11||SGD DESC:Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2 Gene:AOS1(YPR180W)|FD-Score:3.36|P-value:3.93E-4|Clearance:0.04||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:BRL1(YHR036W)|FD-Score:3.11|P-value:9.50E-4|Clearance:0.13||SGD DESC:Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export Gene:CDS1(YBR029C)|FD-Score:-3.37|P-value:3.73E-4|Clearance:0||SGD DESC:Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids Gene:DPB11(YJL090C)|FD-Score:4.23|P-value:1.18E-5|Clearance:0.33||SGD DESC:DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress Gene:GPN2(YOR262W)|FD-Score:-5.97|P-value:1.21E-9|Clearance:0||SGD DESC:Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion Gene:KRI1(YNL308C)|FD-Score:3.43|P-value:3.01E-4|Clearance:0.07||SGD DESC:Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p Gene:LCB2(YDR062W)|FD-Score:3.43|P-value:2.99E-4|Clearance:0||SGD DESC:Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine Gene:MAS1(YLR163C)|FD-Score:3.12|P-value:8.93E-4|Clearance:0.02||SGD DESC:Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:MED6(YHR058C)|FD-Score:-3.24|P-value:6.06E-4|Clearance:0||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress Gene:POP5(YAL033W)|FD-Score:3.32|P-value:4.48E-4|Clearance:0.05||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:PRP3(YDR473C)|FD-Score:4|P-value:3.11E-5|Clearance:0.33||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RPA43(YOR340C)|FD-Score:3.99|P-value:3.24E-5|Clearance:0.33||SGD DESC:RNA polymerase I subunit A43 Gene:RPF2(YKR081C)|FD-Score:-3.14|P-value:8.57E-4|Clearance:0||SGD DESC:Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles Gene:RPL10(YLR075W)|FD-Score:-3.59|P-value:1.65E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects Gene:RPL32(YBL092W)|FD-Score:-3.32|P-value:4.58E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog Gene:RPN2(YIL075C)|FD-Score:3.76|P-value:8.34E-5|Clearance:0.33||SGD DESC:Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress Gene:SEC9(YGR009C)|FD-Score:3.17|P-value:7.75E-4|Clearance:0.04||SGD DESC:t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog Gene:SMT3(YDR510W)|FD-Score:3.27|P-value:5.30E-4|Clearance:0.11||SGD DESC:Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 445354
Download HOP data (tab-delimited text)  (excel)
Gene:ARK1(YNL020C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication Gene:ATG15(YCR068W)|FD-Score:3.14|P-value:8.41E-4||SGD DESC:Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Gene:BNA3(YJL060W)|FD-Score:3.14|P-value:8.52E-4||SGD DESC:Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate Gene:BSC6(YOL137W)|FD-Score:3.16|P-value:7.91E-4||SGD DESC:Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression Gene:CBR1(YIL043C)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia Gene:CEM1(YER061C)|FD-Score:3.42|P-value:3.08E-4||SGD DESC:Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Gene:CIT1(YNR001C)|FD-Score:5.71|P-value:5.52E-9||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication Gene:CST26(YBR042C)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication Gene:CTI6(YPL181W)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain Gene:DUG3(YNL191W)|FD-Score:4.6|P-value:2.09E-6||SGD DESC:Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) Gene:EAF1(YDR359C)|FD-Score:3.91|P-value:4.62E-5||SGD DESC:Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 Gene:ECM33(YBR078W)|FD-Score:-3.72|P-value:9.98E-5||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:ERV14(YGL054C)|FD-Score:4.11|P-value:2.02E-5||SGD DESC:COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication Gene:FMP10(YER182W_p)|FD-Score:3.76|P-value:8.48E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FYV7(YLR068W)|FD-Score:3.23|P-value:6.30E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin Gene:GAD1(YMR250W)|FD-Score:3.18|P-value:7.29E-4||SGD DESC:Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress Gene:GLC8(YMR311C)|FD-Score:3.89|P-value:5.06E-5||SGD DESC:Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress Gene:HUT1(YPL244C)|FD-Score:3.92|P-value:4.34E-5||SGD DESC:Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 Gene:IRC16(YPR038W_d)|FD-Score:-3.1|P-value:9.72E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci Gene:IST3(YIR005W)|FD-Score:3.34|P-value:4.13E-4||SGD DESC:Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing Gene:LDB7(YBL006C)|FD-Score:-3.85|P-value:5.85E-5||SGD DESC:Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions Gene:LEE1(YPL054W)|FD-Score:-3.36|P-value:3.89E-4||SGD DESC:Zinc-finger protein of unknown function Gene:LEO1(YOR123C)|FD-Score:3.12|P-value:8.99E-4||SGD DESC:Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:LPD1(YFL018C)|FD-Score:3.13|P-value:8.88E-4||SGD DESC:Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes Gene:MAL32(YBR299W)|FD-Score:3.11|P-value:9.37E-4||SGD DESC:Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose Gene:MET32(YDR253C)|FD-Score:3.3|P-value:4.90E-4||SGD DESC:Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication Gene:MRPS17(YMR188C)|FD-Score:3.38|P-value:3.58E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSK1(YNL073W)|FD-Score:3.88|P-value:5.20E-5||SGD DESC:Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys) Gene:PFK26(YIL107C)|FD-Score:4.1|P-value:2.08E-5||SGD DESC:6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A Gene:RKM3(YBR030W)|FD-Score:3.81|P-value:7.01E-5||SGD DESC:Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein Gene:RPL12B(YDR418W)|FD-Score:-3.21|P-value:6.67E-4||SGD DESC:Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication Gene:RPL22A(YLR061W)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication Gene:SAP4(YGL229C)|FD-Score:4.05|P-value:2.53E-5||SGD DESC:Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p Gene:SED1(YDR077W)|FD-Score:-3.09|P-value:9.88E-4||SGD DESC:Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites Gene:SIW14(YNL032W)|FD-Score:3.46|P-value:2.71E-4||SGD DESC:Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm Gene:SNF2(YOR290C)|FD-Score:3.79|P-value:7.52E-5||SGD DESC:Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p Gene:SRO77(YBL106C)|FD-Score:3.15|P-value:8.18E-4||SGD DESC:Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication Gene:TMA46(YOR091W)|FD-Score:3.25|P-value:5.68E-4||SGD DESC:Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p Gene:VAB2(YEL005C)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter Gene:YCR095W-A(YCR095W-A_p)|FD-Score:3.85|P-value:5.98E-5||SGD DESC:Putative protein of unknown function Gene:YDL057W(YDL057W_p)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Putative protein of unknown function; YDL057W is not an essential gene Gene:YDL177C(YDL177C_p)|FD-Score:3.38|P-value:3.63E-4||SGD DESC:Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene Gene:YDR535C(YDR535C_d)|FD-Score:4.3|P-value:8.68E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Gene:YGR111W(YGR111W_p)|FD-Score:3.12|P-value:9.17E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:YGR121W-A(YGR121W-A_p)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Putative protein of unknown function Gene:YKL162C(YKL162C_p)|FD-Score:-4.4|P-value:5.52E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:YLR184W(YLR184W_d)|FD-Score:3.26|P-value:5.62E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR087W(YMR087W)|FD-Score:3.65|P-value:1.30E-4||SGD DESC:Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain Gene:YPL062W(YPL062W_d)|FD-Score:4.1|P-value:2.07E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation Gene:YPQ1(YOL092W_p)|FD-Score:4.46|P-value:4.12E-6||SGD DESC:Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter Gene:YPR039W(YPR039W_d)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Gene:YPR126C(YPR126C_d)|FD-Score:3.24|P-value:5.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:ARK1(YNL020C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication Gene:ATG15(YCR068W)|FD-Score:3.14|P-value:8.41E-4||SGD DESC:Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Gene:BNA3(YJL060W)|FD-Score:3.14|P-value:8.52E-4||SGD DESC:Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate Gene:BSC6(YOL137W)|FD-Score:3.16|P-value:7.91E-4||SGD DESC:Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression Gene:CBR1(YIL043C)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia Gene:CEM1(YER061C)|FD-Score:3.42|P-value:3.08E-4||SGD DESC:Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Gene:CIT1(YNR001C)|FD-Score:5.71|P-value:5.52E-9||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication Gene:CST26(YBR042C)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication Gene:CTI6(YPL181W)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain Gene:DUG3(YNL191W)|FD-Score:4.6|P-value:2.09E-6||SGD DESC:Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) Gene:EAF1(YDR359C)|FD-Score:3.91|P-value:4.62E-5||SGD DESC:Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 Gene:ECM33(YBR078W)|FD-Score:-3.72|P-value:9.98E-5||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:ERV14(YGL054C)|FD-Score:4.11|P-value:2.02E-5||SGD DESC:COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication Gene:FMP10(YER182W_p)|FD-Score:3.76|P-value:8.48E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FYV7(YLR068W)|FD-Score:3.23|P-value:6.30E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin Gene:GAD1(YMR250W)|FD-Score:3.18|P-value:7.29E-4||SGD DESC:Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress Gene:GLC8(YMR311C)|FD-Score:3.89|P-value:5.06E-5||SGD DESC:Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress Gene:HUT1(YPL244C)|FD-Score:3.92|P-value:4.34E-5||SGD DESC:Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 Gene:IRC16(YPR038W_d)|FD-Score:-3.1|P-value:9.72E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci Gene:IST3(YIR005W)|FD-Score:3.34|P-value:4.13E-4||SGD DESC:Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing Gene:LDB7(YBL006C)|FD-Score:-3.85|P-value:5.85E-5||SGD DESC:Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions Gene:LEE1(YPL054W)|FD-Score:-3.36|P-value:3.89E-4||SGD DESC:Zinc-finger protein of unknown function Gene:LEO1(YOR123C)|FD-Score:3.12|P-value:8.99E-4||SGD DESC:Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:LPD1(YFL018C)|FD-Score:3.13|P-value:8.88E-4||SGD DESC:Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes Gene:MAL32(YBR299W)|FD-Score:3.11|P-value:9.37E-4||SGD DESC:Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose Gene:MET32(YDR253C)|FD-Score:3.3|P-value:4.90E-4||SGD DESC:Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication Gene:MRPS17(YMR188C)|FD-Score:3.38|P-value:3.58E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSK1(YNL073W)|FD-Score:3.88|P-value:5.20E-5||SGD DESC:Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys) Gene:PFK26(YIL107C)|FD-Score:4.1|P-value:2.08E-5||SGD DESC:6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A Gene:RKM3(YBR030W)|FD-Score:3.81|P-value:7.01E-5||SGD DESC:Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein Gene:RPL12B(YDR418W)|FD-Score:-3.21|P-value:6.67E-4||SGD DESC:Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication Gene:RPL22A(YLR061W)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication Gene:SAP4(YGL229C)|FD-Score:4.05|P-value:2.53E-5||SGD DESC:Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p Gene:SED1(YDR077W)|FD-Score:-3.09|P-value:9.88E-4||SGD DESC:Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites Gene:SIW14(YNL032W)|FD-Score:3.46|P-value:2.71E-4||SGD DESC:Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm Gene:SNF2(YOR290C)|FD-Score:3.79|P-value:7.52E-5||SGD DESC:Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p Gene:SRO77(YBL106C)|FD-Score:3.15|P-value:8.18E-4||SGD DESC:Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication Gene:TMA46(YOR091W)|FD-Score:3.25|P-value:5.68E-4||SGD DESC:Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p Gene:VAB2(YEL005C)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter Gene:YCR095W-A(YCR095W-A_p)|FD-Score:3.85|P-value:5.98E-5||SGD DESC:Putative protein of unknown function Gene:YDL057W(YDL057W_p)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Putative protein of unknown function; YDL057W is not an essential gene Gene:YDL177C(YDL177C_p)|FD-Score:3.38|P-value:3.63E-4||SGD DESC:Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene Gene:YDR535C(YDR535C_d)|FD-Score:4.3|P-value:8.68E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Gene:YGR111W(YGR111W_p)|FD-Score:3.12|P-value:9.17E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:YGR121W-A(YGR121W-A_p)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Putative protein of unknown function Gene:YKL162C(YKL162C_p)|FD-Score:-4.4|P-value:5.52E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:YLR184W(YLR184W_d)|FD-Score:3.26|P-value:5.62E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR087W(YMR087W)|FD-Score:3.65|P-value:1.30E-4||SGD DESC:Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain Gene:YPL062W(YPL062W_d)|FD-Score:4.1|P-value:2.07E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation Gene:YPQ1(YOL092W_p)|FD-Score:4.46|P-value:4.12E-6||SGD DESC:Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter Gene:YPR039W(YPR039W_d)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Gene:YPR126C(YPR126C_d)|FD-Score:3.24|P-value:5.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YJL090C4.231.18E-50.33DPB11DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress
YDR473C4.003.11E-50.33PRP3Splicing factor, component of the U4/U6-U5 snRNP complex
YOR340C3.993.24E-50.33RPA43RNA polymerase I subunit A43
YIL075C3.768.34E-50.33RPN2Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress
YDR062W3.432.99E-40.00LCB2Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YNL308C3.433.01E-40.07KRI1Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p
YPR180W3.363.93E-40.04AOS1Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YAL033W3.324.48E-40.05POP5Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YDR510W3.275.30E-40.11SMT3Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
YGR009C3.177.75E-40.04SEC9t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
YLR163C3.128.93E-40.02MAS1Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YHR036W3.119.50E-40.12BRL1Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
YJL008C2.980.001440.02CCT8Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YDR527W2.960.001530.02RBA50Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
YLR147C2.940.001630.10SMD3Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNR001C5.715.52E-9CIT1Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
YNL191W4.602.09E-6DUG3Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YOL092W_p4.464.12E-6YPQ1_pPutative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter
YDR535C_d4.308.68E-6YDR535C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YGL054C4.112.02E-5ERV14COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication
YPL062W_d4.102.07E-5YPL062W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YIL107C4.102.08E-5PFK266-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
YGL229C4.052.53E-5SAP4Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
YPL244C3.924.34E-5HUT1Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
YDR359C3.914.62E-5EAF1Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1
YMR311C3.895.06E-5GLC8Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress
YNL073W3.885.20E-5MSK1Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)
YCR095W-A_p3.855.98E-5YCR095W-A_pPutative protein of unknown function
YBR030W3.817.01E-5RKM3Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein
YOR290C3.797.52E-5SNF2Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p

GO enrichment analysis for SGTC_2646
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0741.15E-8SGTC_2731amoxapine 43.4 μMMiscellaneous21700.0253165
0.0732.32E-8SGTC_1309pyrazolanthrone 13.4 μMChemDiv (Drug-like library)85150.0149254
0.0715.94E-8SGTC_8660495-0101 262.0 μMChemDiv (Drug-like library)6356940.063291160S ribosome export
0.0622.07E-6SGTC_9953931-2021 34.6 μMChemDiv (Drug-like library)7301430.0886076RPP1 & pyrimidine depletion
0.0612.83E-6SGTC_9923909-8734 162.0 μMChemDiv (Drug-like library)42883190.0416667
0.0561.61E-5SGTC_20204017018 200.0 μMChembridge (Fragment library)211274910.0483871
0.0552.42E-5SGTC_1624st003710 6.2 μMTimTec (Natural product derivative library)242070330.0515464calcium & mitochondrial duress
0.0552.60E-5SGTC_22887946289 167.3 μMChembridge (Fragment library)12460520.0675676
0.0552.71E-5SGTC_282k297-0036 65.7 μMChemDiv (Drug-like library)50613780.025641
0.0543.12E-5SGTC_11871391-0724 117.0 μMChemDiv (Drug-like library)69979860.0229885amide catabolism
0.0543.49E-5SGTC_2670beta-carotene 100.0 μMMicrosource (Natural product library)52804890.780488
0.0535.26E-5SGTC_13581509-0022 2.5 μMChemDiv (Drug-like library)32584340.0138889
0.0525.99E-5SGTC_6501328-0195 38.0 μMChemDiv (Drug-like library)27808210.0144928
0.0518.49E-5SGTC_13732887-0003 58.5 μMChemDiv (Drug-like library)7769480.0641026Golgi
0.0501.16E-4SGTC_7313966-0296 387.0 μMChemDiv (Drug-like library)6609560.0506329

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2670beta-carotene100 μM0.7804885280489Microsource (Natural product library)536.8726411.99800
SGTC_1117retinoic acid1.11 μM0.6875444795TimTec (Natural product library)300.435125.55112
SGTC_2624nerol100 μM0.2637566Microsource (Natural product library)154.249322.93411
SGTC_1588farnesol29.9 μM0.196078445070TimTec (Pure natural product library)222.366344.7611
SGTC_2606farnesol9.78 μM0.196078445070Microsource (Natural product library)222.366344.7611
SGTC_2629bisabolol100 μM0.1692316097621Microsource (Natural product library)222.366344.30911
SGTC_2625euphol100 μM0.1645576708538Microsource (Natural product library)426.71748.11911
SGTC_2539epi(13)torulosol80 μM0.1643846708597Microsource (Natural product library)306.482764.19922
SGTC_6564090-1979187 μM0.15853722330961ChemDiv (Drug-like library)393.607926.6102
SGTC_404fumagillin50 μM0.15476212015870Miscellaneous458.543963.42117
SGTC_2519cryptotanshinone88.04 μM0.152778160254Microsource (Natural product library)296.36033.76103heme biosynthesis & mitochondrial translocase