Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YGL116W | 3.89 | 4.99E-5 | 0.50 | CDC20 | Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress |
YOL038W | 3.39 | 3.51E-4 | 0.07 | PRE6 | Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress |
YNR035C | 3.32 | 4.47E-4 | 0.19 | ARC35 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin |
YML077W | 3.13 | 8.74E-4 | 0.01 | BET5 | Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi |
YNL216W | 3.12 | 9.06E-4 | 0.06 | RAP1 | Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain) |
YLR029C | 3.06 | 0.00112 | 0.03 | RPL15A | Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication |
YBR135W | 3.02 | 0.00126 | 0.09 | CKS1 | Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters |
YLL008W | 2.93 | 0.00171 | 0.09 | DRS1 | Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles |
YDR308C | 2.84 | 0.00227 | 0.15 | SRB7 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p |
YMR314W | 2.69 | 0.00356 | 8.57E-4 | PRE5 | Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
YGR005C | 2.69 | 0.00357 | 0.03 | TFG2 | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30 |
YER012W | 2.66 | 0.00391 | 0.09 | PRE1 | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle |
YDR228C | 2.57 | 0.00513 | 0.15 | PCF11 | mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping |
YPL094C | 2.42 | 0.00782 | 0.08 | SEC62 | Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER |
YLR008C | 2.34 | 0.00967 | 0.07 | PAM18 | Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p |